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Anti-infection medical wound dressing and preparation method thereof

An anti-infection and wound-surface technology, applied in the field of medical materials, can solve the problems of anti-infection, bacteriostatic, no scarring, promoting healing effect and liquid absorption, etc., and achieve the effect of good healing effect, good antibacterial and anti-infection, and no scars.

Inactive Publication Date: 2017-11-28
苏州凌科特新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many studies on wound dressings, most hydrogel dressings have more or less defects and deficiencies in terms of anti-infection and antibacterial properties, no scarring, healing-promoting effect, and liquid absorption. limit its scope of application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The anti-infection medical wound dressing is prepared from the following raw materials in parts by weight: 5 parts of bacterial cellulose, 0.5 part of polyaspartic hydrazide, 0.1 part of polyvinyl alcohol, 0.3 part of sodium polyacrylate, 2 parts of tragacanth gum, urine 0.6 parts of cystin, 0.4 parts of galacturonic acid, 0.03 parts of menahydroquinone acetate, 0.1 parts of kaempferol glucuronide, 1.2 parts of plant water extract, 2.4 parts of polyoxyethylene polyoxypropylene ether block copolymer, 0.5 parts of polyethylene glycol diglycidyl ether, 15 parts of glycerin, and 26 parts of distilled water.

[0023] The preparation steps of the bacterial cellulose are as follows: adding the bacteria into the seed medium, culturing at 20°C for 10 hours, inoculating it into the fermentation medium, culturing at 20°C for 10 hours, and decanting to obtain the bacterial cellulose; Wherein, the bacterial species is Glucobacterium; the seed culture medium comprises 2.5% by weight ...

Embodiment 2

[0032]The anti-infection medical wound dressing is prepared from the following raw materials in parts by weight: 15 parts of bacterial cellulose, 3 parts of polyaspartic hydrazide, 1.4 parts of polyvinyl alcohol, 1 part of sodium polyacrylate, 6 parts of tragacanth gum, urine 2.5 parts of cystin, 1.8 parts of galacturonic acid, 0.15 parts of menahydroquinone acetate, 0.28 parts of kaempferol glucuronide, 3.2 parts of plant water extract, 7.3 parts of polyoxyethylene polyoxypropylene ether block copolymer, 4 parts of polyethylene glycol diglycidyl ether, 28 parts of glycerin, 40 parts of distilled water.

[0033] The preparation steps of the bacterial cellulose are as follows: adding the bacteria into the seed medium, culturing at 30°C for 24 hours, inoculating it into the fermentation medium, culturing at 30°C for 24 hours, and decanting to obtain the bacterial cellulose; Wherein, the strain is Pseudomonas cepacia; the seed culture medium comprises 2.5% by weight of glucose, 1...

Embodiment 3

[0042] The anti-infection medical wound dressing is prepared from the following raw materials in parts by weight: 5.7 parts of bacterial cellulose, 0.8 parts of polyaspartic hydrazide, 0.4 parts of polyvinyl alcohol, 0.4 parts of sodium polyacrylate, 2.5 parts of tragacanth gum, urine 0.8 parts of cystin, 0.7 parts of galacturonic acid, 0.05 parts of menahydroquinone acetate, 0.14 parts of kaempferol glucuronide, 1.3 parts of plant water extract, 2.8 parts of polyoxyethylene polyoxypropylene ether block copolymer, 0.6 parts of polyethylene glycol diglycidyl ether, 18 parts of glycerin, and 30 parts of distilled water.

[0043] The preparation steps of the bacterial cellulose are as follows: adding the bacteria into the seed medium, culturing at 25°C for 18 hours, inoculating it into the fermentation medium, culturing at 25°C for 24 hours, decanting, and obtaining the bacterial cellulose; Wherein, the strain is Bacillus aceti; the seed culture medium comprises 2.5% by weight of...

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Abstract

The invention provides an anti-infection medical wound dressing and a preparation method thereof. The anti-infection medical wound dressing is prepared from the following raw materials: bacterial cellulose, polyasparthydrazide, polyvinyl alcohol, sodium polyacrylate, tragacanth, allantoin, galacturonic acid, menadiol diacetate, kaempferol-3-beta-O-glucuronide, a plant water extract, a polyoxyethylene polyoxypropylene ether block copolymer, diethylene glycol diglycidyl ether, glycerin and distilled water. The prepared medical wound dressing has good anti-microbial and anti-infection performance as well as broad-spectrum antibacterial property; a healing period with application of the dressing is controlled within one week, the healing promoting effect is obvious, regenerated skin after healing is smooth and fine on surface, scar is avoided, the wound healing capacity is excellent, the healing effect is good, and the dressing is applicable to treatment of various wounds such as trauma, burn, ulcer and the like.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an anti-infection medical wound dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body. It wraps the entire surface of the human body and connects with the mucosal epithelium of the outer openings of the digestive, respiratory, urinary, and reproductive systems, thus forming the most ideal coat of the human body to protect the internal organs and prevent the invasion of various external factors. . Cuts, scratches, bruises, bruises, squeezes, abrasions, lacerations, punctures, mosquito bites, burns and other traumas due to biting, squeezing, friction, falling, surgery, etc. These wounds must be treated in time, otherwise suppurative infection will occur due to the invasion of pathogenic bacteria, and local redness, swelling, heat, pain and dysfunction will also occur. In severe cases, bacteria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/40A61L15/28
CPCA61L15/28A61L15/40A61L15/46A61L2300/232A61L2300/30A61L2300/404C08L1/02
Inventor 李子寅
Owner 苏州凌科特新材料有限公司
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