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Application of radix gentianae in preparing medicine for treating viral hepatitis B

A technology for viral hepatitis and gentian extract, applied in antiviral agents, drug combinations, pharmaceutical formulations, etc., can solve problems such as inability to completely and effectively remove hepatitis B virus

Inactive Publication Date: 2017-07-07
姚萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is currently no specific drug that can completely eliminate HBV in clinical practice.

Method used

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  • Application of radix gentianae in preparing medicine for treating viral hepatitis B
  • Application of radix gentianae in preparing medicine for treating viral hepatitis B
  • Application of radix gentianae in preparing medicine for treating viral hepatitis B

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0014] Experimental example 1 Selection of extraction solvent and rough selection of extraction method

[0015] Get the coarse powder 80 grams of Chinese herbal medicine, test according to the scheme in table 1, test result is as shown in table 2:

[0016] Table 1 Different extraction schemes

[0017] Option One Decoct and extract twice, each time for 2 hours, the amount of water added is 10 times the amount of medicinal materials each time Option II Reflux extraction 2 times, 2 hours each time, add 5% ethanol to 10 times the amount of medicinal materials third solution Reflux extraction 2 times, 2 hours each time, add 40% ethanol to 10 times the amount of medicinal materials Option four Reflux extraction 2 times, 2 hours each time, add 80% ethanol to 10 times the amount of medicinal materials Option five Reflux extraction 2 times, 2 hours each time, add 95% ethanol to 10 times the amount of medicinal materials Option six Optio...

experiment example 2

[0021] Experimental example 2 Investigation on water extraction process of Chinese herbal medicines

[0022] 1. The influence of the processing length of medicinal materials on the paste yield

[0023] Weigh 80g of Chinese medicinal materials, soak the medicinal materials with 10 times the amount of water for 30 minutes, decoct 2 times for 2 hours each time, filter, combine the filtrates, concentrate, and measure the cream yield. The results are shown in Table 3:

[0024] Table 3 Effect of processing length of medicinal materials on ointment yield

[0025]

[0026] It can be seen from the above table 3 that the ointment yield of the coarse powder of medicinal materials is the highest, but because the medicinal liquid is difficult to filter after the coarse powder of medicinal materials is extracted, although the medicinal residues can be squeezed out mechanically during the experiment, it is not suitable for large-scale industrial production; and The extracting rate of med...

experiment example 3

[0043] Experimental Example 3 Extraction Scheme Verification

[0044] According to the optimized test conditions, weigh 10000g of Chinese herbal medicine processed into 1.0cm section, extract twice, add 8 times the amount of water for 30 minutes, decoct for 2 hours, add 8 times the amount of water for decoction for the second time After 2 hours of extraction, the extract was filtered, the filtrate was concentrated, and dried under reduced pressure (at a temperature of 65-75°C and a vacuum of 0.08-0.1Mpa) to measure the yield of the paste. The results are shown in Table 8:

[0045] Table 8 Extraction scheme verification

[0046]

[0047] It can be seen from the above table 8 that it is reasonable and feasible to use the optimized test conditions to extract Chinese herbal medicines.

[0048] The specific method for the determination of the cream yield described in the above experimental example is: take the clear cream concentrated to a relative density of 1.20-1.30 (measureme...

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Abstract

The invention discloses an application of radix gentianae in preparing a medicine for treating viral hepatitis B. The radix gentianae is a radix gentianae extract which is prepared by conducting extracting with water, ethanol or carbon dioxide as a solvent. In accordance with a conventional process, the radix gentianae or the radix gentianae extract is prepared into any one of the following pharmaceutical dosage forms: tablets, capsules, granules, pills and the like. The radix gentianae is applicable to preparation of the medicine for treating the viral hepatitis B; and the medicine, which is suitable for clinical application, is prepared from the radix gentianae. The radix gentianae can obviously reduce a DHBV-DNA titer, an HBsAg level and AST and ALT activities in serum of a hepatitis B model duck; within 7 days of drug withdrawal, a recurrence phenomenon is avoided; and in addition, the radix gentianae can relieve degeneration of hepatic cells and inflammatory cell infiltration. It is indicated that the composition (the medicine) is obvious in effect of resisting hepatitis B virus of the duck; therefore, it is indicated that the composition (the medicine) has a clinical application value. The pharmaceutical preparation of the medicine for treating the viral hepatitis B is scientific and reasonable.

Description

technical field [0001] The invention relates to a new clinical application of gentian in the preparation of medicines for treating hepatitis B, and belongs to the technical field of pharmacy. Background technique [0002] Hepatitis B virus (Hepatitis B virus, HBV) has been plagued by humans worldwide since its discovery in the 1960s. Although many countries have widely implemented immunization programs, according to the report of the World Health Organization (WHO), Of the 6 billion people in the world, 1 / 2 live in areas with high HBV prevalence, about 2 billion people have been proven to be infected with HBV, 300-400 million people are chronically infected with HBV, and 25%-40% of them will eventually die of liver cirrhosis and liver cancer. Among the top 10 causes of death in the world, viral hepatitis B ranks 7th, with approximately 750,000 deaths due to viral hepatitis every year (http: / / www.who.lnt / csr / disease / hepatitis / ). Compared with other countries in the world,...

Claims

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Application Information

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IPC IPC(8): A61K36/515A61P1/16A61P31/20
CPCA61K36/515A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 不公告发明人
Owner 姚萍
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