Novel hyaluronic acid binding peptide (HaBP) and transdermal absorption and subcutaneous targeted release preparation

A hyaluronic acid and peptide-binding technology, applied in skin care preparations, hybrid peptides, polypeptides containing positioning/targeting motifs, etc., can solve the problem of low skin penetration rate and achieve the effect of promoting cell proliferation

Active Publication Date: 2017-10-03
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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Problems solved by technology

However, as a biomacromolecule, the low skin penetration rate has been a major problem plaguing its practical application.

Method used

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  • Novel hyaluronic acid binding peptide (HaBP) and transdermal absorption and subcutaneous targeted release preparation
  • Novel hyaluronic acid binding peptide (HaBP) and transdermal absorption and subcutaneous targeted release preparation
  • Novel hyaluronic acid binding peptide (HaBP) and transdermal absorption and subcutaneous targeted release preparation

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Embodiment Construction

[0024] The present invention will be further described in detail below through the specific examples, the following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention with this.

[0025] The invention is to design a novel hyaluronic acid-binding peptide (HaBP) and a method for promoting transdermal absorption and subcutaneous targeted release of hyaluronic acid. According to the structural characteristics of hyaluronic acid-binding protein, design HaBP that can specifically bind to hyaluronic acid (HA), incubate and mix the HaBP with cell-penetrating peptide and HA under certain conditions, and mix HaBP, cell-penetrating peptide, The three parts of the subcutaneous endogenous protease cleavage site are connected together to construct a fusion protein and then incubated with HA, which can significantly promote the transmembrane transport and transdermal absorption of hyaluronic acid, and realize the targeted release of ...

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Abstract

The invention provides a novel hyaluronic acid binding peptide (HaBP) and a transdermal absorption and subcutaneous targeted release preparation. The HaBP can be specifically bound with hyaluronic acid (HA). When the HaBP, cell-penetrating peptides and HA are subjected to incubation and mixing under certain conditions or when the HaBP, cell-penetrating peptides and a subcutaneous endogenous proteinase restriction enzyme cutting site are connected together to construct a fusion protein and the fusion protein and HA are subjected to incubation, the transmembrane transport and transdermal absorption of the HA can be obviously promoted, and the subcutaneous targeted release of the HA can be implemented. The method provided by the invention overcomes the defect of low transdermal absorptivity when the HA is used as a biomacromolecular substance, so that the HA can efficiently go through the skin cuticle and perform subcutaneous targeted release to promote cell proliferation so as to perform the actual functions in the aspects of skin care, moisturizing, wrinkle reduction, whitening and the like, thereby providing a new idea and new method for development and production of related cosmetic products and biological drugs.

Description

technical field [0001] The invention belongs to the field of cosmetics and biomedicine, and relates to a novel hyaluronic acid-binding peptide and a method for promoting transdermal absorption and subcutaneous targeted release of hyaluronic acid and its application in cosmetics and biomedicine. Background technique [0002] Hyaluronic acid (Hyaluronic acid, HA) is a straight-chain polymer polysaccharide widely present in the connective tissue of organisms. It is one of several glycosaminoglycans that make up the extracellular matrix. It has the most content in joint synovial fluid and has important physiological functions such as water retention and lubrication. It is natural, non-allergic and has good biocompatibility with human tissues, and is widely used in the fields of cosmetics, health food, cosmetic surgery and medicine. However, as a biomacromolecule, the low skin penetration rate has been a major problem plaguing its practical application. Cell-penetrating peptide...

Claims

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Application Information

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IPC IPC(8): C07K14/00C07K19/00A61K8/64A61K8/73A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/64A61K8/735A61Q19/00A61Q19/02A61Q19/08C07K14/00C07K2319/03C07K2319/50
Inventor 罗学刚张同存闫莉华王玥张宇洁乔丽萍
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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