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A preparing method of a cosmetic medical microneedle paster

A production method and technology of microneedle sticking, applied in the direction of microneedles, needles, medical devices, etc., can solve the problems of increasing process complexity, production cost, and increasing process difficulty, so as to improve mass production efficiency and save process time Effect

Active Publication Date: 2017-11-14
WIN COAT CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the above-mentioned process method must additionally consider the spacing and alignment between the multiple protruding support shafts on the support substrate and the multiple carriers, which increases the difficulty of the process; and additionally, the adhesive needs to be pre-coated during the production process. Only a few steps are required to bond the support substrate and the carrier, all of which increase the complexity of the process and the production cost

Method used

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  • A preparing method of a cosmetic medical microneedle paster
  • A preparing method of a cosmetic medical microneedle paster
  • A preparing method of a cosmetic medical microneedle paster

Examples

Experimental program
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Effect test

Embodiment 1

[0068] Please refer to figure 1 and figure 2 As shown, the medical aesthetic microneedle patch of this embodiment is prepared by the following method.

[0069] First, if figure 1 and figure 2 In the step (a) shown, a master mold 10 is prepared, the master mold 10 has a reference plane 11 and a plurality of holes 12, and the plurality of holes 12 are recessed downward from the datum plane 11, and the plurality of holes A plurality of holes 12 are recessed on the master mold 10 in a matrix arrangement. In this embodiment, the material of the master mold 10 is PDMS, and the hole density on the master mold 10 is 289 holes / cm 2 , the hole array range is 1.5cm × 1.5cm, the shape of each hole 12 is a square cone, its depth (that is, the vertical distance between the end of the hole 12 and the reference plane 11) is 750 μm, and the maximum width (that is, the hole 12 and the reference plane 11 The maximum inner diameter of the flush horizontal plane) is 300 μm.

[0070] Then, ...

Embodiment 2

[0078] In this example, the medical beauty microneedle patch is generally prepared by the method described in Example 1 above. The main difference is that in this example, the needle-tip mixed solution and the needle-bottom mixed solution are coated by the scraper coating method. , fix the needle base mixture in multiple holes in a centrifugal manner, and omit the step of scraping the needle base mixture.

[0079] Specifically, after the step (a), the step (b1) is performed using a doctor blade coating method, and the needle-tip mixture is coated on the master mold with a coating gap of 1000 μm and a coating speed of 3 m / min; Then through steps (b2) to (b4) and (c) as described in Example 1 in sequence, a master mold with a pinpoint layer was obtained. The needle tip mixture is an aqueous solution of 20wt% blue copper peptide and methyl vinyl ether-maleic anhydride copolymer, and the needle tip mixture is heated at 25°C for 1S -1 The measured viscosity is 40cP, and its surfac...

Embodiment 3

[0083] In this example, the medical beauty microneedle patch is generally prepared by the method described in Example 1 above. The main difference is that in this example, the needle-tip mixed solution and the needle-bottom mixed solution are coated by the scraper coating method. In addition, change the structure of the master mold and omit the step of scraping off the mixed liquid at the bottom of the needle. In addition, the composition of the needle-tip mixture used in this embodiment is also different from the composition of the needle-tip mixture in Example 1. For the detailed production process of this embodiment, please refer to Figure 4 As shown, the following will match figure 1 and Figure 4 The production method of this example will be described.

[0084] First, if figure 1 and Figure 4 In step (a) shown, a master mold 10 is prepared, and the master mold 10 has a reference plane 11 and a plurality of holes 12 . In this embodiment, the material of the master ...

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Abstract

The invention relates to a preparing method of a cosmetic medical microneedle paster. The method includes firstly forming a needle top liquid mixture containing a cosmetic medical active component in a plurality of holes of a female die; drying the mixture to form a needle top layer; then forming a needle bottom liquid mixture in the plurality of holes and on the needle top layer; then drying the needle bottom liquid mixture to form a needle bottom layer so that the needle bottom layer is adhered to the needle top layer; and finally dismounting the needle top and bottom layered which are adhered to each other from the female die to obtain the plaster. The method overcomes problems of adhesion, machine position aligning, and production costs in microneedle paster manufacturing in the prior art, saves process time, and increases the efficiency of mass production. The preparing method suitable for large-scale production of the cosmetic medical microneedle paster is provided.

Description

technical field [0001] The invention relates to a production technology of medical products, in particular to a production method of a medical aesthetic microneedle patch. Background technique [0002] Transdermal drug delivery is a drug delivery method that has attracted attention in recent years. It can use a non-invasive drug delivery method to allow drugs to be absorbed through the skin to exert their efficacy. Although transdermal drug delivery can avoid the inability to effectively control the efficacy of oral drug due to the effect of the digestive system, and at the same time avoid the fear and pain caused by subcutaneous injection, but because the stratum corneum of the skin is both hydrophobic and negatively charged, Therefore, it is not suitable for delivering water-soluble drugs through the transdermal drug delivery system. [0003] In response to the above problems, a microneedle patch has been developed in the prior art, and its substrate is covered with multi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0053
Inventor 吴佳育徐英华
Owner WIN COAT CORP
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