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Compositions and methods to prevent and repair acute kidney injury

A composition, a technique for renal injury, a statement of application under investigation
[0006] The U.S. government under the following grants in the present invention, ischemia/reperfusion, AKI, can solve the problems of high cost, long-term hospitalization, etc.

Active Publication Date: 2017-11-28
RUTGERS THE STATE UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, patients suffering from AKI in this setting require long-term hospitalization, resulting in high costs for AKI treatment and chronic renal failure prevention

Method used

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  • Compositions and methods to prevent and repair acute kidney injury
  • Compositions and methods to prevent and repair acute kidney injury
  • Compositions and methods to prevent and repair acute kidney injury

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Embodiment

[0173] Discovery of MG53, a muscle-specific TRIM family protein . MG53 was isolated using a previously established immunoproteomics approach that allowed the identification of genes involved in myogenesis, Ca 2+ Novel proteins for signaling and maintenance of membrane integrity in striated muscle cells. Briefly, the method uses a monoclonal antibody library containing ~6500 clones generated by immunizing mice with triplet-enriched membranes from rabbit skeletal muscle. Antibodies of interest were selected based on the z-line staining pattern of striated muscle sections observed under immunofluorescence microscopy. Purify the target protein through an antibody affinity column to obtain a partial amino acid sequence of the purified protein. Based on the partial amino acid sequence, the complete cDNA encoding the target gene was isolated from the skeletal muscle cDNA library. Homologous gene screens were then used to search for the presence of different isoforms of the ident...

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Abstract

Disclosed herein are compositions and methods for repairing cell membranes. In particular, the description provides compositions and methods comprising MG53, a member of the TRIM-family of proteins, in the repair of kidney injury and its therapeutic use in the prevention and treatment of kidney injury.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 098,154, filed December 30, 2014, and entitled Compositions and Methods to Prevent and Repair Acute Kidney Injury, which is incorporated herein by reference . [0003] incorporated by reference [0004] According to 37 C.F.R. §1.52(e)(5), the sequence information contained in the electronic file name: Ma_2015utility_ST25.txt; size 57KB; creation date: December 29, 2015; used Patent-In 3.5 and Checker4.4.0 The entire content of is hereby incorporated by reference herein. [0005] Statement Regarding Federally Sponsored Research [0006] The United States Government has certain rights in this invention under grant: RO1-HL0691000 awarded by the National Institutes of Health (NIH) to Dr. Jianjie Ma. Background technique [0007] 1. The field of discovery. The present invention relates to polypeptide compositions and methods of the...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P13/12
CPCA61K38/1703A61K38/16A61K38/17A61K39/395C07K16/18A61P13/12
Inventor P·杜安谭涛麻建杰
Owner RUTGERS THE STATE UNIV
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