Preparation method of N-phenyl-N-[8]quinolyl-benzamide

Abstract

The invention relates to a preparation method of N-phenyl-N-[8]quinolyl-benzamide, comprising: adding benzoyl-8-aminoquinoline, anhydrous copper acetate, triphenyl bismuth, sodium bicarbonate, 1,4-dioxane solvent and a No. 5 magneton successively into a reactor; introducing condensate into a condensing pipe from bottom to top, placing the reactor in an oil bath, and heating for reacting; after reacting, pouring reacted liquid into a liquid-diversion funnel, adding distilled water, and extracting with ethyl acetate three times; combining the obtained organic phases, rotationally drying by a rotary evaporator, and subjecting the crude product to column chromatographic separation and purification to obtain the N-phenyl-N-[8]quinolyl-benzamide; the yield is 99%. The preparation method has mild reaction conditions, the cheap metallic coper catalyst is used, no nitrogen protection is provided, oxidants for use are not required, the economy is high, and the environmental friendliness is good; the finished product is applicable to the fields of drug synthesis, pesticide synthesis, coating and dye synthesis and the like.

Description

technical field [0001] The invention relates to a preparation method for transition metal catalyzed synthesis of aromatic amide compounds, in particular to a preparation method for N-phenyl-N-[8]quinolyl-benzamide. Background technique [0002] Amide compounds are widely found in bioactive molecules, drugs and organic functional materials. Therefore, using effective methods to construct carbon-carbon bonds and carbon-heterobond bonds has become an important research direction in organic chemistry. Especially as an interdisciplinary subject composed of inorganic chemistry, organic chemistry and coordination chemistry, the application of organometallic chemistry in coordination catalysis has attracted extensive attention from chemists. [0003] As early as the 19th century, people discovered that the participation of some metal reagents in the reaction can improve the reaction efficiency, and then the transition metal catalysis gradually expanded and reached maturity, not onl...

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Problems solved by technology

With the strengthening of people's awareness of environmental protection and the current development trend of green, efficient and economical chemical reactions, the reaction conditions of this type of reaction need to be improved.

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