Cosmetic preparation prepared from human umbilical cord mesenchymal stem cell-derived exosomes

A technology of stem cells and exosomes, applied in the field of biomedicine, can solve problems such as unsatisfactory anti-aging effects, achieve large market prospects and application value, low preparation cost, and simple production methods

Inactive Publication Date: 2017-08-22
深圳市赛欧细胞技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, it has a broad market prospect in repairing aging skin / damaged skin, but the anti-aging effect of products in this field is not satisfactory at present, and finding a good anti-aging product is an urgent matter in this field at present

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 This example discloses a cosmetic preparation of exosomes derived from human umbilical cord mesenchymal stem cells. The preparation includes the following components: freeze-dried powder of exosomes derived from human mesenchymal stem cells, glycerin, and aloe juice; three The weight ratio is 1:1:15; the aloe juice contains aloe polysaccharides with a content of 750mg / L.

[0033] The preparation method of the preparation is: weighing the freeze-dried powder of human mesenchymal stem cell-derived exosomes, glycerin, and aloe vera juice in proportion, mixing and stirring until transparent, and then filtering through microporous membranes of 0.45 μm and 0.22 μm in sequence , to obtain the cosmetic preparation.

Embodiment 2

[0034] Example 2 This example discloses a cosmetic preparation of exosomes derived from human umbilical cord mesenchymal stem cells. The preparation includes the following components: freeze-dried powder of exosomes derived from human mesenchymal stem cells, glycerin, and aloe juice; The weight ratio is 1:1:10; the aloe juice contains aloe polysaccharides, the content of which is 800mg / L.

[0035] The preparation method of the preparation is: weighing the freeze-dried powder of human mesenchymal stem cell-derived exosomes, glycerin, and aloe vera juice in proportion, mixing and stirring until transparent, and then filtering through microporous membranes of 0.45 μm and 0.22 μm in sequence , to obtain the cosmetic preparation.

Embodiment 3

[0036] Example 3 This example discloses a cosmetic preparation of exosomes derived from human umbilical cord mesenchymal stem cells. The preparation includes the following components: freeze-dried powder of exosomes derived from human mesenchymal stem cells, glycerin, and aloe juice; The weight ratio is 1:1:20; the aloe juice contains aloe polysaccharides, the content of which is 700mg / L.

[0037] The preparation method of the preparation is: weighing the freeze-dried powder of human mesenchymal stem cell-derived exosomes, glycerin, and aloe vera juice in proportion, mixing and stirring until transparent, and then filtering through microporous membranes of 0.45 μm and 0.22 μm in sequence , to obtain the cosmetic preparation.

[0038] Example 4 The method of obtaining the exosomes mentioned in Example 1 is as follows:

[0039] A. Culture and pretreatment of human MSCs

[0040] 1. Materials and reagents

[0041] 1) For MSCs from human umbilical cord, placenta, bone marrow, fa...

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PUM

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Abstract

The invention specifically relates to a cosmetic preparation prepared from human umbilical cord mesenchymal stem cell-derived exosomes, belonging to the field of biological medicine. The cosmetic preparation comprises freeze-dried powder of human umbilical cord mesenchymal stem cell-derived exosomes, glycerin and aloe juice in a weight ratio of 1: 1: 10-20. A preparation method for the cosmetic preparation comprises the following steps: weighing the human umbilical cord mesenchymal stem cell-derived exosomes, glycerin and aloe juice in proportion, then carrying out mixing under stirring until a transparent mixture is obtained, and subjecting the mixture to filtering with a 0.45-[mu]m microfiltration membrane and then to filtering with a 0.22-[mu]m microfiltration membrane so as to obtain the cosmetic preparation. According to the invention, the novel human umbilical cord mesenchymal stem cell-derived exosomes are used as an active component for preparation of the cosmetic preparation with obvious effect; and the cosmetic preparation can overcome the problem of skin aging of people and has good market prospects and application value.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a cosmetic preparation of exosomes derived from human umbilical cord mesenchymal stem cells. Background technique [0002] In 2013, three scientists from the United States and Germany won the Nobel Prize in Physiology or Medicine for their discovery of the regulation mechanism of cell vesicle transport. Exosomes, as an important class of vesicles in the human body, have also begun to receive more and more attention. Scientists have found that exosomes are involved in important biological processes such as immune response, apoptosis, angiogenesis, inflammation, and coagulation. Cells secrete some signaling molecules to distant tissues or cells by secreting exosomes. in order to play a regulatory role. [0003] In 2016, Xu Wenrong and others from Jiangsu University School of Medicine in China found that the proteins contained in exosomes derived from human umbilical cord me...

Claims

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Application Information

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IPC IPC(8): A61K35/51A61K36/886A61K36/896A61K8/99A61K8/9794A61K8/34A61Q19/08A61P17/18
Inventor 钱开诚张涤平刘家权鲁立聂燕华陈贤光梅杰
Owner 深圳市赛欧细胞技术有限公司
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