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Applications of icariin in preparation of medicines treating arrhythmia

A technology of arrhythmia and icariin, applied in the direction of drug combination, pharmaceutical formula, cardiovascular system diseases, etc., to achieve the effect of reducing the incidence rate

Inactive Publication Date: 2017-06-30
WUHAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effects of icariin on cardiomyocyte action potentials, various ion channel currents, and arrhythmias at the overall (in vivo) level have not been reported.

Method used

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  • Applications of icariin in preparation of medicines treating arrhythmia
  • Applications of icariin in preparation of medicines treating arrhythmia
  • Applications of icariin in preparation of medicines treating arrhythmia

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Experimental program
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Embodiment Construction

[0041] In order to verify the technical effect of the present invention, this specific embodiment illustrates the new application of icariin in the field of pharmacy through research at the cell level and the overall level.

[0042] 1 material

[0043] 1.1 Animals

[0044] Healthy adult New Zealand big-eared rabbits, weighing 1.7-2kg, regardless of sex, were provided by the Animal Experiment Center of Wuhan University of Science and Technology.

[0045] 1.2 Main instruments

[0046] EPC9 patch clamp amplifier (Heka Electronic, Germany); three-dimensional micromanipulator (Sutter, USA); fluorescent inverted microscope (Nikon, Japan); two-step glass microelectrode puller (Narishige, Japan); constant-speed pump (Baoding Shenchen Pump Industry Co., Ltd.).

[0047] 1.3 Drugs and reagents

[0048] Type I collagenase and CsCl were purchased from Gibco Company in the United States; taurine, serum albumin and HEPES were purchased from Roche Company in Switzerland; glutamic acid and...

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Abstract

The invention belongs to the technical field of icariin applications, and discloses applications of icariin in preparation of medicines treating arrhythmia. According to a technical scheme, the medicines are capsules, micro-capsules, lipidosomes, granules, injections, tablets or oral liquids. Beneficial effects of the applications are that the icariin can prolong occurrence time (a time threshold) and increase the using amount (a dosage threshold) for arrhythmia induced by aconitine under a whole (living body) condition, and the icariin can effectively reduce the occurrence rates of ventricular tachycardia and ventricular fibrillation which are induced by the aconitine and the death rate of New Zealand big-ear rabbits. The icariin can retard instantaneous sodium current (I<NaT>), late sodium current (I<NaL>) and L-type calcium current (I<CaL>) and plays a role of an arrhythmia preventing medicine. The icariin has no obvious effects on inward rectifier potassium current (I<K1>) of left-ventricular muscle (LVM), rapid delayed rectifier potassium current (I<Kr>), instantaneous outward potassium current (I<to>) of left atrial muscle (LAM) and ultra-rapidly activated delayed rectifier potassium current (I<Kur>), thus improving medication safety.

Description

technical field [0001] The invention belongs to the technical field of icariin. It specifically relates to the application of icariin in the preparation of drugs for treating arrhythmia. Background technique [0002] Arrhythmia is due to abnormal sinoatrial node excitation or excitation outside the sinoatrial node, slow conduction of excitation, blockage or conduction through abnormal channels, that is, the origin of cardiac activity and (or) conduction disorders leading to cardiac beat frequency and (or ) abnormal rhythm. Arrhythmia is an important group of diseases in cardiovascular diseases. It can occur alone or accompany other cardiovascular diseases. Its prognosis is related to the etiology, inducement, evolution trend of arrhythmia, and whether it leads to severe hemodynamic disturbance. Arrhythmia can be caused by various organic cardiovascular diseases (such as hypertension, myocardial ischemia and myocardial infarction, myocardial injury, etc.), drug poisoning, ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/06
CPCA61K31/7048
Inventor 马季骅蒋晚珍张培华曾梦柳曹珍珍刘志沛
Owner WUHAN UNIV OF SCI & TECH
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