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Novel application of pyrroloquinoline quinone in preventing and/or treating male reproductive dysfunction

A technology of pyrroloquinoline quinone and male reproduction, which is applied in the field of medicine, can solve problems such as unsatisfactory effects, lack of spermatogenesis and sperm quality treatment drugs, and achieve high application value effects

Active Publication Date: 2017-09-19
NANJING MEDICAL UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs commonly used clinically include nucleotide and amino acid preparations and hormone drugs, but the effect is not satisfactory, and there is a lack of more effective therapeutic drugs for improving spermatogenesis and sperm quality

Method used

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  • Novel application of pyrroloquinoline quinone in preventing and/or treating male reproductive dysfunction
  • Novel application of pyrroloquinoline quinone in preventing and/or treating male reproductive dysfunction
  • Novel application of pyrroloquinoline quinone in preventing and/or treating male reproductive dysfunction

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Experimental program
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Embodiment

[0026] Experimental Animal Feeding, Breeding and Identification

[0027] All experimental mice in the research of the present invention were raised by the SPF level experimental animal center of Nanjing Medical University.

[0028] In this study, Bmi-1 knockout heterozygous mice (Bmi1 + / - ) (129Ola / FVB / N hybrid background) (gifted by Professor Anton Berns of the Netherlands Institute of Oncology) for mating cages of male and female pairs to obtain wild-type (WT) and Bmi1 homozygous (Bmi1 - / - ) mice. Take Bmi1 + / - DNA was extracted from the tails of offspring mice, amplified with Bmi1-specific primers, and genotyped by gel electrophoresis to obtain homozygous male mice required for the experiment.

[0029] Animal experiments strictly followed the animal experiment management regulations of Nanjing Medical University and were reviewed by the Animal Experiment Ethics Committee.

[0030] drug treatment

[0031] 3-week-old Bmi1 - / -The mice were randomly divided into a normal ...

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Abstract

The invention discloses application of pyrroloquinoline quinone (PQQ) in preparing products for preventing and / or treating male reproductive dysfunction or improving male reproductive function. Research results of the invention show that the pyrroloquinoline quinone can obviously reduce Bmi1- / -mouse spermatogenic cell DNA damage and finally can improve Bmi1- / -mouse spermatogenic cell proliferation and inhibit spermatogenic cell apoptosis. According to the novel application disclosed by the invention, the pyrroloquinoline quinone is applied to treat male sterility for the first time, a more ideal treating effect is obtained, a novel preventing and treating choice is provided for treating male sterility in clinical application, and very high application valve is achieved.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the use of pyrroloquinoline quinone or a salt thereof in the preparation of products for preventing and / or treating male reproductive dysfunction or improving male reproductive function. Background technique [0002] According to statistics, around the world, about 15% of all couples of childbearing age have infertility problems, and about half of them are male factors. Clinically, male infertility is mainly divided into azoospermia, oligospermia, asthenospermia, and sperm deformity. At present, the drugs commonly used clinically include nucleotide and amino acid preparations and hormone drugs, but the effect is not satisfactory, and there is a lack of more effective therapeutic drugs for improving spermatogenesis and sperm quality. [0003] The chemical name of pyrroloquinoline quinone (PQQ) is 4,5-dihydro-4,5-dioxide-1-hydropyrrole (2,3f)quinone-2,7,9-tricarboxylic acid (for...

Claims

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Application Information

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IPC IPC(8): A61K31/4745A61P15/08
CPCA61K31/4745
Inventor 苗登顺戴秀亮孙伟伟王晖
Owner NANJING MEDICAL UNIV
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