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A kind of preparation and adjustment method of CRRT local citrate anticoagulation replacement solution

A technology of replacement solution and citric acid, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, blood diseases, etc., can solve the problem of inaccurate, fast and convenient calculation of ion concentration of electrolyte components, inability to predict hourly change values, It is impossible to predict the degree of influence of the replacement fluid electrolyte and acid-base, so as to achieve the effect of improving the effect and optimizing the plan

Active Publication Date: 2020-01-03
GUANGDONG GENERAL HOSPITAL
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Problems solved by technology

[0008] To sum up, the main problems in the field of local citrate anticoagulation and formula adjustment of CRRT lie in the following two aspects: First, it is impossible to accurately predict the effect of sodium citrate and calcium supplementation according to CRRT treatment parameters and patient conditions. Second, it is impossible to accurately, quickly and conveniently calculate the ion concentration of various electrolyte components in each bag of replacement fluid, and it is impossible to predict the degree of influence of the replacement fluid on the electrolytes and acid-base in the patient's blood, and it is impossible to predict its hourly change value
[0009] Therefore, prior art still needs to improve and develop

Method used

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  • A kind of preparation and adjustment method of CRRT local citrate anticoagulation replacement solution
  • A kind of preparation and adjustment method of CRRT local citrate anticoagulation replacement solution
  • A kind of preparation and adjustment method of CRRT local citrate anticoagulation replacement solution

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Embodiment Construction

[0033] The specific embodiments and examples of the present invention will be described in detail below in conjunction with the accompanying drawings. The described specific embodiments are only used to explain the present invention, and are not intended to limit the specific embodiments of the present invention.

[0034] Such as figure 1 as shown, figure 1 It is the formula display table adopted in the preparation and adjustment method of CRRT local citric acid anticoagulant replacement solution of the present invention. Taking a certain heart disease patient with a body weight of 71kg as an example, 7 days after aortic dissection, the surgical site was poorly healed and oozing blood Obviously, the urine output was less (300ml / day); during CRRT treatment, the doctor ordered citrate anticoagulation, CRRT blood flow was 150ml / min, 24 hours of treatment, dehydration was 3200ml, and the replacement fluid dose was 25ml / kg / h (replacement fluid The speed is 1800ml / h), and the elect...

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Abstract

The invention discloses a preparing adjusting method of a CRRT local citric acid anticoagulation substitution fluid. The method comprises the steps of inputting a CRRT treating parameter and a biochemical and blood gas test result; adjusting the speed of citric acid in front of a pump, and controlling the target concentration of plasma citric acid at 3.5-4.0 mmol / L; according to the concentration of formula ionized calcium, and with the combination of the concentration of blood gas ionized calcium in front of a filter and the predicted input speed of 5% calcium chloride, adjusting a peripheral calcium supplement parameter; according to the concentration of blood gas bicarbonate, and with the combination of the concentration of blood gas bicarbonate in front of a filter, adjusting a peripheral sodium bicarbonate supplement parameter; according to the concentration of sodion, and with the combination of the concentration of blood gas sodion in front of a filter, adjusting a formula basic liquid injection water using amount. Therefore, not only can the speeds of sodium citrate and calcium supplement be accurately predicted in a personalized mode according to the CRRT treating parameter and the patient condition, but also the degree of influences of the substitution fluid on all electrolytes in blood and acid-base in the treating process can be predicated, and synchronous adjustment on a CRRT local citric acid anticoagulation substitution fluid formula is achieved.

Description

technical field [0001] The invention relates to the technical field of clinical continuous blood purification treatment, in particular to a method for preparing and adjusting CRRT local citrate anticoagulant replacement fluid. Background technique [0002] Continuous Renal Replacement Therapy (CRRT for short) is a long-term, continuous new blood purification technology that is performed 24 hours a day. It is currently widely used in the treatment of critically ill patients. Is one of the most common complications, it will not only affect the continuity of CRRT treatment, increase the economic burden of patients and the workload of nursing staff, but also lead to blood loss and increased blood transfusion; how to prolong the use time of CRRT extracorporeal circulation , reducing complications such as tube blockage has become a hot spot in clinical research. [0003] The use of anticoagulants is a common method to prolong the use of extracorporeal circulation in CRRT treatmen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/16A61K33/14A61P7/08A61P7/02A61K33/06A61K31/191A61K31/7004A61K33/00A61K31/194
CPCA61K31/191A61K31/194A61K31/7004A61K33/00A61K33/06A61K33/14A61M1/1654A61M1/1656A61K2300/00
Inventor 梁馨苓符霞宋利刘双信梁华般
Owner GUANGDONG GENERAL HOSPITAL
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