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A kind of chitosan composite dressing and preparation method thereof

A technology for spinning chitosan and chitosan, applied in dressings, viscous dressings, pharmaceutical formulations, etc., can solve problems such as insufficient liquid absorption, avoid whitening and swelling, promote the production of thrombin, and effectively absorb liquid effect

Active Publication Date: 2019-01-29
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite dressing uses an electrospinning method to prepare a chitosan cushion layer, and arranges vent holes on the chitosan cushion layer, and adds a layer of medical water-absorbing cushion layer and waterproof material between the chitosan cushion layer and the medical adhesive tape. Layer, the medical absorbent pad can increase the liquid absorption, and the waterproof layer prevents excessive body fluids from penetrating into the medical tape, solving the problems of the existing chitosan dressings such as air permeability and insufficient liquid absorption

Method used

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  • A kind of chitosan composite dressing and preparation method thereof
  • A kind of chitosan composite dressing and preparation method thereof
  • A kind of chitosan composite dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Such as figure 1 Shown, a kind of chitosan composite dressing comprises chitosan application cushion layer 2, medical absorbent cushion layer 3, waterproof layer 4, medical adhesive tape adhesive layer 5, waterproof layer 4 is covered on the medical adhesive tape adhesive layer 5, and medical absorbent absorbent layer The cushion layer 3 is located between the chitosan cushion layer 2 and the waterproof layer 4. The chitosan cushion layer 2, the medical absorbent cushion layer 3 and the waterproof layer 4 have the same shape and area, and the chitosan cushion layer 2 is covered with a Layer release paper 1, the area is consistent with medical adhesive tape sticking layer 5.

[0034] The area of ​​the chitosan pad layer 2 is smaller than the adhesive layer 5 of medical tape.

[0035] The chitosan pad layer 2 is provided with air vent a, which can increase the air permeability of the dressing, and is oval in shape, and the unique oval design can relieve skin irritation; ...

Embodiment 2

[0044] Step A: Prepare chitosan into a mixed solution with a mass percentage of 3%, the solvent is a mixed solution with a mass percentage of purified water and glycerol of 1:1, stir evenly, and stand for 28 hours to obtain a spinning stock solution ,spare;

[0045] Step B: Under the environment of temperature 25°C and humidity 45%, electrospin the spinning dope, adjust the speed of the micro injection pump to 0.1mL / h, adjust the voltage of the high voltage generator to 18KV, and adjust the speed of the receiving drum The receiving distance is 12cm. By using the power unit to control the horizontal movement and rotation of the receiving drum, the horizontal moving speed of the receiving drum is 0.001mm / s, and the rotating speed of the receiving drum is set to 1000r / s during spinning. sugar spun fibers;

[0046] Step C: soak the chitosan spun fiber in a concentration of 1.0% CaCl 2 Carry out cross-linking in the ethanol solution of cross-linking, after cross-linking 0.5 hour,...

Embodiment 3

[0052] Step A: Prepare chitosan into a mixed solution with a mass percentage of 6%, the solvent is a mixed solution with a mass percentage of purified water and glycerol of 2:1, stir evenly, and stand for 28 hours to obtain a spinning stock solution ,spare;

[0053] Step B: Under the condition of temperature of 25°C and humidity of 45%, electrospinning the spinning stock solution, adjusting the speed of the micro injection pump to 0.1mL / h, adjusting the voltage of the high voltage generator to 15KV, and adjusting the speed of the receiving drum The receiving distance is 15cm. By using the power device to control the horizontal movement and rotation of the receiving drum, the horizontal moving speed of the receiving drum is 0.002mm / s, and the rotating speed of the receiving drum is set to 2500r / s during spinning. sugar spun fibers;

[0054] Step C: soak the chitosan spun fiber in a concentration of 3.0% CaCl 2 Carry out cross-linking in the ethanol solution of cross-linking, ...

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Abstract

The invention discloses a chitosan composite dressing and a preparation method thereof. The composite dressing includes a chitosan pad, a medical absorbent pad, a waterproof layer, and a medical tape adhesive layer. The waterproof layer covers the medical tape adhesive layer, and the medical absorbent pad is located between the chitosan pad and the waterproof layer. There are breathable holes on the chitosan cushion layer. The chitosan cushion layer, the medical absorbent cushion layer and the waterproof layer have the same shape and area. The chitosan cushion layer is covered with a layer of anti-adhesive paper, and the area is the same as the medical tape adhesive layer. The breathable holes and medical absorbent pad on the chitosan dressing layer can ensure the high permeability of moisture and air and avoid whitening and swelling of the wound. The medical absorbent pad adopts an absorbent pad structure with strong water absorption performance, which allows tissue exudate to pass through the breathable holes and be absorbed by the absorbent pad to achieve efficient liquid absorption. The waterproof layer can prevent excessive body fluids from penetrating into the medical tape, making the area covered by the dressing well fixed and not easy to fall off.

Description

technical field [0001] The patent of the invention relates to a medical wound dressing, in particular to a chitosan composite dressing and a preparation method thereof. Background technique [0002] With the development of society, clinical and war wound treatment have higher and higher requirements for local trauma hemostasis. Compared with traditional dressings, biological dressings have better compatibility, less toxic and side effects, low antigenicity, certain water permeability, and It has the advantages of reducing the frequency of wound dressing changes and improving the quality of wound healing. Biomedical materials are considered to be one of the most effective materials for local trauma hemostasis. Chitosan is a natural polymer derived from a wide range of deacetylated chitin. It has good biocompatibility and hemostatic effect, and can prevent the formation of fibrin, the proliferation of connective tissue cells and the synthesis of collagen. It has biological p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/26A61L15/58A61L15/46A61L15/44A61F13/02
CPCA61L15/26A61L15/28A61L15/42A61L15/44A61L15/46A61L15/58A61F13/00063A61F13/0209A61F13/0253A61F13/0289A61L2300/418A61L2300/412A61L2300/41A61L2300/404A61L2400/04A61F13/05C08L5/08C08L67/00
Inventor 黄海艳赵澎车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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