Ultrasonic contrast agent

Abstract

The invention belongs to the field of medical science, and especially relates to an ultrasonic contrast agent. The ultrasonic contrast agent is composed of a solution, and coated gas; the solution is composed of carboxy polymethleme, an alkaline amino acid, a phosphatide, ethanol, polylactic acid, monoglyceride stearate, and a salt solution with a concentration ranging from 1.2 to 2.3%. According to the ultrasonic contrast agent, micro bubbles possess no toxic or side effect; foam film structure is stable; a preparation method is simple and controllable; the ultrasonic contrast agent possesses excellent acoustic responsiveness, can be taken as an effective ultrasonic contrast agent; application range is wide; the particle size of 95% micro bubbles ranges from 2 to 4<mu>m; particle size distribution is uniform; and clinical application prospect is promising.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an ultrasonic contrast agent. Background technique [0002] Cervical cancer is one of the most common malignancies in women worldwide. According to the statistics of the World Health Organization, its incidence rate is second only to breast cancer, and it is gradually getting younger. There are about 466,000 new cases of cervical cancer every year, 80% of which occur in developing countries. There are about 100,000 new cases in my country every year, accounting for 1 / 5 of the total number of new cases in the world. In recent years, there has been an increase in regions and an earlier age of onset. Because of its serious harm to women's health and the social problems it causes, research on cervical cancer has always been the focus of attention. [0003] In recent years, with the development of science and technology, medical imaging has become an important auxiliary means for doctors to...

AI Technical Summary

Problems solved by technology

Its advantages include: safety, non-invasive, low price; simple and convenient operation, no radioactive pollution, no ionizing radiation; fast imaging speed, real-time dynamic image acquisition of changes in tissues and organs, etc.; contrast-enhanced ultrasound technology mainly through intravenous injection of microbubbles State contrast agent, the interface of the scanning object has poor echo acoustic impedance, which can highlight the tumor focus from the surrounding tissue. In the diagnosis of cervical cancer, it can be used as a routine method for cervical cancer screening, and has become one of the hot spots in the research of cervical disease diagnosis; The key to contrast-enhanced ultrasound technology is the contrast agent, and the contrast agent currently used is mainly a microbubble contrast agent. The microbubble contrast agent can clearly display the abnormal perfusion area caused by vascular problems or tissue lesions, thus providing accurate and dynamic clinical results. Tissue perfusion information, however, there are still many problems with this microbubble contrast agent, such as: ① it has no affinity for diseased tissue, and can only perform non-specific imaging on the diseased tissue, and cannot judge the nature of the lesion; ② the microbubble diameter is relatively large (more 2-6 μm level), although they can freely pass through the pulmonary circulation, they cannot penetrate the blood vessel wall to reach the target cells; ③The gas contained in the microbubbles itself has the characteristics of innate reflection and backscattering, which often makes the contrast between the observation target and the background Not strong; ④The half-life is short, and the effective enhancement time is only tens of seconds. For lesions that require a long time to be examined, only repeated injections of contrast agents can meet the requirements. Therefore, in order to improve the detection efficiency of early cervical cancer, this study Through a large number of clinical trials, the author studied a microbubble contrast agent that can maintain the concentration in cervical tissue, prolong the half-life, and detect cervical cancer comprehensively and clearly, providing a new way for the faster and better development of ultrasound contrast technology

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