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Bacterial cellulose-chitosan-laponite compound wound dressing and preparation method thereof

A technology of bacterial cellulose and wound dressing, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of ineffective prevention of wound fat liquefaction, poor moisture absorption and breathability, and low smoothness of wound surface, so as to promote growth, differentiation and epithelial Cell crawling, avoiding secondary damage, and reducing the effect of infection

Active Publication Date: 2017-08-22
湖北中创医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the moisture absorption and ventilation effect of the composite film is still poor, and it cannot effectively prevent the liquefaction of wound fat, and the smoothness of the wound surface after healing is low.

Method used

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  • Bacterial cellulose-chitosan-laponite compound wound dressing and preparation method thereof

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preparation example Construction

[0029] Found through a large number of experiments by the inventor, the preferred preparation method of the bacterial cellulose-chitosan-lithium compound wound dressing comprises the following steps:

[0030] S1. Soak the bacterial cellulose in pure water, change the pure water 1-3 times during the period, then take it out and dry it at 37-45°C;

[0031] S2. preparing an aqueous acetic acid solution, adding the chitosan and sodium carboxymethyl cellulose, dissolving and mixing; soaking the bacterial cellulose treated in step S1 in the above solution, stirring to reach equilibrium, and freeze-drying;

[0032] S3. prepare lithium alginate aqueous solution, add sodium pyrophosphate, mix and add the product of step S2, soak, stir to reach equilibrium, and freeze-dry to obtain the bacterial cellulose-chitosan-lithium diatomite composite wound dressing.

[0033] Bacterial cellulose-chitosan-lectorite composite wound dressing of the present invention is prepared according to the abov...

Embodiment 1

[0037] A bacterial cellulose-chitosan-lithium composite wound dressing, which is formed by sequential crosslinking of chitosan and lithium celite on the bacterial cellulose; the quality of the bacterial cellulose, chitosan, and lithium The ratio is 6:2:15.

[0038] The preparation method of above-mentioned compound wound dressing, comprises the steps:

[0039] S1. Soak bacterial cellulose in a large amount of pure water for 4 hours, replace the pure water twice during the period, then take it out and dry it in an oven at 40°C for 12 hours;

[0040] S2. Prepare 100ml of 2% acetic acid aqueous solution, add 2g chitosan and 0.8g sodium carboxymethylcellulose, dissolve and mix; soak 6g of the bacterial cellulose treated in step S1 in the above solution, and stir for 3h Equilibrium, freeze-dried;

[0041] S3. The preparation concentration is 100ml of 15% lithium aqueous solution, add 0.5g sodium pyrophosphate, add the product of step S2 after mixing, soak, stir for 3h to reach eq...

Embodiment 2

[0044] The present embodiment is substantially the same as Example 1, and the bacterial cellulose is 6g. The difference is that the mass ratio of the bacterial cellulose, chitosan, and lithium diatomaceous earth is 6:3:12, and the shell in the acetic acid aqueous solution The mass fraction of polysaccharide is 3%, and the mass ratio of chitosan and sodium carboxymethyl cellulose is 5:2; The mass ratio is 30:1.

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Abstract

The invention discloses a bacterial cellulose-chitosan-laponite compound wound dressing. The dressing is formed by sequentially crosslinking chitosan and laponite to bacterial cellulose, wherein the mass ratio of bacterial cellulose to chitosan to laponite is 6:1.5-3:12-18. Raw materials are easy to obtain, the preparation technology is simple, bacterial cellulose, chitosan and lapnonite are compounded to form a three-dimensional nanofiber mesh through a physical crosslinking method, during clinic use of the dressing, a wound surface is covered with a macromolecule nanometer layer of a breathable net structure, an ideal healing environment is formed, cell caryomitosis can be accelerated, the wound is kept wet locally, no dry scab is formed, pain is reduced, meanwhile, the infection probability is lowered, the product bacterium obstruction and moisturizing effect is brought into full play, and the mechanical performance and the water retention breathability of the compounded bacterial cellulose can be further improved. The dressing can effectively increase the wound healing speed, and the effect of nursing chronic wounds hard to heal or burn and scald wounds is remarkable.

Description

technical field [0001] The invention belongs to the technical field of medical composite wound dressings, and more specifically relates to a bacterial cellulose-chitosan-lithium diatomaceous earth composite wound dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, and it is also an important guarantee for maintaining the balance and stability of the human body environment. It plays a protective role in the human body, including regulating body temperature and resisting foreign bacteria. However, skin injuries are unavoidable in daily life, such as skin damage caused by various external factors, which can cause problems such as metabolism, endocrine and immune dysfunction. [0003] Wounds can be divided into acute wounds and chronic wounds according to time, and can be divided into superficial wounds and full-thickness wounds according to the depth of the skin involved in the injury. The reasons for delaye...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/40A61L15/44
CPCA61L15/18A61L15/28A61L15/40A61L15/44A61L2300/232A61L2300/404A61L2300/412C08L5/08C08L1/02
Inventor 张雨成宋炜韩振伟冯世忠张磊戴琦
Owner 湖北中创医疗用品有限公司
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