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Medicine preparation with immunity-enhancing and anti-tumor effects, preparation method and application thereof

A pharmaceutical preparation and anti-tumor technology, applied in the field of traditional Chinese medicine compositions, can solve the problems of large adverse reactions of patients, high toxicity of chemotherapy drugs, low survival rate, etc., and achieve the effects of improving immunity, significant curative effect and reasonable compatibility.

Inactive Publication Date: 2017-10-10
青海九康中药饮片有限公司
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

Clinically, the current drugs for treating tumors mainly include chemical drugs. However, due to the high toxicity of chemotherapy drugs, they can not selectively kill white blood cells, lymphocytes and other human immune cells while killing tumor cells. As a result, patients often suffer from autoimmune diseases. Complicated infection due to low ability, severe adverse reactions, low survival rate and high cost

Method used

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  • Medicine preparation with immunity-enhancing and anti-tumor effects, preparation method and application thereof

Examples

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Effect test

preparation example Construction

[0036] 2. The preparation method of the pharmaceutical preparation with improving immunity and anti-tumor effect according to the present invention, which comprises the following steps:

[0037] (1) Get 120 parts of Radix Astragali, 20 parts of Dendrobium, 60 parts of Atractylodes macrocephala, 80 parts of Polyporus sativa, 10 parts of saffron, 60 parts of Salvia miltiorrhiza, 40 parts of Panax notoginseng, 10 parts of dandelion, 10 parts of palmetto, 10 parts of root, 10 parts of Sophora flavescens, 10 parts of Fangji, 15 parts of camptophyllum, 10 parts of goose herbivore, 15 parts of Brucea javanica, 10 parts of Lycoris, add 12 times the amount of ethanol to extract 3 times, each time Concentrate under reduced pressure and vacuum for 2 hours, add ethanol so that the volume concentration of ethanol is 85%, let stand, filter, and take the filtrate to obtain a concentrate;

[0038] (2) Get 3 parts of bezoar, 4 parts of leech, 10 parts of silkworm, 25 parts of ground beetle, 4 ...

Embodiment 1

[0061] The compound Chinese medicine extract prepared in Example 1 and Example 2; sheep red blood cells (provided by Guangzhou Ruite Biotechnology Co., Ltd.); guinea pig serum (provided by Guangzhou Ruite Biotechnology Co., Ltd.); the kit was provided by Nanjing Jiancheng Bioengineering Institute Provided; other reagents were of domestic analytical grade.

[0062] 1.3 Experimental Instruments

[0063] Freeze dryer (LABCONCO, USA), UV spectrophotometer (Beijing Labtech Instrument Co., Ltd.), microplate reader (PerkinElmer Co., Ltd.), automatic blood cell analyzer (Sysmex Corporation, Japan), electronic balance (Sartorius Scientific Instruments Ltd.).

[0064] 2. Experimental method

[0065] 2.1 Modeling and administration of immunocompromised mice

[0066] 70 mice, half male and half male, were weighed and numbered, and randomly divided into 4 groups, including a blank group, a model group, and the compound Chinese medicine extracts prepared in Example 1 and Example 2. On t...

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Abstract

The invention discloses a medicine preparation with immunity-enhancing and anti-tumor effects. The medicine preparation comprises the following raw materials in parts by weight: astragalus membranaceus 6, dendrobe, bighead atractylodes rhizome, grifola, saffron crocus, salviae miltiorrhizae, pseudo-ginseng, dandelion, Chinese fan palm, subprostrate sophora, radix sophorae flavescentis, tetrandra root, camptotheca acuminate, centipeda minima, brucea javanica, short-tube lycoris, bezoar, leech, stiff silkworm, ground beeltle, centipede, cinnabar and toad skin. The traditional Chinese medicine formula is screened by adopting the theory of diagnosis and treatment according to the traditional Chinese medicine theory; the traditional Chinese medicine compositionisscientific and reasonable in ratio; an experimental result proves that the traditional Chinese medicine composition provided by the invention has excellent effects of inhibiting tumor cell growth and boosting tumor cell apoptosis, has strong killing effect for various malignant cells and is wide in application scope; the traditional Chinese medicine composition can obviously enhance immunity and can strengthen physique; and a long-term test research shows that the traditional Chinese medicine composition provided by the invention is high in safety, is low in toxic side effect and can be used for developing a new antitumor drug.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a pharmaceutical preparation with the effect of improving immunity and anti-tumor, and belongs to the technical field of medicine and pharmacy. Background technique [0002] Tumor has become the number one killer threatening human existence in the 21st century. China is one of the countries with high incidence of cancer in the world, and it shows a rapid growth trend every year. Clinically, the current drugs for treating tumors mainly include chemical drugs. However, due to the high toxicity of chemotherapy drugs, they can not selectively kill white blood cells, lymphocytes and other human immune cells while killing tumor cells. As a result, patients often suffer from autoimmune diseases. Complicated infection due to low ability, severe adverse reaction, low survival rate and high cost. [0003] Traditional Chinese medicine has unique advantages in the treatment of t...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P35/00A61P37/04A61K33/28A61K35/413A61K35/65A61K35/62A61K35/64A61K35/648
CPCA61K36/889A61K36/8984A61K33/28A61K35/413A61K35/62A61K35/63A61K35/648A61K35/65A61K36/07A61K36/185A61K36/258A61K36/28A61K36/284A61K36/288A61K36/481A61K36/489A61K36/537A61K36/59A61K36/88A61K2236/39A61K2236/53A61K2236/33A61K2300/00
Inventor 李成龙李志成程海波孙东东沈卫星李柳曹岗苗筠杰谭佳妮徐长亮
Owner 青海九康中药饮片有限公司
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