Plasma extraction device based on microfluidic chip

Abstract

The invention discloses a plasma extraction device based on a microfluidic chip. The device comprises a microfluidic chip and a matched driving module. During use, whole blood is added into the microfluidic chip to leave the whole blood to stand for a while, almost red blood cells are settled in the bottom of a reaction chamber, and a small amount of red blood cells and plasma are located in the top layer of the reaction chamber; by means of an external mechanical action force, compression deformation on height of the reaction chamber of the microfluidic chip happens by means of the driving module, and the volume becomes small, so that the plasma and part of red blood cells are discharged out of the reaction chamber through a whole blood filter membrane, the red blood cells are blocked by micropores in the filter membrane while the plasma passes through the filter membrane, and is exported through the micropores of a transfer structural sheet, so that the plasma in the whole blood is extracted. The plasma extraction device based on the microfluidic chip is simple to operate, does not need complicated driving devices, and has an ideal plasma extraction efficiency. The plasma extraction device can be combined with other microfluidic detection modules to separate the plasma in a whole blood sample and detect a landmark of a disease.

Description

technical field [0001] The invention relates to the technical field of rapid diagnosis and detection of diseases, relates to a detection sample pretreatment device, in particular to a microfluidic chip device for preprocessing whole blood samples and rapidly extracting plasma samples. Background technique [0002] So far, most disease diagnosis is often achieved by specific detection of disease markers in human blood samples. Since human whole blood samples contain a large number of red blood cells, in order to achieve reliable and efficient disease detection, it is often necessary to perform pretreatment on whole blood samples, such as filtering out red blood cells, and then testing the extracted plasma samples . Traditional plasma extraction generally needs to rely on a centrifuge, which is achieved by applying centrifugation to the whole blood sample, that is, the red blood cells are deposited to the bottom of the test tube under the action of centrifugal force, and the ...

AI Technical Summary

Problems solved by technology

The disadvantages of the traditional method are that it relies heavily on special equipment such as centrifuges, requires manual operation, and is difficult to combine with subsequent detection methods in the operation mode, which is not conducive to the realization of integrated automatic detection

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