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Method for effectively recovering varicocele serum sex hormone level by using morinda officinalis polysaccharide extract to stimulate GnRH (gonadotropin-releasing hormone) release

A technology of varicocele and Morinda officinalis polysaccharide, which is applied in the direction of drug combination, cardiovascular system diseases, endocrine system diseases, etc., to achieve the effect of promoting GnRH synthesis and repairing GnRH synthesis and secretion ability

Inactive Publication Date: 2017-09-08
FUJIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Morinda officinalis is often used in clinical Chinese medicine compound to treat male diseases such as impotence and oligospermia. At present, there is no research to confirm the effect and mechanism of Morinda officinalis polysaccharides on maintaining the balance of hormones in the hypothalamus-pituitary-testosterone axis

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  • Method for effectively recovering varicocele serum sex hormone level by using morinda officinalis polysaccharide extract to stimulate GnRH (gonadotropin-releasing hormone) release
  • Method for effectively recovering varicocele serum sex hormone level by using morinda officinalis polysaccharide extract to stimulate GnRH (gonadotropin-releasing hormone) release
  • Method for effectively recovering varicocele serum sex hormone level by using morinda officinalis polysaccharide extract to stimulate GnRH (gonadotropin-releasing hormone) release

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Embodiment 1

[0021] Example 1: Animal grouping and administration method:

[0022] Seventy male SD rats were randomly divided into 7 groups according to their body weight and random numbers, each with 10 rats, namely the sham operation group (SO), the experimental varicocele model group (VC), and the solvent control group. 25mg / kg Morinda officinalis crude polysaccharide treatment group (M25 group), 50mg / kg Morinda officinalis crude polysaccharide treatment group (M50 group), 100mg / kg Morinda officinalis crude polysaccharide treatment group (M100 group), 200mg / kg Morinda officinalis Day crude polysaccharide treatment group (M200 group). Except for the sham operation group, experimental varicocele surgery was performed. The animals were kept in single cages and rested for 3 days.

[0023] On the 4th day after operation, the experimental animals were treated with Morinda officinalis crude polysaccharide liquid. Animals in the sham operation group and varicose group were not administered; the a...

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Abstract

The invention discloses a method for effectively recovering a varicocele serum sex hormone level by using a morinda officinalis polysaccharide extract to stimulate GnRH (gonadotropin-releasing hormone) release. The method comprises the following steps of (1) establishing an experimental varicocele animal model, (2) performing morinda officinalis crude polysaccharide treatment in an early stage, observing morphologic change of a hypothalamus Arc neuron, GnRH distribution and content change, and discussing a function and a mechanism of morinda officinalis crude polysaccharide for recovering body related hormone incretion by restoring a GnRH neuron, and (3) allowing a result to indicate that 50-100mg / kg morinda officinalis crude polysaccharide can effectively restore synthesis and secretion capacity of early-stage experimental varicocele hypothalamus GnRH. The morinda officinalis crude polysaccharide can restore reduction of the varicocele serum sex hormone level by stimulating secretion of the hypothalamus GnRH, and is crucial to maintaining and restoring of hypophysis and testicle functions.

Description

Technical field [0001] The present invention relates to the technical field of restoring varicocele serum sex hormone levels, in particular to a method for Morinda officinalis polysaccharide extract to effectively restore the varicocele serum sex hormone levels by stimulating GnRH release. Background technique [0002] Varicocele refers to the vascular disease caused by the expansion and tortuosity of the spermatic vein and the variegated venous plexus. It usually occurs on the left side (85%-90%), and leads to bilateral testicular pathological damage and spermatogenesis (57 %–85.7%). Varicocele may cause seminiferous epithelial degeneration and increased spermatogenic cell apoptosis through mechanisms such as increased testicular temperature, hypoperfusion, hypoxia, oxidative stress, and adrenal metabolite reflux, but its specific etiology is currently unclear . At present, varicocele has become a known main cause of male infertility, which seriously threatens male reproductiv...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P5/02A61P9/14
Inventor 王玮朱珠赵小贞
Owner FUJIAN MEDICAL UNIV
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