3D (Three dimensional) printed hydrochlorothiazide tablets and preparation method thereof

A technology for selling hydrochlorothiazide tablets and chlorothiazide tablets, which is applied in the field of 3D printing hydrochlorothiazide tablets and its preparation, can solve the problems of microbial contamination, inaccurate dosage, hyponatremia, etc., and achieve accurate volume, beautiful appearance, and drug combination. with safe effect

Active Publication Date: 2017-12-01
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And studies have shown that most of the adverse reactions of hydrochlorothiazide tablets are related to the dose and course of treatment, which can cause hypokalemia, hyponatremia, hyperglycemia, hyperuricemia, etc.
[0004] At present, the traditional method of hydrochloroth...

Method used

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  • 3D (Three dimensional) printed hydrochlorothiazide tablets and preparation method thereof
  • 3D (Three dimensional) printed hydrochlorothiazide tablets and preparation method thereof
  • 3D (Three dimensional) printed hydrochlorothiazide tablets and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] (1) Preparation of printed drug powder

[0040] Take commercially available hydrochlorothiazide tablets, poloxamer 407, PEG4000, magnesium stearate, crush and grind, pass through a 120-mesh sieve, and accurately weigh according to the following mass ratio:

[0041]

[0042] Put PEG4000 and poloxamer 407 in an evaporating dish, heat and stir in a water bath at 58°C to melt. Add commercially available hydrochlorothiazide tablet powder several times in small amounts, and stir with a glass rod until the drug and excipients are evenly mixed in the evaporating dish. Put the mixed molten printing material into the refrigerator, and store it at 4°C for 4 hours to solidify. Take out the printed material and pulverize it with a pulverizer, pass through an 80-mesh sieve, add 1 / 19 magnesium stearate and mix with it to obtain 3D printed hydrochlorothiazide tablet powder.

[0043] The density of the printed drug powder was measured to be ρ=1.41067g / mL.

[0044] The drug content...

Embodiment 2

[0058] (1) Preparation of printed drug powder

[0059] Take commercially available hydrochlorothiazide tablets, poloxamer 407, PEG4000 (i.e. polyethylene glycol 4000), magnesium stearate, crush and grind, pass through a 120-mesh sieve, and accurately weigh according to the following mass ratio:

[0060]

[0061] Put PEG4000 and poloxamer 407 in an evaporating dish, heat and stir in a water bath at 58°C to melt. Add commercially available hydrochlorothiazide tablet powder several times in small amounts, and stir with a glass rod until the drug and excipients are evenly mixed in the evaporating dish. Put the mixed molten printing material into the refrigerator, and store it at 4°C for 4 hours to solidify. Take out the printed material and pulverize it with a pulverizer, pass through an 80-mesh sieve, add 1 / 19 magnesium stearate and mix with it to obtain 3D printed hydrochlorothiazide tablet powder.

[0062] The density of the 3D printed hydrochlorothiazide tablet powder was...

Embodiment 3

[0078] (1) Preparation of printed drug powder

[0079] Take commercially available hydrochlorothiazide tablets, poloxamer 407, PEG4000, and magnesium stearate with a specification of 25 mg, crush and grind, pass through a 120-mesh sieve, and accurately weigh according to the following mass ratio:

[0080]

[0081] Put PEG4000 and poloxamer 407 in an evaporating dish, heat and stir in a water bath at 58°C to melt. Add commercially available hydrochlorothiazide tablet powder several times in small amounts, and stir with a glass rod until the drug and excipients are evenly mixed in the evaporating dish. Put the mixed molten printing material into the refrigerator, and store it at 4°C for 4 hours to solidify. Take out the printed material and pulverize it with a pulverizer, pass through an 80-mesh sieve, add 1 / 19 magnesium stearate and mix with it to obtain 3D printed hydrochlorothiazide tablet powder.

[0082] The density of the printed drug powder was measured to be ρ=1.410...

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Abstract

The invention provides 3D (three dimensional) printed hydrochlorothiazide tablets and a preparation method thereof. The preparation method comprises the following steps: performing accurate divided dose on commercially available hydrochlorothiazide tablets by using a 3D hot melt extrusion technology, firstly, preparing the commercially available hydrochlorothiazide tablets and auxiliary materials into 3D printed hydrochlorothiazide tablet powder, then generating the tablet models with different sizes through the modeling software to determine the dose contained in the tablets, and finally setting the corresponding parameters in a 3D printer to print and prepare the 3D printed hydrochlorothiazide tablets. The 3D printed hydrochlorothiazide tablets prepared by the invention can precisely perform divided dose on the commercially available hydrochlorothiazide tablets to enable the hydrochlorothiazide tablets to be safer in combination with drugs for the treatment of hypertension; aesthetic appearance and integrity are realized, and patient compliance and easier preservation and transportation are improved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a 3D printed hydrochlorothiazide tablet and a preparation method thereof. Background technique [0002] As a manufacturing technology, 3D printing has developed rapidly in many fields of science and technology. Due to its advantages such as simple operation, good flexibility, high repeatability, and wide adaptability, it has attracted the attention of drug formulation developers. In-depth research and wide application in high-end pharmaceutical preparations such as release preparations, implants and compound preparations. Since the process can be designed and controlled by computer, the production batch and production scale have less influence on the final product, making it more personalized. In recent years, 3D printing technology has been increasingly used in the field of pharmacy to prepare special solid dosage forms containing active drugs. With the hel...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/549A61K47/10A61K47/12A61P9/12B33Y80/00B33Y10/00B33Y50/02
CPCA61K9/2031A61K9/2095A61K31/549B33Y10/00B33Y50/02B33Y80/00
Inventor 杨帆陈燕忠
Owner GUANGDONG PHARMA UNIV
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