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N-(2-Thienyl)methylene-2-cyano-3-heterocyclic acrylhydrazine derivative and application thereof

A technology of alkyl and compound, which is applied in the field of heterocyclic Schiff base compounds, can solve the problems of the use of heterocyclic Schiff base compounds as antioxidants and agricultural pesticides, and achieve excellent antioxidant performance and novel structure Effect

Active Publication Date: 2017-08-29
启东市环球齿轮有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report on the use of heterocyclic Schiff base compounds as antioxidants and agricultural pesticides

Method used

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  • N-(2-Thienyl)methylene-2-cyano-3-heterocyclic acrylhydrazine derivative and application thereof
  • N-(2-Thienyl)methylene-2-cyano-3-heterocyclic acrylhydrazine derivative and application thereof
  • N-(2-Thienyl)methylene-2-cyano-3-heterocyclic acrylhydrazine derivative and application thereof

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Experimental program
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Effect test

Embodiment 1

[0036] The synthesis of embodiment 1 compound 1~9

[0037] Synthesis principle:

[0038]

[0039] 1. Synthesis of compound 1

[0040] (1) Synthesis of intermediates

[0041] Put 0.01mol of cyanoacetylhydrazide in a three-necked flask, add 15mL of dichloromethane as a solvent, 3mL of acetic acid as a catalyst, and stir at room temperature. Take 0.01mol of thiophene-2-carboxaldehyde and add it to 5mL of dichloromethane. After fully dissolving, add it dropwise into a three-necked flask with a constant pressure dropping funnel, react for 5 hours, and detect the end point with a thin-layer silica gel plate (TLC). The reaction solution was placed in a beaker and washed repeatedly with distilled water until neutral. Liquid separation and vacuum distillation, suction filtration and drying to obtain the intermediate.

[0042] (2) Synthesis of the target compound

[0043] Take 0.01 mol of the intermediate and place it in a three-neck flask, add 15 mL of absolute ethanol as a sol...

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Abstract

The invention relates to heterocyclic Schiff base compounds and their application, in particular to N-(2-thienyl)methylene-2-cyano-3-heterocyclic acrylhydrazine derivative and application thereof. The technical problem to be solved herein is to provide a heterocyclic Schiff base compound capable of serving as an antioxidant and agricultural pesticide, and the structural formula of the compound is shown as in formula I that is shown in the description. A heterocyclic compound is introduced to Schiff base compounds according to the splicing principle of bioactive groups, active compounds or active pilot compounds having novel structure and good activity are discovered, and good basis is laid for the creation of novel antioxidants and pesticides.

Description

technical field [0001] The invention relates to heterocyclic Schiff base compounds and applications thereof, in particular to N-(2-thienyl)methylene-2-cyano-3-heterocyclic acrylohydrazide derivatives and applications thereof. Background technique [0002] Antioxidants can effectively delay or inhibit the oxidative deterioration of many substances, especially sugar, fat, protein, nucleic acid and other biological macromolecules, and are widely used in many fields: (1) In food processing, antioxidants can inhibit Oil oxidation to prevent rancidity, often used as food antioxidant additives; (2) In the field of life science and medicine, antioxidants can remove free radicals in the body, slow down the formation of the body's peroxidation state, and prevent and treat various diseases caused by free radicals , improve the body's immunity, thereby protecting human health; (3) In the field of chemical industry, antioxidants are used as stability additives for chemical products to im...

Claims

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Application Information

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IPC IPC(8): C07D409/12C07D333/24C07D333/28A61P39/06A01N43/10A01N43/40A01P7/02A01P7/04
CPCA01N43/08A01N43/10A01N43/40C07D307/54C07D333/24C07D333/28C07D405/12C07D409/12C09K15/22C09K15/28
Inventor 徐志宏杨建岳媛严映坤刘辉高扬唐孝荣
Owner 启东市环球齿轮有限公司
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