Penicillium commune T3-1, fermentation compounds thereof, extraction and purification method and antiallergic application

Abstract

The invention discloses penicillium commune T3-1, fermentation compounds thereof, an extraction and purification method and an antiallergic application. Penicillium commune T3-1 is preserved in CCTCC (China Center for Type Culture Collection) in Wuhan University in Wuhan, China on March 15th, 2017, and the preservation number is CCTCC NO: M 2017123. The structures of the compounds obtained from Penicillium commune T3-1 through fermentation and extraction are shown as formulae (I) and (II) in the specification. Experiments discover that the compounds have higher antiallergic activity and can be used for preparing and developing antiallergic drugs. New compound sources are provided for research and development of the antiallergic drugs, and the compounds have great significance for development of marine drugs in China, can further promote effective application of deep-sea biological resources and have good application prospect.

Description

technical field [0001] The invention belongs to the field of new compounds extracted from marine fungi, more specifically, the invention relates to a new Penicillium commune T3-1 (Penicillium commune T3-1), a class of Penicillium commune fermentation compounds obtained by fermentation and extraction thereof, and corresponding The extraction and purification method and the application of Penicillium fermented compounds in anti-allergy. Background technique [0002] Food allergy, that is, food allergy, refers to the strong reaction of a certain tissue, a certain organ or even the whole body caused by some people after eating a certain food, resulting in various dysfunction or tissue damage, serious Or it may even cause anaphylactic shock. Food allergy is a threat to human life and health, and its incidence has gradually increased in the past few decades, and almost 10% of children suffer from food allergy. The Codex Alimentarius Commission states that common food allergens i...

AI Technical Summary

Problems solved by technology

[0003] The current treatment for food allergy is to avoid exposure to allergens or perform desensitization therapy, and no active drug that inhibits allergenic food antigens has been found

Dietary intervention is a crucial part of food allergy management, but it will have a negative impact on the nutritional intake and quality of life of the human body; and the use of antihistamines or hormone drugs is prone to side effects such as drug resistance, so Finding anti-allergic active compounds is especially important

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