Nano-selenium hydrosol with anti-tumor activity, preparation, preservation method and application
A technology of nano-selenium and hydrosol, which is applied in the direction of anti-tumor drugs, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve the problems of not being able to effectively improve the biological activity of nano-selenium
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[0040] Correspondingly, on the basis of providing the nano-selenium hydrosol with anti-tumor activity, the present invention further provides a preparation method of the nano-selenium hydrosol with anti-tumor activity. In a specific embodiment, the preparation method of the nano-selenium hydrosol with anti-tumor activity at least includes the following steps:
[0041] Step S01. Adding a solution containing selenium ions and / or selenium ions to the polysaccharide protein aqueous solution of versicolor versicolor;
[0042] Step S02. Add a reducing agent solution dropwise to the mixed solution obtained in step S01, and oscillate;
[0043] Step S03. The product obtained from the reduction reaction in step S02 is subjected to constant volume and dialysis treatment.
[0044] In any embodiment, the versicolor polysaccharide protein in the versicolor polysaccharide protein aqueous solution is versicolor versicolor water-soluble polysaccharide protein.
[0045] As preferably, in the em...
Embodiment 1
[0064] (1) At 25°C and 101.325kPa, 0mL, 0.5mL, 1.0mL, 3.0mL, 6.0mL of Versicolor versicolor water-soluble polysaccharide protein with a mass concentration of 2.5g / L were added to 5 mL of double-distilled water containing 10.0mL respectively. In a 25mL volumetric flask;
[0065] (2) Add 1.0 mL of sodium selenite solution with a concentration of 0.025 mol / L to the above-mentioned 25 mL volumetric flask respectively, shake it up gently, and make it fully mixed to obtain a mixed solution;
[0066] (3) To the mixed solution in (2), add 1.0 mL of vitamin C solution with a concentration of 0.1 mol / L dropwise, shake gently while adding, add water to make up to 25.0 mL, and let stand , until the red color no longer deepens, and then dialyzed (molecular weight cut-off 8000) for 24 hours, the product can be obtained. The content of selenium was measured by nitration ICP method. It can be seen that the concentration of nano-selenium in the obtained product is basically about 1.0-1.5mmol / ...
Embodiment 2
[0080] (1) At 20°C and 101.325kPa, take 3.0mL of Versicolor versicolor water-soluble polysaccharide protein aqueous solution with a mass concentration of 2.5g / L and add them to four 25mL volumetric flasks filled with 10mL of double-distilled water;
[0081] (2) Add 0.1mL, 0.5mL, 1.0mL, 2.0mL of sodium selenite solutions with a concentration of 0.025mol / L to the above-mentioned 25mL volumetric flask, shake gently, and make it fully mixed to obtain a mixed solution;
[0082] (3) Add dropwise 0.1mL, 0.5mL, 1.0mL, 2.0mL of vitamin C (English abbreviation: Vc) solutions with a concentration of 0.1mol / L to the mixed solution in (2), shake gently while adding After the addition is complete, add water to make up to 25mL, let it stand still until the red color no longer deepens, and then dialyze (molecular weight cut-off 8000) for 24 hours to obtain the product. The selenium content is measured by the nitration ICP method, and it can be known that the nano-selenium concentration in the o...
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