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Blood fat reducing trichosanthes peel compound and preparing method thereof

A technology of trichosanthes peel and blood lipid lowering, which is applied in the direction of medical formulas, medical preparations containing active ingredients, food ingredients as antioxidants, etc., can solve the problems of difficult maintenance of curative effect, easy rebound, liver function damage, etc., and achieve significant Antioxidant activity, good regulation of blood lipids, and improvement of blood lipid metabolism

Inactive Publication Date: 2017-11-17
YANCHENG TEACHERS UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine is effective in lowering lipids, but clinical observations show that it is easy to rebound after use, the curative effect is not easy to maintain, and there are side effects such as damage to liver function, so people are somewhat afraid of it

Method used

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  • Blood fat reducing trichosanthes peel compound and preparing method thereof
  • Blood fat reducing trichosanthes peel compound and preparing method thereof
  • Blood fat reducing trichosanthes peel compound and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1. The preparation of compound

[0022] Take the extract of Trichosanthes rind and the extract of Allium scallops respectively, mix them according to the different mass ratios listed in Table 1 (Pipes of Trichosanthes scallops: Extract of Allium scallops), add a certain volume of pure water, mix evenly, and configure the concentration to be 2.1g / mL (crude drug volume), prepared into a medicinal compound composition for subsequent use.

[0023] Table 1 compound composition

[0024]

Embodiment 2

[0025] Embodiment 2. Antioxidant and hypolipidemic activity experiment

[0026] experimental animals

[0027] C57BL / 6 mice, male, weighing about 20g, 3-5w weeks old, clean grade, provided by Shanghai Slack Experimental Animal Co., Ltd., were raised in the SPF animal room of the Animal Center of Yancheng Health Vocational and Technical College, certificate number: SCXK ( Shanghai 2012-0002)

[0028] mouse feed

[0029] The basic feed (the feed was prepared according to GB14924.3-2001 "Compound Feed for Experimental Animals, Mice and Rats"), and the high-fat feed was prepared according to the CFDA standard. In order to prevent the feed from being oxidized, fresh feed was prepared every week and stored in a -20°C refrigerator.

[0030] Experimental Materials and Instruments

[0031] Bezafibrate Tablets Jiangsu Tasly Beta Pharmaceutical Co., Ltd. (National Drug Accreditation: H20010013), superoxide dismutase (SOD) kit, malondialdehyde (MDA) kit, glutathione peroxidase ( GSH-P...

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Abstract

The invention discloses a blood fat reducing trichosanthes peel compound. The compound comprises trichosanthes peel extract and allium macrostemon extract which serve as effective components, and the ratio of trichosanthes peel to allium macrostemon raw material is 1:7.83-1:3.58. The trichosanthes peel extract and allium macrostemon extract and trichosanthes peel and allium macrostemon extract can improve blood fat metabolism of hyperlipidemic mice after compatibility, and the blood fat adjusting effect of the group of trichosanthes peel extract and allium macrostemon extract of different ratios is better than that of using the richosanthes peel extract or the allium macrostemon extract singly. It is indicated that the active components in richosanthes peel and allium macrostemon take the synergistic effect and can adjust blood fat better, and the compound has remarkable antioxidant activity and has the active repairing function on the liver.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a blood lipid-lowering compound mainly composed of Trichosanthes bark extract and Allium scallions extract. Background technique [0002] In modern society, with changes in lifestyle and environment, the spectrum of human diseases has changed greatly from the past. Cardiovascular diseases have become one of the main chronic diseases that endanger human health. Hyperlipidemia has exacerbated the increase in metabolic disorders. In addition to the risk of cardiovascular disease, hyperlipidemia and its complications are considered to be one of the important social problems. Hyperlipidemia is a lifelong disease of abnormal blood lipid metabolism. Through drug treatment, blood lipids can be stabilized between normal values, but has not been cured. If the drug treatment is stopped, the blood lipid concentration will increase again. Western medicine is effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61P3/06A61P39/06A61P1/16A23L33/105
CPCA23L33/105A23V2002/00A61K36/428A61K36/8962A61K2236/333A61K2236/39A61K2300/00A23V2250/21A23V2200/3262A23V2200/02
Inventor 王伯初杨丽季庆治侯宗坤
Owner YANCHENG TEACHERS UNIV
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