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Novel method for preparing calamine and nitrofurazone pharmaceutical composition

A technology of nitrofurazone and calamine is applied in directions such as drug combination, drug delivery, and pharmaceutical formulation, which can solve the problems of inconvenient operation and control, easy moisture absorption of medicinal powder, easy generation of dust, etc. The effect of drug efficacy and prolongation of stratification time

Inactive Publication Date: 2017-08-04
BEIJING SHOUER PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the powder needs to be dry-grinded. The grinding process is easy to generate dust, and the powder is easy to absorb moisture and agglomerate, which is not easy to operate and control.

Method used

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  • Novel method for preparing calamine and nitrofurazone pharmaceutical composition
  • Novel method for preparing calamine and nitrofurazone pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The raw and auxiliary materials are composed of:

[0038] Material name Dosage (unit: kg) Calamine 12.0kg Zinc oxide 12.0kg Furacilin 30g Sodium carboxymethyl cellulose 375g glycerin 7500ml purified water Add to a total of 150,000ml

[0039] Preparation:

[0040] (1) Put sodium carboxymethyl cellulose into an appropriate amount of purified water, and when it meets water to form a group, use a stir bar to disperse the "big group" into small pieces;

[0041] (2) Add nitrofurazone into the solution (1), stir slightly to disperse it, and avoid forming lumps;

[0042] (3) Adjust the colloid mill to the "0.01" point, add a small amount of purified water, start the colloid mill to circulate the purified water in the colloid mill, add the liquid obtained in (2) into the colloid mill, circulate for 3-5 minutes, and release;

[0043] (4) Stir the calamine powder, zinc oxide powder, glycerin, and an appropriate amount of puri...

Embodiment 2

[0047] The raw and auxiliary materials are composed of:

[0048]

[0049]

[0050] Preparation:

[0051] (1) Put sodium carboxymethyl cellulose into an appropriate amount of purified water, and when it meets water to form a group, use a stir bar to disperse the "big group" into small pieces;

[0052] (2) Add nitrofurazone to 1 / 2 amount of dispersed sodium carboxymethyl cellulose slurry, and stir slightly;

[0053] (3) Adjust the colloid mill to the "0.01" point, add a small amount of purified water, start the colloid mill to circulate the purified water in the colloid mill, add the liquid obtained in (2) into the colloid mill in stages, and circulate for 3-5 minutes each time, release;

[0054] (4) Take calamine powder and zinc oxide powder, add glycerin, 1 / 2 sodium carboxymethyl cellulose slurry and an appropriate amount of purified water to stir, and stir slightly so as not to agglomerate;

[0055] (5) Add the mixed liquid obtained in (4) to the colloid mill in stag...

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Abstract

Provide a new preparation method of calamine nitrofurazone pharmaceutical composition, especially the new preparation method of calamine nitrofurazone lotion, the raw materials of described calamine nitrofurazone lotion include calamine, zinc oxide, nitrofurazone, glycerin , sodium carboxymethylcellulose, purified water, characterized in that the method comprises first mixing nitrofurazone, at least a part of sodium carboxymethylcellulose and at least a part of water, and then mixing with the remaining components in the composition A step of. The calamine nitrofurazone lotion prepared by the new preparation method of the invention has the advantages of small sedimentation volume ratio, good uniformity, stable quality, and favorable transdermal absorption.

Description

technical field [0001] The invention relates to a new preparation method of a calamine nitrofurazone pharmaceutical composition, in particular to a new preparation method of a calamine nitrofurazone lotion. Belongs to the field of medicine. Background technique [0002] Calamine nitrofurazone lotion is a drug for dermatology. It is a preparation product of the Children's Hospital affiliated to the Seoul Institute of Children's Research. The appearance is a light pink suspension. After a long time, it precipitates and stratifies. After shaking, it becomes a homogeneous suspension. The raw and auxiliary materials used are: calamine powder, zinc oxide powder, nitrofurazone, glycerin, sodium carboxymethylcellulose and purified water. The specific composition is as follows: [0003] Material name Dosage (weight ratio) Calamine 6-10％ Zinc oxide 6-10％ Furacilin 0.014-0.020％ Sodium carboxymethyl cellulose 0.20-0.35％ glycerin 5.0-7.3％ p...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/38A61K33/30A61P17/00A61P29/00A61K31/345
CPCA61K9/10A61K9/0014A61K31/345A61K33/30A61K47/38
Inventor 马晓秋徐双节
Owner BEIJING SHOUER PHARMA FACTORY
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