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Sodium alginate/hydroxymethyl cellulose/gelatin interpenetrating polymer network gradient cross-linking type medical wound transparent dressing and preparation method thereof

A technology of hydroxymethyl cellulose and interpenetrating network, applied in the field of medicine, can solve the problems of foreign body reaction, ingredient allergy, high product cost, etc., and achieve the effects of good biocompatibility, simple preparation process, and low production cost

Inactive Publication Date: 2017-10-20
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its main disadvantages are as follows: 1. Unable to keep the wound surface moist, and the wound healing is delayed; 2. The dressing fiber is easy to fall off, causing foreign body reaction and affecting the healing; 3. The wound granulation tissue is easy to grow into the mesh of the dressing, which may cause pain when changing the dressing; 4. When the dressing is soaked, pathogens can easily pass through; 5. When changing the dressing, it is easy to damage the new tissue; 6. The workload of changing the dressing is heavy, etc.
But there are also disadvantages: the absorption capacity is not very strong, and for highly exudative wounds, it is often necessary to use other auxiliary dressings to enhance the absorption performance; the product cost is high; individual patients may be allergic to ingredients
However, glutaraldehyde is used as the cross-linking agent, which is toxic to the human body and has certain potential safety hazards.

Method used

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  • Sodium alginate/hydroxymethyl cellulose/gelatin interpenetrating polymer network gradient cross-linking type medical wound transparent dressing and preparation method thereof
  • Sodium alginate/hydroxymethyl cellulose/gelatin interpenetrating polymer network gradient cross-linking type medical wound transparent dressing and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Sodium alginate, hydroxymethylcellulose and gelatin were weighed according to 5.0% of the mass of distilled water. The masses of sodium alginate, hydroxymethylcellulose and gelatin are 1.0 g, 1.0 g and 1.0 g, respectively. Add it into distilled water at 20°C and stir to dissolve evenly to obtain a sodium alginate / hydroxymethylcellulose / gelatin blend solution. Prepare sodium alginate as a 5.0% aqueous solution, add equimolar sodium periodate and stir in the dark for 12 hours, add ethylene glycol to terminate the reaction for 1 hour, add NaCl for mixing, and then add an equal volume of ethanol to precipitate the product. The product was filtered with an equal volume of C 2 h 5 OH / H 2 O and C 2 h 5 Rinse with OH and dry in vacuum for 24h. Add 1.5g of 1,2-propanediol and 1.5g of glycerin into the sodium alginate / hydroxymethylcellulose / gelatin blend solution, stir evenly, add 1.0g of oxidized sodium alginate and 2.0g of PEGDMA, stir in distilled water at 20°C Dissolve...

Embodiment 2

[0025] Sodium alginate, hydroxymethylcellulose and gelatin were weighed according to 5.0% of the mass of distilled water. The masses of sodium alginate, hydroxymethylcellulose and gelatin are 1.0 g, 1.0 g and 1.0 g, respectively. Add it into distilled water at 20°C and stir to dissolve evenly to obtain a sodium alginate / hydroxymethylcellulose / gelatin blend solution. Prepare sodium alginate as a 5.0% aqueous solution, add equimolar sodium periodate and stir in the dark for 12 hours, add ethylene glycol to terminate the reaction for 1 hour, add NaCl for mixing, and then add an equal volume of ethanol to precipitate the product. The product was filtered with an equal volume of C 2 h 5 OH / H 2 O and C 2 h 5Rinse with OH and dry in vacuum for 24h. Add 1.5g of 1,2-propanediol and 1.5g of glycerin into the sodium alginate / hydroxymethylcellulose / gelatin blend solution, stir evenly, add 1.0g of oxidized sodium alginate and 2.0g of PEGDMA, stir in distilled water at 20°C Dissolve ...

Embodiment 3

[0027] Sodium alginate, hydroxymethylcellulose and gelatin were weighed according to 5.0% of the mass of distilled water. The masses of sodium alginate, hydroxymethylcellulose and gelatin are 1.0 g, 1.0 g and 1.0 g, respectively. Add it into distilled water at 20°C and stir to dissolve evenly to obtain a sodium alginate / hydroxymethylcellulose / gelatin blend solution. Prepare sodium alginate as a 5.0% aqueous solution, add twice the molar ratio of sodium periodate and stir in the dark for 12 hours, add ethylene glycol to terminate the reaction for 1 hour, add NaCl for mixing, and then add an equal volume of ethanol to precipitate the product. The product was filtered with an equal volume of C 2 h 5 OH / H 2 O and C 2 h 5 Rinse with OH and dry in vacuum for 24h. Add 1.5g of 1,2-propanediol and 1.5g of glycerin into the sodium alginate / hydroxymethylcellulose / gelatin blend solution, stir evenly, add 1.0g of oxidized sodium alginate and 2.0g of PEGDMA, stir in distilled water at...

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Abstract

The invention discloses a sodium alginate / hydroxymethyl cellulose / gelatin interpenetrating polymer network gradient cross-linking type medical wound transparent dressing and a preparation method thereof. According to the invention, the sodium alginate / hydroxymethyl cellulose / gelatin interpenetrating polymer network gradient cross-linking type medical wound transparent dressing is prepared in the manner of the physical chemical cross-linking action of sodium alginate and PEGDMA, hydroxymethyl cellulose, gelatin and calcium ions and the chemical cross-linking action of oxidized sodium alginate and gelatin. The raw materials are harmless to a human body, the preparation method is simple and the medical wound transparent dressing has the characteristics of high flexibility, excellent biocompatibility, and the like.

Description

technical field [0001] The invention relates to a sodium alginate / hydroxymethylcellulose / gelatin interpenetrating network gradient cross-linked medical wound transparent dressing and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Modern medical theory proves that the wound healing process is a continuous dynamic process, which is a process of interaction between cells and cells, cells and cell matrix, and soluble media. As part of wound care, a good medical dressing should provide a suitable environment for wound healing, thereby speeding up wound healing and improving the quality of wound healing. Traditional dressings can only passively cover the wound and absorb exudate, providing limited protection for the wound. Generally, it is made of cotton, burlap and linen, and has no obvious effect on wound healing. Its main disadvantages are as follows: 1. Unable to keep the wound surface moist, and the wound healing is...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/28A61L15/32A61L15/18C08J3/24C08L5/04C08L1/28C08L71/02C08L89/00
CPCA61L15/18A61L15/28A61L15/32A61L15/42A61L2400/04C08J3/24C08J2301/28C08J2305/04C08J2389/00C08L5/04C08L1/286C08L89/00
Inventor 马贵平李哲夫李禄禄高易陈绍山
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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