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Method for preparing external paste for treating arthralgia

A joint pain and plaster technology, which is applied in the field of preparation of external plasters, can solve the problems of low volatility of active ingredients, long-lasting effects of medicines, poor efficacy of medicines, and volatilization of active ingredients in plasters, etc., to achieve good swelling and emulsification effects, and volatile Low toxicity, good long-lasting effect

Active Publication Date: 2017-12-01
杭州仁德药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems that the existing plaster preparation methods lead to the volatilization of the active ingredients of the plaster and poor drug effect persistence, the object of the present invention is to provide a preparation method of an external plaster for treating arthralgia, and the plaster for treating arthralgia prepared by this method Rosin active ingredients in external plasters have low volatility, good long-lasting effect, and the ingredients are evenly dispersed, resulting in uniform plaster quality

Method used

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  • Method for preparing external paste for treating arthralgia
  • Method for preparing external paste for treating arthralgia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method for an external plaster for treating arthralgia, comprising the following steps:

[0031] (1) Rubber rolling: the raw rubber is removed from the film and cut into 10cm long rubber strips, put into a rubber mixing machine and rolled to obtain a rubber sheet, so that both sides of the rubber sheet form a grid pattern, and the thickness of the rubber sheet is 3mm;

[0032](2) Swelling rubber: place the rubber flakes in a mixer and add gasoline solvent, stir regularly and soak in ultrasonic for later use, wherein the gasoline solvent used is mixed with No. 120 gasoline and ethanol, and the volume percentage of No. 120 gasoline is 80%. The weight ratio of rubber flakes to gasoline solvent is 1:4.2, the stirring and soaking process is: stir for 2 minutes every 3 hours, and then continue to soak for more than 24 hours until the rubber flakes are fully swollen and softened, preferably 25 hours, and the stirring speed is 30r / min , the soaking temperature is ...

Embodiment 2

[0041] A preparation method for an external plaster for treating arthralgia, comprising the following steps:

[0042] (1) Rubber rolling: the raw rubber is removed from the film and cut into 15cm long rubber strips, put into a rubber mixing machine and rolled to obtain a rubber sheet, so that both sides of the rubber sheet form a grid pattern, and the thickness of the rubber sheet is 4mm;

[0043] (2) Swelling rubber: the rubber sheet is placed in a mixer and added gasoline solvent, regularly stirred and ultrasonically soaked for later use, wherein the gasoline solvent used is mixed with No. 120 gasoline and ethanol, and the volume percentage of No. 120 gasoline is 85%. The weight ratio of rubber flakes to gasoline solvent is 1:5.5. The stirring and soaking process is: stir for 2 minutes every 3 hours, and then continue to soak for more than 24 hours until the rubber flakes are fully swollen and softened, preferably 27 hours, and the stirring speed is 35r / min , the soaking tem...

Embodiment 3

[0052] A preparation method for an external plaster for treating arthralgia, comprising the following steps:

[0053] (1) Rubber rolling: the raw rubber is removed from the film and cut into 10cm long rubber strips, put into a rubber mixing machine and rolled to obtain a rubber sheet, so that both sides of the rubber sheet form a grid pattern, and the thickness of the rubber sheet is 5mm;

[0054] (2) Swelling rubber: place the rubber flakes in a mixer and add gasoline solvent, stir regularly and soak in ultrasonic for later use, wherein the gasoline solvent used is mixed with No. 120 gasoline and ethanol, and the volume percentage of No. 120 gasoline is 90%. The weight ratio of rubber flakes to gasoline solvent is 1:4.2. The stirring and soaking process is: stir for 2 minutes every 3 hours, and then continue to soak for more than 24 hours until the rubber flakes are fully swollen and softened. The stirring speed is 40r / min, and the soaking temperature is 30°C, ultrasonic assi...

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Abstract

The invention belongs to the technical field of ointment preparations, and in particular relates to a method for preparing an external paste for treating arthralgia. The method comprises the following steps: cutting rubber into strips, rolling into thin rubber sheets, swelling and emulsifying in a gasoline solvent, putting raw materials into the gasoline solvent with the thin rubber sheets, uniformly stirring, filtering so as to obtain rubber slurry, coating a back lining with the slurry so as to obtain an ointment paste, and performing scrolling, lining covering and packaging. The external paste for treating arthralgia, which is prepared by using the method, has the advantages that the paste is good in function of inflammation diminishing and pain relieving, low in volatilization and long in medicinal effect lasting, the rubber is good in swelling emulsion effect, low in gasoline residue and not liable in solvent exosmosis, the paste lining is good in packaging effect and not easy to moisten, materials are uniformly dissolved and dispersed, and the ointment is uniform in quality, good in antibacterial effect and inflammation diminishing effect and long in preservation period.

Description

technical field [0001] The invention belongs to the technical field of plaster preparations, and in particular relates to a preparation method of an external plaster for treating arthralgia. Background technique [0002] Plasters have a long history of application in our country. Vegetable or animal oils are added to make a jelly-like substance, which can be pasted on the affected area for a long time on one side of cloth, paper or leather. The medicine in the plaster is directly applied to the acupuncture points on the body surface. , the property of the medicine permeates the subcutaneous tissue from the surface to the inside through the fur. On the one hand, the relative advantage of the drug concentration is produced locally. So as to exert the greatest systemic pharmacological effect. Traditional injection and oral therapy damage nerves, blood vessels, muscles and other tissues, making it difficult for patients to accept, and these methods are easy to disperse the medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/15A61K9/70A61K47/69A61K47/38A61K47/36A61K47/44A61K47/02A61P19/02A61P29/00A61K31/045A61K31/125A61K31/405A61K31/4453
CPCA61K9/7046A61K9/7076A61K31/045A61K31/125A61K31/405A61K31/4453A61K36/15A61K47/02A61K2300/00
Inventor 俞帮和徐明蒋志刚汪海涛
Owner 杭州仁德药业股份有限公司
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