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Preparation method of Cu<2+>-chelated hydroxypropyl polymethacrylate supermacroporous crystal gel medium

A polyhydroxypropyl methacrylate, ultra-large technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of low adsorption capacity, complicated preparation process, small specific surface area, etc., and achieve large specific surface area and thermal stability The effect of good performance and convenient operation process

Active Publication Date: 2017-09-08
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the disadvantages that the existing crystal gel medium cannot be stored at room temperature, has small specific surface area, complicated preparation process and low adsorption capacity; the present invention provides a Cu 2+ Preparation method of chelated polyhydroxypropyl methacrylate super-macroporous crystal gel medium

Method used

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  • Preparation method of Cu&lt;2+&gt;-chelated hydroxypropyl polymethacrylate supermacroporous crystal gel medium
  • Preparation method of Cu&lt;2+&gt;-chelated hydroxypropyl polymethacrylate supermacroporous crystal gel medium
  • Preparation method of Cu&lt;2+&gt;-chelated hydroxypropyl polymethacrylate supermacroporous crystal gel medium

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Embodiment 1

[0055] a Cu 2+ The preparation method of chelated polyhydroxypropyl methacrylate super-macroporous crystal gel medium comprises the steps as follows:

[0056] (1) Preparation of polyhydroxypropyl methacrylate super-macroporous crystal gel medium:

[0057] Dissolve 1.3mL monomer hydroxypropyl methacrylate and ligand material glycidyl methacrylate 0.1mL in 5mL deionized water, and dissolve 0.283g cross-linking agent N'N-methylenebisacrylamide (MBAAm) in 10mL of deionized water, after completely dissolved, mixed to form a solution with a volume fraction of about 10.9%; filled with nitrogen for 20min, under the premise of nitrogen protection, added initiator APS 0.02g, ice-bathed for 30min, and then quickly added catalyst TEMED 25μL, After stirring, quickly transfer it to a syringe (5mL, id=1.3cm), lower the temperature in a constant temperature tank at 0.15°C / min and react at a constant temperature of -16°C for 24h; after the reaction, dissolve at 25°C for 16h, deionize Washing...

Embodiment 2

[0067] a Cu 2+ The preparation method of chelated polyhydroxypropyl methacrylate super-macroporous crystal gel medium comprises the steps as follows:

[0068] (1) Preparation of polyhydroxypropyl methacrylate super-macroporous crystal gel medium:

[0069]Dissolve 1.3 mL of monomer hydroxypropyl methacrylate and 0.1 mL of ligand material glycidyl methacrylate in 5 mL of deionized water, and dissolve 0.1 g of cross-linking agent N'N-methylenebisacrylamide (MBAAm) in 10mL of deionized water, after completely dissolved, mixed to form a solution with a volume fraction of about 9.8%; filled with nitrogen for 20 minutes, under the premise of nitrogen protection, added initiator APS 0.02g, ice-bathed for 10 minutes, and then quickly added catalyst TEMED 25μL, After stirring, quickly transfer it to a syringe (5mL, id=1.3cm), lower the temperature in a constant temperature tank at 0.5°C / min and react at a constant temperature of -20°C for 16h; after the reaction, dissolve at 20°C for 2...

Embodiment 3

[0091] a Cu 2+ The preparation method of chelated polyhydroxypropyl methacrylate super-macroporous crystal gel medium comprises the steps as follows:

[0092] (1) Preparation of polyhydroxypropyl methacrylate super-macroporous crystal gel medium:

[0093] Dissolve 1.3mL monomer hydroxypropyl methacrylate and ligand material glycidyl methacrylate 0.15mL in 8mL deionized water, and dissolve 0.07g cross-linking agent N'N-methylenebisacrylamide (MBAAm) in 10mL of deionized water, after completely dissolved, mixed to form a solution with a volume fraction of about 8%; filled with nitrogen for 20min, under the premise of nitrogen protection, added 0.02g of initiator APS, ice bathed for 10min, and then quickly added catalyst TEMED 25μL, After stirring, quickly transfer it to a syringe (5mL, id=1.3cm), cool down at 0.15°C / min in a constant temperature tank and react at a constant temperature of -18°C for 30h; after the reaction, dissolve at 27°C for 20h, deionize After washing with ...

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Abstract

The invention relates to a preparation method of a Cu<2+>-chelated hydroxypropyl polymethacrylate supermacroporous crystal gel medium. The preparation method comprises the following steps: (1) preparing a hydroxypropyl polymethacrylate supermacroporous crystal gel medium; and (2) preparing the Cu<2+>-chelated hydroxypropyl polymethacrylate supermacroporous crystal gel medium. The Cu<2+>-chelated hydroxypropyl polymethacrylate supermacroporous crystal gel medium is prepared by carrying out free radical polymerization at a low temperature by taking water as a pore-forming agent and is environment-friendly, sanitary and easy to store, the operation process is convenient, and subsequent procedures are simple; the crystal gel medium has super-large pores which have the sizes of 5-100 microns and are mutually communicated, and the porosity is large and reaches 75%; the crystal gel medium has a large specific surface area and capable of effectively adsorbing biological macromolecules; the crystal gel medium has good water absorbing property and can absorb water to expand within 1-2 seconds after being extracted, and the water absorption capacity reaches 10.2g (water) / g (crystal gel medium); and the crystal gel medium has good reusability and good thermal stability and further has wide application prospects in the separation of biological macromolecules.

Description

technical field [0001] The present invention relates to a Cu 2+ The invention discloses a method for preparing a chelating polyhydroxypropyl methacrylate super-macroporous continuous bed crystal gel medium, which belongs to the technical field of bioseparation and medicine. Background technique [0002] Crystal gel medium is a polymer material formed by polymerization or cross-linking of monomers or polymer precursors under suitable freezing conditions. Its high porosity, high mechanical properties and chemical stability make it suitable for various types of molecular separation and The purification aspect becomes quite attractive as a material choice. Its particularity is that it is a monolithic continuous bed medium, which is different from the gel obtained by conventional continuous bed and conventional reaction polymerization in its skeleton and pore structure. Crystal colloid medium has ultra-large pores with a size ranging from several microns to hundreds of microns ...

Claims

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Application Information

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IPC IPC(8): C08F220/28C08F220/32C08F222/38C08F8/30C08F8/42C08J9/28B01J20/26B01J20/30
CPCB01J20/261B01J20/265C08F8/30C08F8/42C08F220/28C08F220/281C08F2810/50C08J9/286C08J2333/10C08F220/325C08F222/385
Inventor 马烽翟孟凡李俊英万斌彬
Owner QILU UNIV OF TECH
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