Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Methods and compositions for diagnosis and prognosis of renal injury and renal failure

A technique for acute renal failure, diagnostic institute, applied in the field of diagnosing and prognosing renal injury and renal failure and composition, which can solve the problems of delayed diagnosis of AKI, inaccurate serum creatinine, etc.

Inactive Publication Date: 2017-08-01
ASTUTE MEDICAL
View PDF19 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because cellular damage in AKI can occur over a period of hours, elevated serum creatinine detected at 48 hours or more may be a late indicator of damage, and thus reliance on serum creatinine can delay the diagnosis of AKI
Furthermore, when renal function changes rapidly, serum creatinine is not a good indicator of precise renal status and need for treatment during the most acute phase of AKI

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0095] The preparation of solid phase and detectably labeled conjugates often involves the use of chemical crosslinkers. Crosslinking reagents contain at least two reactive groups, and are generally divided into homofunctional crosslinkers (containing the same reactive groups) and heterofunctional crosslinkers (containing different reactive groups). Homobifunctional crosslinkers that couple through amines, thiols, or react nonspecifically are available from a number of commercial sources. Maleimides, alkyl and aryl halides, alpha-acyl halides, and pyridyl disulfides are sulfhydryl reactive groups. Maleimides, alkyl and aryl halides, and alpha-acyl halides react with sulfhydryl groups to form sulfhydryl ether linkages, while pyridyl disulfides react with sulfhydryl groups to produce mixed sulfides. The pyridyl disulfide product is cleavable. Imidoesters are also very useful for protein-protein crosslinks. A variety of heterobifunctional crosslinkers, each combining different...

Embodiment 1

[0134] Example 1: Sample Collection of Contrast Induced Nephropathy

[0135] The purpose of this sample collection study was to collect plasma and urine samples and clinical data from patients before and after receiving intravascular contrast media. Approximately 250 adults undergoing radiographic / angiographic procedures involving intravascular administration of iodinated contrast agents were recruited. In order to enter the study, each patient must meet all of the following inclusion criteria and not meet all of the following exclusion criteria:

[0136] Inclusion criteria

[0137] Men and women aged 18 or over;

[0138] Undergoing a radiographic / angiographic procedure involving intravascular administration of a contrast agent (such as a CT scan or coronary intervention);

[0139] Hospitalization is expected for at least 48 hours after contrast administration.

[0140] Able and willing to provide written informed consent to participate in the study and follow all study p...

Embodiment 2

[0151] Example 2: Sample Collection for Cardiac Surgery

[0152] The purpose of this sample collection study was plasma and urine samples and clinical data collected from patients before and after undergoing cardiovascular surgery, a procedure known to be potentially hazardous to renal function. Approximately 900 adults undergoing this procedure were recruited. In order to enter the study, each patient must meet all of the following inclusion criteria and not meet all of the following exclusion criteria:

[0153] Inclusion criteria

[0154] Men and women aged 18 or over;

[0155] undergone cardiovascular surgery;

[0156] Toronto / Ottawa Predictive Risk Index with Renal Replacement Risk Score of at least 2 (Wijeysundera et al., JAMA 297:1801-9, 2007); and

[0157] Able and willing to provide written informed consent to participate in the study and follow all study procedures.

[0158] exclusion criteria

[0159] known pregnancy;

[0160] previous kidney transplant;

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Sensitivityaaaaaaaaaa
Login to View More

Abstract

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Interleukin-18 -binding protein as diagnostic and prognostic biomarker assays in renal injuries.

Description

[0001] This application claims the benefit of US Provisional Application 62 / 078,347, filed November 11, 2014, which is hereby incorporated by reference in its entirety. [0002] Background of the invention [0003] The following discussion of the background of the invention is provided merely to assist the reader in understanding the invention and is not an admission that it describes or constitutes prior art to the invention. [0004] The kidneys are responsible for the excretion of water and solutes from the body. Its functions include maintenance of acid-base balance, regulation of electrolyte concentration, control of blood volume, and regulation of blood pressure. Thus, loss of renal function due to injury and / or disease results in substantial morbidity and mortality. A detailed discussion of kidney injury is provided in Harrison's Principles of Internal Medicine, 17th Ed., McGraw Hill, New York, pp. 1741-1830, which is hereby incorporated by reference in its entirety. R...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N2333/7155G01N2800/347G01N33/6869G01N33/6893G01N2333/4704G01N2800/52
Inventor J·安德贝里P·麦克弗森J·格雷K·中村J·P·坎普夫
Owner ASTUTE MEDICAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com