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Medicine for relieving glucose and lipid metabolism disorder and improving vascular function and preparing method for medicine

A technology for glucose and lipid metabolism and disorder, applied in the field of medicine, can solve problems such as large side effects and patient withdrawal treatment, and achieve the effects of less side effects, improved microcirculation, good symmetry and repeatability

Inactive Publication Date: 2017-11-17
成都医学院第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In summary, the problems in the prior art are: the prior art has the disadvantages of drug treatment for glucose and lipid metabolism disorders, that is, large side effects, and patients stop drug treatment because they cannot tolerate the side effects of the drugs.

Method used

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  • Medicine for relieving glucose and lipid metabolism disorder and improving vascular function and preparing method for medicine
  • Medicine for relieving glucose and lipid metabolism disorder and improving vascular function and preparing method for medicine
  • Medicine for relieving glucose and lipid metabolism disorder and improving vascular function and preparing method for medicine

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Effect test

preparation example Construction

[0034] Such as figure 1 As shown, the drug preparation method for improving glucose and lipid metabolism disorders and vascular function in the embodiments of the present invention includes the following steps:

[0035] S101: Take 100g of Danshen medicinal material crushed into fine powder, add 8 times the volume (V / W) of 60% ethanol, soak at 5°C for 24 hours, and then ultrasonically extract for 30 minutes. During the extraction process, use circulating water to cool the extract to control the temperature of the extract not exceeding Centrifuge at 20°C, recover ethanol from the extract until it has no alcohol smell.

[0036] S102: Adsorption and separation of macroporous resin: the clarified alcohol-free extract is placed on a D-101 macroporous resin column, and the ratio of the loaded sample (calculated based on the dry weight of the original medicinal material) to the amount of the resin is 1:2 (W / V). Impurities were first eluted with 2 column volumes of water, and then 5 c...

Embodiment 1

[0047] Salvianolic acid B (100mg / kg / day) can significantly reduce the body weight of db / db mice ( figure 2 Middle A) and fasting blood glucose level ( figure 2 Middle B panel), compared with db / db control mice, all P0.05 or P0.05; Results See figure 2 Middle C figure.

Embodiment 2

[0049] Compared with the wild-type control C57BL / KsJ, the NO level in the aortic intima of db / db mice was significantly decreased, and the superoxide anion level was significantly increased, all P<0.01; salvianolic acid B intervention can significantly reduce the superoxide anion level, increase the Intimal NO level, all P<0.01.

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Abstract

The invention belongs to the technical field of medicine and pharmacology, and discloses a medicine for relieving glucose and lipid metabolism disorder and improving the vascular function and a preparing method for the medicine. The medicine for relieving glucose and lipid metabolism disorder and improving the vascular function is salvianolic acid B. The molecular formula of salvianolic acid B is C36H30O16. The preparing method for the medicine for relieving glucose and lipid metabolism disorder and improving the vascular function comprises the following steps that radix salviae miltiorrhizae medicinal materials are smashed into fine powder and are sieved through a 20-60-mesh sieve; an ethanol solution is added into the fine powder, the fine powder is soaked under the temperature less than 5 DEG C, ultrasonic extracting is conducted, and the extraction process temperature is lower than 25 DEG C; centrifuging is conducted on extracted liquid, filtering is conducted, ethanol is recovered after pressure reducing till the extracted liquid has no alcohol smell, and the extracted liquid is concentrated and filtered; and the extracted liquid is clarified, enrichment is conducted through macroporous resin first, then chromatographic column chromatography purifying is conducted, freezing and drying are conducted, and a salvianolic acid B extract substance is obtained. The medicine for relieving glucose and lipid metabolism disorder and improving the vascular function has the good protective effect on myocardial infarction and also can obviously relieving injuring of myocardial ischemia / reperfusion; thrombus is prevented from forming by anti-platelet aggregation; microcirculation is improved; and anti-oxidation injury is avoided.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for improving glucose and lipid metabolism disorder and blood vessel function and a preparation method thereof. Background technique [0002] Diabetes and obesity are major diseases that affect the health of Chinese people. At present, there are more than 114 million diabetic patients and more than 70 million obese patients in China. Obesity is closely related to cardiovascular disease and diabetes, and glucose and lipid metabolism disorders play a vital role in the occurrence and development of atherosclerosis. OASIS study, Italian acute myocardial infarction study (GISSI-2, GISSI-3), SHOCK study, etc. all confirmed that the proportion of myocardial infarction in diabetic patients is increasing year by year. The OASIS study showed that diabetes increased the mortality rate of patients with unstable angina and non-Q wave myocardial infarction by 57%. The...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61P3/10A61P9/10A61K36/537
Inventor 王沛坚万进东侯霁芯王丹刘家欣阚竞宇刘森周鹏
Owner 成都医学院第一附属医院
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