Application of Tribulus tts-12, traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes and its preparation method

A technology of TTS-12, TTS-120.8%, applied in the field of traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes and its preparation field, can solve the problem of low bacteriostatic concentration, unpredictable bacteriostatic effect of Tribulus terrestris TTS-12, and bacteriostatic effect. Problems such as poor effect, to achieve the effect of simple components, good anti-fungal infection, easy to clean

Active Publication Date: 2020-03-17
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tribulus TTS-12 is a spirosterane-type saponin extracted from the whole plant of Tribulus terrestris. Studies have found that Tribulus TTS-12 has a strong inhibitory effect on Candida albicans and Cryptococcus neoformans, with MIC values ​​of 1 μg / mL and 2μg / mL, however, the antibacterial effect on Sporothrix schenckii, which is also a fungus, is poor, and the minimum inhibitory concentration is greater than 128μg / mL
Therefore, the antibacterial effect of Tribulus TTS-12 against different strains is unpredictable

Method used

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  • Application of Tribulus tts-12, traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes and its preparation method
  • Application of Tribulus tts-12, traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes and its preparation method
  • Application of Tribulus tts-12, traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, Chinese medicine gel 1

[0030] A traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes, which consists of the following components in terms of mass percentage: Tribulus TTS-12 0.8%, Carbomer 940 1.5%, Glycerin 15%, TTS-12 latent solvent 29.2% , triethanolamine 2.025%, ethylparaben 0.03%, and the balance is distilled water; wherein, the TTS-12 latent solvent is composed of 70% ethanol and propylene glycol in a mass ratio of 3:7.

Embodiment 2

[0031] Embodiment 2, Chinese medicine gel 2

[0032] A traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes, which consists of the following components in terms of mass percentage: Tribulus TTS-12 1%, Carbomer 940 1.5%, Glycerin 5%, TTS-12 latent solvent 29% , triethanolamine 2.025%, ethylparaben 0.03%, and the balance is distilled water; wherein, the TTS-12 latent solvent is composed of 70% ethanol and propylene glycol in a mass ratio of 3:7.

Embodiment 3

[0033] Embodiment 3, Chinese medicine gel 3

[0034] A traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes, which consists of the following components in terms of mass percentage: Tribulus TTS-12 0.5%, Carbomer 940 1%, Glycerin 15%, TTS-12 latent solvent 29.5% , triethanolamine 1.35%, ethylparaben 0.03%, and the balance is distilled water; wherein, the TTS-12 latent solvent is composed of 70% ethanol and propylene glycol in a mass ratio of 3:7.

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Abstract

The invention discloses a new application of Tribulus terrestris TTS‑12, a traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes and a preparation method thereof. Tribulus TTS‑12 has the effect of inhibiting Trichophyton mentagrophytes; the traditional Chinese medicine gel using Tribulus TTS‑12 as a single main drug of the present invention has significantly higher antibacterial activity in vitro than bifonazole gels on the market, and in vivo The anti-infection effect of guinea pigs is equivalent to that of terbinafine hydrochloride cream on the market, showing a good anti-fungal infection effect; the composition of the traditional Chinese medicine gel of the present invention is simple and easy to obtain, low in cost, good in comfort after coating, and easy to clean , is more suitable for private infection sites, and the prepared gel has a good release effect in vitro and can achieve a good anti-trichophyton mentagrophyte effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and more specifically relates to a new application of Tribulus terrestris TTS-12, a traditional Chinese medicine gel for inhibiting Trichophyton mentagrophytes and a preparation method thereof. Background technique [0002] Trichophyton mentagrophytes, also known as gypsum-like Trichophyton, is one of the more common and most easily isolated dermatophytes from humans and animals. It can not only cause tinea corporis, tinea manus, pedis, Ringworm diseases such as onychomycosis and tinea capitis can also cause deep infections such as pyogenic tinea, abscess and granuloma. Ringworm is extremely stubborn, and recurrence and reinfection often occur, and existing medicines are difficult to achieve a radical cure. [0003] Taking tinea corporis as an example, its treatment is based on western medicine, and the commonly used western medicine antibacterial drugs include antifungal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/06A61K47/32A61P31/10A61P31/02
CPCA61K9/0014A61K9/06A61K31/7048A61K47/32
Inventor 吴新荣谭翠雯彭海莹陈龙浩黄木土
Owner GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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