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Method for preparing cnidium lactone from plant and application thereof in preparation of cosmetics

A technology of osthole and plants, which is applied in the application field of preparing cosmetics, can solve the problems that the product yield is greatly affected and the number of recrystallizations is large, and achieves the advantages of convenient product quality control, convenient operation, and simple process flow Effect

Active Publication Date: 2017-09-15
GUANGZHOU GIALEN COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also as the invention patent CN 201010527673.4 discloses "a method for extracting osthole from the Chinese medicine Cnidium Fructus", although the process method is simple, it is also suitable for large-scale industrial production; but in the process method, the concentration is greater than 90%. Ethanol solution carries out crystallization and recrystallization, because 90% ethanol solution is all very strong to the dissolubility of osthole and impurity, so not only need the times of recrystallization many times, but also bigger influence on the yield of product
The method for extracting and separating osthole of the present invention can overcome the above-mentioned disadvantages, and the method is adopted for production, with high yield, simple operation, low energy consumption, and easy realization of industrial scale-up, which has not been reported yet.

Method used

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  • Method for preparing cnidium lactone from plant and application thereof in preparation of cosmetics
  • Method for preparing cnidium lactone from plant and application thereof in preparation of cosmetics
  • Method for preparing cnidium lactone from plant and application thereof in preparation of cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Extraction of osthole from the fruit of the plant Cnidium monnieric (L.) Cusson.

[0056] (1) Extraction of osthole

[0057] The fruit of the plant Cnidium monnieric (L.) Cusson. is used as a raw material, which is cleaned, dried, and crushed into a coarse powder of about 20 meshes. Get 1000g of Fructus Cnidii coarse powder, add 10 times the amount (10L) of ethanol aqueous solution with a concentration of 85% by volume, fully stir and mix, heat to 80°C for reflux extraction for 2 hours, filter, and the filtrate is for use; Double the amount (8L) of 85% (v / v) ethanol aqueous solution, stir and mix well, heat to 80°C for reflux extraction for 1.5 hours, filter, and the filtrate is set aside; continue to add 8 times the amount (8L) of 85% (v / v) to the filter residue / v) Ethanol aqueous solution, fully stirred and mixed, heated to 80° C. for reflux extraction for 1.5 hours, filtered, and the filtrate was combined with the previous two filtrates to obtain an extract of osth...

Embodiment 2

[0065] Preparation of osthole from the fruit of Cnidium formosanum YABE

[0066] (1) Extraction of osthole

[0067] The fruit of the plant Cnidium formosanum YABE is used as a raw material, which is cleaned, dried, and crushed into a coarse powder of about 18 meshes. Take 1000g of Fructus Cnidii coarse powder, add 10 times the amount (10L) of 85% (v / v) ethanol aqueous solution, stir and mix well, heat to 80°C for reflux extraction for 2 hours, filter, and the filtrate is set aside; continue to add 8 times of the filter residue Amount (8L) of 85% (v / v) ethanol aqueous solution, stir and mix well, heat to 80°C for reflux extraction for 1.5 hours, filter, and the filtrate is set aside; continue to add 8 times the amount (8L) of 85% (v / v) to the filter residue v) Ethanol aqueous solution, fully stirred and mixed, heated to 80° C. for reflux extraction for 1.5 hours, filtered, and the filtrate was combined with the previous two filtrates to obtain an extract of osthole, which was ...

Embodiment 3

[0075] Preparation of osthole II from the fruit of the plant Cnidium monnieric (L.) Cusson.

[0076] (1) Extraction of osthole

[0077] The fruit of the plant Cnidium monnieric (L.) Cusson. is used as a raw material, which is cleaned, dried, and crushed into a coarse powder of about 15 meshes. Take 1000g of Cnidium Fructus Cnidii coarse powder, add 10 times the amount (10L) of 90% (v / v) ethanol aqueous solution, fully stir and mix, heat to 60°C for ultrasonic (250Hz) extraction for 1.5 hours, filter, and the filtrate is set aside; the filter residue continues to Add 8 times the amount (8L) of 90% (v / v) ethanol aqueous solution, stir and mix well, heat to 60°C and ultrasonically (250Hz) extract for 1.0 hour, filter, and the filtrate is set aside; continue to add 8 times the amount (8L) of the filter residue 90% (v / v) aqueous ethanol solution, fully stirred and mixed, heated to 60°C for ultrasonic (250Hz) extraction for 1.0 hour, filtered, and the filtrate was combined with the...

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Abstract

The invention discloses a method for preparing cnidium lactone from plant and an application thereof in the preparation of cosmetics. The method first pretreats plant fruits containing cnidium lactone, and steps, such as ethanol extraction, liquid-residue separation, crude cnidium lactone precipitation, accurate-concentration ethanol crystallization and recrystallization, are then carried out, and thereby the active ingredient of cnidium lactone monomer is obtained. Not only can the method provided by the invention effectively remove impurities, the transfer rate of cnidium lactone is high. The obtained ingredient has functions such as inhibiting bacteria and resisting inflammation, killing parasites to relieve itching, resisting allergy, relieving spasm and decreasing pressure, resisting arrhythmia and enhancing immunity, and the ingredient can be prepared into emulsion systems and surfactant systems as cosmetic and skin-care products with the effects of resisting allergy, killing parasites to relieve itching, inhibiting bacteria and resisting inflammation, eliminating acnes and the like.

Description

technical field [0001] The invention belongs to the field of medicine and cosmetics, in particular to a method for preparing osthole from plants and its application in preparing cosmetics. Background technique [0002] Osthole, also known as methoxyparscreol, or parsley phenol methyl ether, or Osthole (Ost), is mainly found in Umbelliferae and Rutaceae plants, and is the Umbelliferae plant Cnidium monnieri (L.) Cuss. or Cnidiumformosanum YABE The main active ingredient in the dried ripe fruit, its chemical name is 7-methoxy-8-prenyl coumarin (7-methoxy-8-[3-methylpent- 2-eny1] coumarin), is a kind of hydrocarbyl coumarin active chemical composition with the highest content in Fructus Cnidii, is colorless columnar crystal, molecular formula: C 15 h 16 o 3 , the relative molecular mass is 244.29, and the melting point is 82-84°C. Pharmacological experiments on osthole show that osthole has antihypertensive, antiarrhythmic, anti-aging, anti-tumor, anti-osteoporosis, anti-in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/16A61K8/49A61Q19/00A61Q17/00A61K31/37A61P31/04A61P17/10A61P37/08A61P29/00
CPCA61K8/498A61Q17/005A61Q19/00C07D311/16
Inventor 李吉来傅国华刘少勇郑泽苗赵家禾刘文丽
Owner GUANGZHOU GIALEN COSMETICS
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