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Preparation method of high-efficiency cyhalothrin nano-pesticide

A technology of lambda-cyhalothrin and nano-pesticides, which is applied to botany equipment and methods, preservation of human or animal bodies, insecticides, etc., to achieve good permeability, simple preparation method, and good environmental compatibility Effect

Active Publication Date: 2017-10-24
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Beta-cyhalothrin, also known as cyhalothrin trifluthrin, kung fu permethrin, etc., chemical name: 3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethyl α-cyano-3-phenoxybenzyl cyclopropanecarboxylate has a broad insecticidal spectrum, high activity, rapid drug effect, and is resistant to rain after spraying. Pests with mouthparts and harmful mites have a certain control effect, but the dosage for mites should be increased by 1-2 times compared with the conventional dosage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] According to the mass ratio of the drug to the amphiphilic copolymer as 1:5, 2% of lambda-cyhalothrin was added to the dichloromethane solution of 0.5-10% chitosan-polylactic acid graft copolymer, and the ultrasonic wave was completely After dissolving, add dropwise into 1% polyvinyl alcohol (PVA) solution (the volume ratio of the two solutions is 1:10), stir at a speed of 500r / min for 10min, and ultrasonically break the mixture for 5min to obtain oil-in-water (W / O) The emulsion is obtained by rotary evaporation to remove the organic solvent to prepare a nano-preparation of 80-150nm lambda-cyhalothrin with a drug loading of 10-30%, and the encapsulation rate is greater than 75%. The nano-preparation can also be centrifuged and freeze-dried to obtain a solid nano-preparation of lambda-cyhalothrin.

[0020] The nano-pesticides prepared in this example have smaller and more uniform particle sizes, better permeability, and a certain slow-release effect, which prolongs the d...

Embodiment 2

[0022] Accurately weighed lambda-cyhalothrin and chitosan-polylactic acid graft copolymer were dissolved in acetone, respectively, and ultrasonically dissolved to prepare acetone solutions with concentrations of 1 mg / mL and 10 mg / mL, respectively. Mix according to the mass ratio of the drug to the amphiphilic copolymer at 1:5, drop into 10mL of deionized water, stir at a speed of 500r / min for 10min, stir evenly to form a drug-loaded micellar solution with protein light, and rotate to evaporate the organic solvent Finally, a nano-preparation of 60-130nm lambda-cyhalothrin with a drug load of 20-40% is prepared, and the encapsulation rate is greater than 80%. The nano-preparation can also be centrifuged and freeze-dried to obtain a solid nano-preparation of lambda-cyhalothrin.

[0023] The nano-pesticides prepared in this example have smaller and more uniform particle sizes, better permeability, and a certain slow-release effect, which prolongs the duration of pyrethroid pestici...

Embodiment 3

[0025] According to the mass ratio of the drug to the amphiphilic copolymer as 1:50, 4% lambda-cyhalothrin was added to the chloroform solution of 1-10% chitosan-polylactic acid graft copolymer, and the ultrasonic wave was completely After dissolving, add dropwise into 1% polyvinyl alcohol (PVA) solution (the volume ratio of the two solutions is 1:10), stir at a speed of 600r / min for 8min, and ultrasonically crush the mixture for 3min to obtain oil-in-water (W / O) The emulsion is obtained by rotary evaporation to remove the organic solvent to prepare a nano-preparation of 70-120nm lambda-cyhalothrin with a drug loading of 15-40%, and the encapsulation rate is greater than 85%. The nano-preparation can also be centrifuged and freeze-dried to obtain a solid nano-preparation of lambda-cyhalothrin.

[0026] The nano-pesticides prepared in this example have smaller and more uniform particle sizes, better permeability, and a certain slow-release effect, which prolongs the duration of...

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Abstract

The invention discloses a preparation method of high-efficiency cyhalothrin nano-pesticide, belonging to the technical field of preparation of agricultural chemicals. The preparation method is characterized in that an amphiphilic copolymer is adopted and is self-assembled in an aqueous solution to form a nano-sized micelle with an obvious core-shell structure; the nano-pesticide is obtained by physical actions of an organic solvent and polyvinyl alcohol. The preparation method disclosed by the invention is simple and convenient; raw materials are easily obtained; a used solvent is water, so the pollution is small and the cost is low; the used amphiphilic copolymer has good environmental compatibility, biodegradation and no residual risks; in addition, a degraded product can be absorbed and utilized by crops; the nano-pesticide has the advantages of relatively small and relatively uniform particle size, relatively good permeability and certain slow release effect; the lasting period of pyrethroid pesticides is prolonged, and the using dose of the pesticide is reduced.

Description

technical field [0001] The invention belongs to the technical field of preparation of agricultural chemicals, and in particular relates to a preparation method of lambda-cyhalothrin nanopesticide. Background technique [0002] Pyrethroids are a class of broad-spectrum insecticides used to control a variety of sanitary pests and field pests. Generally speaking, their efficacy is better than traditional insecticides such as organophosphates and carbamates. The main effect is stomach poisoning. When the drug enters the insect body, it can excite or block the normal physiological signal transduction of the insect's nerves, causing it to produce neurological symptoms and die. [0003] Beta-cyhalothrin, also known as cyhalothrin trifluthrin, kung fu permethrin, etc., chemical name: 3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethyl α-cyano-3-phenoxybenzyl cyclopropanecarboxylate has a broad insecticidal spectrum, high activity, rapid drug effect, and is resistant to rain after sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N53/08A01N25/26A01P7/04
CPCA01N25/26A01N53/00A01N2300/00
Inventor 梅向东张开心宁君折冬梅杨帅王安佳
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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