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Gelatin protective agent for chicken infectious laryngotracheitis recombined avian pox virus live vaccine

A technology for laryngotracheitis and fowlpox virus, which is applied in the field of vaccine preparation, can solve problems such as low solubility, loose skeleton, and excessive moisture in the product, and achieve the effect of simple components, easy dissolution, and uniform appearance

Inactive Publication Date: 2017-10-24
YANGLING LVFANG BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the recombinant fowlpox genetically engineered live vaccine of chicken infected with laryngotracheitis is prepared with gelatin protective agent, which has problems such as excessive moisture, loose skeleton and low solubility.

Method used

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  • Gelatin protective agent for chicken infectious laryngotracheitis recombined avian pox virus live vaccine
  • Gelatin protective agent for chicken infectious laryngotracheitis recombined avian pox virus live vaccine
  • Gelatin protective agent for chicken infectious laryngotracheitis recombined avian pox virus live vaccine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] In order to solve the shortcomings of too much water, loose skeleton and low solubility in the recombinant fowlpox virus live vaccine product of chicken infection laryngotracheitis, experiments were designed with different contents of gelatin, and the approximate content range of gelatin in the vaccine product was determined. As shown in Table 1:

[0015] The performance of the vaccine product prepared in the embodiment 1 of table 1

[0016]

[0017] From the parameters in Table 1, it can be seen that when the gelatin content per 100ml of the vaccine product is 0.5-1.5g, the vaccine product meets the basic performance requirements.

Embodiment 2

[0019] According to the content range of gelatin in the product determined in embodiment 1, promptly select the scope of gelatin content in 0.5~1.5g in every 100ml vaccine product, do embodiment 2, to determine the optimal content of gelatin in the vaccine product. The performance of prepared vaccine product is as shown in table 2:

[0020] The performance of the vaccine product prepared in the embodiment 2 of table 2

[0021]

[0022]

[0023] It can be seen from Table 2 that the properties of the vaccine products with gelatin content of 0.85g and 1.0g are good. Based on the combination of moisture and solubility, it can be seen that the gelatin content of 0.85g per 100ml of vaccine products has the best performance.

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Abstract

The invention discloses a gelatin protective agent for chicken infectious laryngotracheitis recombined avian pox virus live vaccine. The gelatin protective agent is prepared from the following components: gelatin, saccharose and sterile injection water, wherein each 100ml of the gelatin protective agent is prepared from 4.25g of the gelatin, 25g of the saccharose, and the balance of the sterile injection water. The chicken infectious laryngotracheitis recombined avian pox virus live vaccine using the gelatin protective agent is easy to dissolve and fall off, and the appearance is uniform and flat.

Description

technical field [0001] The invention belongs to the technical field of vaccine preparation, and in particular relates to a gelatin protective agent for recombinant fowlpox virus live vaccine of chicken infectious laryngotracheitis. Background technique [0002] Protective agents refer to additives other than antigenic substances in freeze-dried biological products. They are substances that protect the activity and antigenicity of bacteria, viruses and other microorganisms so that they are not or less damaged during the freezing and drying process. Due to the different types of microorganisms, the protective agent has various formulations, and different protective agents have different protective effects on different microorganisms. Commonly used protective agents mainly include milk protective agents, gelatin protective agents and new heat-resistant protective agents. [0003] At present, the recombinant fowl pox genetically engineered live vaccine of chicken infected with ...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/26A61K39/215A61P31/14
CPCA61K39/215A61K47/26A61K47/42
Inventor 樊军喜
Owner YANGLING LVFANG BIOLOGICAL ENG CO LTD
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