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Citrate modified up-conversion luminescent nano material and preparation method thereof, hydrogen peroxide or uric acid detection method and applications

A citrate and detection method technology, applied in the direction of luminescent materials, material analysis by optical means, nanotechnology for materials and surface science, etc., can solve the problems of time-consuming and labor-intensive, complicated experimental steps, low sensitivity, etc.

Active Publication Date: 2017-10-24
ANHUI NORMAL UNIV
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  • Claims
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Problems solved by technology

However, the existing detection methods have problems such as high detection limit, low sensitivity, complicated experimental steps, time-consuming and labor-consuming, and expensive instruments.

Method used

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  • Citrate modified up-conversion luminescent nano material and preparation method thereof, hydrogen peroxide or uric acid detection method and applications
  • Citrate modified up-conversion luminescent nano material and preparation method thereof, hydrogen peroxide or uric acid detection method and applications
  • Citrate modified up-conversion luminescent nano material and preparation method thereof, hydrogen peroxide or uric acid detection method and applications

Examples

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preparation example Construction

[0030] The invention provides a citrate modified NaYF 4 : Yb, the preparation method of Er / Mn up-conversion luminescence nano material, this preparation method comprises:

[0031] 1) Stir alkali, water, oleic acid, C1-C3 alcohol, manganese source, ytterbium source, yttrium source, erbium source and NaF, followed by hydrothermal reaction and centrifugation to obtain OA-NaYF 4 : Yb, Er / Mn UCNPs (NaYF coated with oleic acid 4 : Yb, Er / Mn up-conversion nanomaterial);

[0032] 2) Add OA-NaYF 4 :Yb, Er / Mn UCNPsOA-NaYF 4 : Yb, Er / Mn upconversion nanoparticles dispersed in alcohol, followed by ligand exchange reaction with chloroform and citrate solution to obtain citrate-modified NaYF 4 : Yb, Er / Mn UCNPs upconverting nanoparticles.

[0033] In step 1) of the present invention, the consumption of each material can be selected in a wide range, but in order to improve NaYF 4 : Yb, Er / Mn up-conversion luminescent nanomaterial yield, preparation rate and prepared citrate-modified Na...

Embodiment 1

[0054] 1) OA-NaYF 4 : Yb, Er / Mn up-conversion nanomaterials (OA-NaYF 4 :Yb, the preparation of Er / Mn UCNPs):

[0055] First, weigh 0.300g of NaOH and place it in a 50mL beaker, then add 1.50mL of ultrapure water, 5.00mL of oleic acid, 10.0mL of ethanol, stir well and then add 0.500mL of MnCl 2 solution (0.600mol / L), 1.00mL Y(NO 3 ) 3 solution (0.500mol / L), 0.900mL YbCl 3 solution (0.200mol / L) and 0.100mL Er(NO 3 ) 3 solution (0.200mol / L). Then, 4.00 mL of NaF solution (1.00 mol / L) was added dropwise and stirred gently at 25 °C for 15 min, then transferred to a 50 mL reactor, and reacted at 200 °C for 8 h. After natural cooling to 25°C, centrifuge (10000rmp, centrifuge for 5min), and finally wash repeatedly with ultrapure water and ethanol several times to obtain OA-NaYF 4 : Yb, Er / Mn upconversion nanomaterials.

[0056] 2) Citrate-modified NaYF 4 : Preparation of Yb,Er / Mn up-conversion luminescent nanomaterials:

[0057] 30.0 mg oleic acid-coated NaYF 4 Dissolve Yb...

Embodiment 2

[0059] According to the method of Example 1, citrate-modified NaYF4:Yb, Er / Mn up-conversion luminescent nanomaterial A2 was prepared, except that MnCl 2 The concentration of manganese ions in the solution is 0.4mol / L.

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Abstract

The invention discloses a preparation method of citrate modified NaYF4:Yb,Er / Mn up-conversion luminescent nano material, a hydrogen peroxide or uric acid detection method and applications. The preparation method comprises the following steps: 1) stirring alkali, water, oleic acid, C1-C3 alcohol, a manganese source, a ytterbium source a yttrium source, an erbium source and NaF, and then carrying out hydrothermal reaction and centrifugal separation to obtain OA-NaYF4:Yb,Er / Mn UCNPs; and 2) dispersing OA-NaYF4:Yb, Er / Mn UCNPs in alcohol, and then carrying out ligand exchange reaction with a trichloromethane and citrate solution to obtain the citrate modified NaYF4:Yb,Er / Mn up-conversion luminescent nano material. The citrate modified NaYF4:Yb,Er / Mn up-conversion luminescent nano material has the advantages of low detection limit, high sensitivity and good selectivity to hydrogen peroxide or uric acid detection, so that the material can be used for detecting uric acid in serum.

Description

technical field [0001] The invention relates to an up-conversion luminescent nanometer material, in particular to a preparation method of a citrate-modified upconversion luminescent nanometer material, a detection method and application of hydrogen peroxide or uric acid. Background technique [0002] Uric acid is a biomolecule and a metabolite of purines in the human body. For healthy people, the concentration of uric acid in serum is in the range of 0.12-0.46mmol / L. Once the uric acid level exceeds this range, it may lead to many diseases, such as gout, hypertension, leukemia, kidney disease and cardiovascular disease. Therefore, early detection of uric acid has very important clinical significance for the prevention, diagnosis and treatment of the above diseases. Among the many detection methods that have been created, fluorescence method is the main method to detect uric acid. However, the existing detection methods have problems such as high detection limit, low sensit...

Claims

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Application Information

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IPC IPC(8): C09K11/06C09K11/85G01N21/64B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00C09K11/06C09K11/7773G01N21/6402G01N21/6428G01N2021/6432
Inventor 陈红旗周瑶瑶
Owner ANHUI NORMAL UNIV
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