Three-dimensional microfluidic chip and method for improving cell purity magnetic separation
A microfluidic chip and magnetic separation technology, applied in stress-stimulated microbial growth methods, biochemical equipment and methods, treatment of microorganisms with electricity/wave energy, etc., can solve the problem of low separation purity and achieve low price , The manufacturing process is simple, and the effect of ensuring high-purity recovery
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Embodiment 1
[0073] This embodiment relates to a three-dimensional microfluidic chip for improving the magnetic separation of cell purity, such as figure 1 As shown, the connected inlet unit, horizontal magnetic separation unit, vertical magnetic separation unit and outlet unit.
[0074] The inlet unit includes three inlets, namely cell suspension inlet 1, primary buffer inlet 2 and second buffer inlet 3. The first buffer inlet 2 and the second buffer inlet 3 constitute the first buffer inlet 2 and the second buffer inlet 3 respectively.
[0075] The transverse magnetic separation unit is composed of a transverse magnetic separation microflow channel 11 , a microstructure with a local enhanced magnetic field gradient and a first magnet 9 . The immunomagnetic bead-labeled cell mixture and the buffer solution are respectively injected from the cell suspension inlet 1 and the first buffer inlet 2, and when flowing through the transverse magnetic separation microchannel 11, the magnetic field...
Embodiment 2
[0096] This embodiment relates to a three-dimensional microfluidic chip for improving the magnetic separation of cell purity, which is a variation example of embodiment 1, the difference is that in embodiment 2, the shape of the inlet of the inlet unit is square, and the sides The length is 1 mm; the shape of the inlet of the outlet unit is square, and the side length is 1 mm; the material of the soft magnetic local magnetic field enhancement structure 8 is iron-nickel alloy, and the shape is a cuboid single-sided comb structure. The soft magnetic local magnetic field enhancement structure has 8 serrations, that is, the magnetic conduction length L6 is 4 mm, the width W5 is 600 μm, and the bottom wall thickness W4 of the groove is 150 μm. The axial free end of the soft magnetic field gradient locally enhanced microstructure and the groove The distance L7 between the bottom ends is 2mm. The first stage magnet 9 and the second stage magnet 10 are square electromagnets, and the s...
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