Lycium ruthenicum extract micro-capsule and lycium ruthenicum preparations prepared from same
A technology of Lycium barbarum extract and Lycium nigra, applied in microcapsules, antidote, pill delivery and other directions, can solve the problems such as staying in the research stage of small or pilot test, inconvenient production, transportation and storage, and difficulty in transforming enterprise achievements. , to achieve the effects of enhancing human immunity, high microencapsulation efficiency, and easy industrial production.
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Embodiment 1
[0030] 1. Preparation of black fruit wolfberry extract: take quantitative black fruit wolfberry fruit, put it in a suitable extraction tank, add water to immerse the medicinal material, the material-liquid ratio is 1:20, soak for 1 hour, heat to 85°C, keep for 45 minutes, separate and extract Liquid and medicinal dregs were extracted 3 times according to the law, and the extracts were combined and concentrated in a rotary evaporator until the relative density of the extract was 1.35.
[0031] 2. Preparation of microcapsules by spray drying method: weigh a certain amount of gelatin, dissolve it with 90% ethanol to make the concentration 2%, mix the wolfberry extract and capsule material solution into a spray liquid in a ratio of 1:3, stir evenly, adjust Spray drying parameters, injection speed (6ml / min), inlet air temperature (130 ℃), fan speed (1400 rpm), atomization pressure (1.5 MPa), spray drying microencapsulation treatment, collected after microencapsulation Lycium barbar...
Embodiment 2
[0034]1. Preparation of black fruit wolfberry extract: take quantitative black fruit wolfberry fruit, put it in a suitable extraction tank, add water to immerse the medicinal materials, the ratio of material to liquid is 1:30, soak for 1.5h, heat to 88°C, keep for 50min, and separate The extract and dregs are extracted 3 times according to the law, and the extracts are combined and concentrated in a rotary evaporator until the relative density of the extract is 1.25.
[0035] 2. Preparation of microcapsules by spray condensation method: disperse the dry powder of Lycium barbarum extract in heated and melted glyceryl monostearate, make a spray liquid at a ratio of 1:2, and carry out spray condensation. The adjustment parameters are: sample injection speed (6 ml / min), freezing temperature (-30°C), fan speed (1800 rpm), and atomization pressure (0.2 MPa), to solidify glyceryl monostearate to form wolfberry extract microcapsules.
[0036] 3. Preparation of black fruit wolfberry gr...
Embodiment 3
[0046] 1. Preparation of Lycium barbarum extract: Take a certain amount of Lycium barbarum fruit, put it in a suitable extraction tank, add water to immerse the medicinal material, the ratio of material to liquid is 1:25, soak for 1.2 h, heat to 90°C, and keep for 55 min. Separate the extract, extract the dregs three times according to the law, combine the extracts, put them in a rotary evaporator and concentrate until the relative density of the extract is 1.3.
[0047] 2. Preparation of microcapsules by spray-drying method: Weigh a certain amount of PLGA, dissolve it with 88% ethanol to make the concentration 3%, make a spray solution of wolfberry extract and capsule material solution in a ratio of 1:3, stir evenly, adjust The parameters of spray drying were as follows: injection speed (8mL / min), inlet air temperature (140 ℃), fan speed (1500 rpm), and atomization pressure (0.5 MPa) to prepare microcapsules.
[0048] 3. Dry granulation and tabletting:
[0049] (1) Mix the m...
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