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Application of antagonist of il-36r in preparation of analgesic medicine

A drug and pain-sensing technology, applied in the field of biomedicine, to achieve rapid onset, significant relief, and large relief

Active Publication Date: 2020-11-10
SHANGHAI CHILDRENS HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there has been no report on the use of IL-36R antagonists in analgesia

Method used

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  • Application of antagonist of il-36r in preparation of analgesic medicine
  • Application of antagonist of il-36r in preparation of analgesic medicine
  • Application of antagonist of il-36r in preparation of analgesic medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Experimental materials: IL-36R antagonist IL-36Ra was purchased from R&D Company (Recombinant Mouse IL-36Ra / IL-1F5 Protein, 2714-ML-025 / CF).

[0035] 2. Experimental animals: SPF grade BALB / C mice, male, 8 weeks old, 16-20g (Slack Experimental Animal Center). random grouping.

[0036] 3. Experimental method:

[0037] 1. Make a model

[0038]1) Mouse plantar injection of CFA inflammatory pain model (CFA model): the right lower limb of the mouse was fixed, and 30 μl of CFA was injected into the middle of the plantar with a micro-syringe, and the same volume of normal saline was injected into the plantar of the control group.

[0039] 2) Mouse sciatic nerve chronic compressive injury neuralgia model (CCI model): After mice were anesthetized by intraperitoneal injection of pentobarbital sodium, the skin was cut on the upper edge of the mouse's right hind limb, and the muscles were separated longitudinally to expose the trunk of the sciatic nerve. The sciatic nerve is ...

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Abstract

The invention relates to an application of an IL-36R antagonist in preparing a pain-relieving drug. The invention finds that an intrathecally taken IL-36R antagonist is capable of relieving the painful behavior responses, including mechanical allodynia and thermal hyperalgesia, of rat to inflammatory pain and neuralgia, is capable of quickly becoming effective and greatly relieving and is long in lasting time, so that the IL-36R antagonist can be used as an effective composition of the drug, can be further prepared into the pain-relieving drug and can be used for clinically treating pain, especially treating inflammatory pain and neuralgia.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of an IL-36R antagonist in the preparation of analgesic drugs. Background technique [0002] The so-called pain in modern medicine is a complex physiological and psychological activity, which includes the pain sensation caused by noxious stimuli acting on the body, and the body's pain response to noxious stimuli (body motor response and / or visceral response). Vegetative reactions, often accompanied by strong emotional overtones). [0003] Pain can be divided into acute pain and chronic pain based on the duration of the pain and the possible healing time of the damaged tissue. A relatively general definition of acute pain is: a type of pain associated with tissue injury, inflammation, or disease process that is of short duration (usually less than 3 months). Such as the sting of a bee, the sting of a knife, the pain of childbirth, etc. Corresponding to acute...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P29/00A61P25/02
CPCA61K38/1793
Inventor 李倩李玲玲周君梅
Owner SHANGHAI CHILDRENS HOSPITAL
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