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Piperazine phosphate controlled-release agent and preparation method thereof

A technology of piperazine phosphate and slow-release agent, which is applied in the directions of pill delivery, pharmaceutical formulation, coating, etc., can solve the problems of too fast release of piperazine phosphate tablets and poor repellent effect, etc., and achieves improved repellent effect and extended time. , the effect of short process

Inactive Publication Date: 2017-09-29
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: the existing piperazine phosphate tablet releases too fast and has poor insect repelling effect

Method used

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  • Piperazine phosphate controlled-release agent and preparation method thereof
  • Piperazine phosphate controlled-release agent and preparation method thereof

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preparation example Construction

[0023] The invention provides a preparation method of piperazine phosphate slow-release agent, comprising the following steps:

[0024] a. Mix piperazine phosphate powder and oligosaccharide evenly in a weight ratio of 3-5:1-2, add edible gelatin accounting for 3-5wt% of the raw material weight, add water to a water content of 5-8%, and stir evenly to obtain material A ;

[0025] b. Compress material A into tablets to make uniform tablets;

[0026] c. Weigh raw materials by weight of 10-20 parts of polycation electrolyte, 10-20 parts of polyanion electrolyte, 30-35 parts of small molecule crosslinking agent, and 5-10 parts of oligosaccharide, mix them uniformly and add water to prepare 0.01- 0.02g / ml solution;

[0027] d. Spray the solution obtained in step c onto the surface of the tablet described in step b, and dry to form a coating film to prepare the piperazine phosphate sustained-release preparation.

[0028] Wherein, in the preparation method of the above-mentioned p...

Embodiment 1

[0042] Embodiment 1 prepares piperazine phosphate slow-release agent with the inventive method

[0043] Prepare piperazine phosphate slow-release agent, comprising the following steps:

[0044] a. Mix piperazine phosphate powder and oligosaccharide evenly in a weight ratio of 3:1, add edible gelatin accounting for 3wt% of the raw material weight, add water to a water content of 5%, stir evenly, and stir at 300r / s for 1h to obtain the material A;

[0045] b. Tablet the material A at 50°C and a pressure of 0.4Mpa to make a uniform tablet;

[0046] c, 10 parts by weight of mannan, 10 parts of xanthan gum, 30 parts of sodium tripolyphosphate, and 5 parts of oligosaccharides are weighed to prepare a 0.01 g / ml solution by adding water after mixing;

[0047] d. Spray the solution obtained in step c onto the surface of the tablet described in step b, and dry at 70° C. for 45 minutes to form a coating film to prepare the piperazine phosphate sustained-release preparation.

Embodiment 2

[0048] Embodiment 2 prepares piperazine phosphate slow-release agent with the inventive method

[0049] Prepare piperazine phosphate slow-release agent, comprising the following steps:

[0050] a. Mix piperazine phosphate powder and oligosaccharide evenly in a weight ratio of 5:1, add edible gelatin accounting for 4wt% of the raw material weight, add water to a water content of 7%, stir evenly, and stir at 350r / s for 1.5h during stirring to obtain Material A;

[0051] b. Tablet the material A at 60°C and a pressure of 0.45Mpa to make a uniform tablet;

[0052] c, 15 parts by weight of mannan, 15 parts of xanthan gum, 30 parts of sodium tripolyphosphate, 10 parts of oligosaccharides are weighed raw materials, mixed evenly, add water to prepare a 0.02g / ml solution;

[0053] d. Spray the solution obtained in step c onto the surface of the tablet described in step b, and dry at 80° C. for 50 minutes to form a coating film to prepare the piperazine phosphate sustained-release prepa...

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Abstract

The invention belongs to the field of biological medicines and particularly relates to a piperazine phosphate controlled-release agent and a preparation method thereof. The invention provides a piperazine phosphate controlled-release agent and a preparation method thereof for the problem that an existing piperazine phosphate table is too fast in release and poor in insect repellent effect. The method comprises the steps of (a) mixing piperazine phosphate powder and oligosaccharide at the weight ratio of (3-5):(1-2) evenly, adding edible gelatine which accounts for 3-5wt% of weight of the raw materials, adding water until the moisture content is 5-8 and mixing evenly to obtain a material A; (b) tabletting the material A to prepare a uniform tablet; (c) weighing the raw materials in parts by weight: 10-20 parts of a polycation electrolyte, 10-20 parts of a polyanion electrolyte, 30-35 parts of a small molecule crosslinking agent and 5-10 parts of oligosaccharide, mixing evenly and then adding water to prepare 0.01-0.02g / ml of solution; and (d) spraying the solution obtained in the step (c) on the surface of the tablet obtained in the step (b) and drying to form a coating membrane to prepare the piperazine phosphate controlled-release agent. The controlled-release agent is capable of prolonging the action time in an intestinal tract and strengthening the insect repellent effect and is suitable for promotion and use.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a piperazine phosphate slow-release agent and a preparation method thereof. Background technique [0002] Piperazine phosphate is also known as piperazine phosphate or piperazine phosphate monohydrate, with a chemical formula of C4H10N2H3PO4H2O and a molecular weight of 202.15. Piperazine phosphate pagoda sugar with piperazine phosphate as the main component is a traditional anthelmintic drug and one of the ideal anthelmintic drugs at present. The medicine has the advantages of high curative effect, low toxicity, easy usage and the like. Piperazine phosphate has the effect of paralyzing roundworms, and the mechanism of expelling roundworms may be that piperazine exerts an anticholinergic effect at the neuromuscular junction of the worm body, blocks the excitatory effect of acetylcholine on the muscles of roundworms, or changes the ionization of the muscle cell membrane of ...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/22A61K47/36A61K31/495A61P33/10
CPCA61K9/0002A61K9/286A61K31/495
Inventor 朱正标陶元明张汉华李苗苗范小雪
Owner 江苏黄河药业股份有限公司
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