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Sandwich type composite membrane stent

A sandwich-type, composite membrane technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of directional drug release and low drug loading, and achieve the effect of improving the effect of action

Inactive Publication Date: 2017-10-17
无锡市锡山人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] 2. Provide a new drug loading system to solve the problem of directional drug release and low drug loading

Method used

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  • Sandwich type composite membrane stent
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  • Sandwich type composite membrane stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] refer to figure 1 , 2 , a sandwich-type composite membrane scaffold, including a dense outer layer, a sandwich layer and an inner layer from top to bottom, the dense outer layer is a polylactic acid film (PLA film), and the sandwich layer is loaded with nerve growth stimulating factor Mesoporous bioactive glass beads, the inner layer is a chitosan film (CS film) loaded with HUMSCs, and the support is square. The periphery of the composite membrane support is sealed with medical bio-glue, and the biologically active factor loaded in the sandwich layer is a nerve growth stimulating factor. The dense outer layer is used to block the active factors and stem cells of the sandwich layer and the inner layer from penetrating into this aspect and seeping out to the outside through the membrane. At this time, active factors and stem cells can only move to the spinal cord injury (such as image 3 ), to achieve the purpose of only providing stem cells and active factors to the s...

Embodiment 2

[0037] Compared with Example 1, the difference of Example 2 is that the mesoporous bioactive glass spheres are replaced by ethylene glycol lactic acid copolymer (PEG-PLA) nano microspheres.

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PUM

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Abstract

The invention provides a sandwich-type composite membrane support, comprising a dense outer layer, a sandwich layer and an inner layer from top to bottom, the dense outer layer is a polylactic acid film, and the sandwich layer is a mesoporous organism loaded with biologically active factors Active glass spheres, the inner layer is a chitosan membrane loaded with seed cells. In order to solve the problem that the single nerve bundle that has been damaged (but not dead) cannot be repaired and treated by the existing technology; the existing drug-loaded system cannot achieve the directional release of the drug and cannot guarantee the high concentration of the damaged local factor; most loading The drug system is easy to degrade, the drug loading is low, and the drug release cannot run through the repair process of spinal cord injury. The drug loading system is too large, which may compress the spinal cord, and is not conducive to suturing the dura mater, resulting in the formation of cerebrospinal fluid leakage.

Description

technical field [0001] The invention relates to a sandwich composite membrane support. Background technique [0002] Currently, the most common route of administration of nerve growth-promoting or nerve regenerative drugs is intravenous or intrathecal injection. There are also gel-binding active factor patches applied on the surface of the spinal cord, and L-polylysine-binding active factor as a scaffold implanted in the spinal cord to solve the problem of factors passing through the blood-brain barrier. [0003] Both drug delivery systems and stem cell bioscaffolds can be used to treat spinal cord injuries, but the combination of the two has not been seen so far. A similar combination has been used in the method and material of stem cell three-dimensional scaffold for bridging nerves, such as (a composite repair material and its scaffold for bridging defective nerves CN201510716279.8). However, the current treatment methods for bridging nerves with three-dimensional sca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/20A61L27/10A61L27/18A61L27/54A61L27/22A61L27/38A61L27/50
CPCA61L27/20A61L27/10A61L27/18A61L27/227A61L27/3834A61L27/50A61L27/54A61L2300/412A61L2300/602A61L2430/32
Inventor 顾军范健纪立军宋晓丽冯晓军徐林
Owner 无锡市锡山人民医院
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