A kind of invisible and revealable silk fibroin nursing film base and preparation method thereof

Abstract

The application field of silk fibroin of the present invention, especially relates to an invisible and detachable silk fibroin care film base and its preparation method; The mass fraction of vegetarian protein is 0.5-5%, the mass fraction of the moisturizing agent is 5-50%, the mass fraction of the thickener is 1%-6%, and the balance is water; its preparation method includes the following steps : S1, add humectant to silk fibroin solution in proportion, and mix uniformly to form a mixed solution; S2, add thickener to the mixed solution, mix evenly to obtain the nursing film base; the invisible and detachable silk fibroin of the present invention Protein care film and its preparation method, the raw materials are pure natural, the preparation method and steps are simple, the substrate is evenly applied on the skin for about 10min-15min, and an invisible film with aesthetic effect can be formed in situ. The film material is similar to skin and easy to peel off , In addition, this substrate has good compatibility with active substances.

Description

technical field [0001] The invention relates to the application field of silk fibroin, in particular to an invisible and detachable silk fibroin care film substrate and a preparation method thereof. Background technique [0002] The material made of natural high molecular weight (>100KDa) silk fibroin has good biocompatibility, is biodegradable, non-toxic, and has good film-forming properties, and can prepare a variety of silk fibroin-based biomaterials. Silk fibroin film has good moisture absorption and air permeability, and has been used in tissue engineering and drug sustained release systems, such as artificial skin. For silk fibroin, it is a natural high-molecular fiber protein extracted from silk, which accounts for about 70% to 80% of silk, and contains 18 kinds of amino acids, including glycine (gly), alanine (ala) and serine ( Ser) accounts for more than 80% of the total composition, among which leucine can accelerate cell metabolism, serine and threonine can de...

AI Technical Summary

Problems solved by technology

[0006] In the preparation of detachable care products, there are several preparation methods as follows: 1) The first is the traditional method, at first preparing sheet materials, such as non-woven materials, and then combining functional substances on the sheet materials, or According to the principle of physical adsorption, soak the sheet material in functional substances to prepare general care products, or continue coating to prepare composite scaffolds with special purposes. The most obvious feature of this material is that it is a shaped product before use. Sometimes it only needs to be pasted on a specific part to achieve the effect of nursing, such as facial masks, while some other therapeutic and repair products still rely on the use of cumbersome dressings, which are often used in combination with external ointments. Due to poor patient compliance, often fail

2) The second type is jelly mask, jelly mask is a mask added with colloids such as kabomu and aloe vera. It can be applied to the face like a night cream to sleep, and can be washed off the next day. But after applying it on the face, the skin care Most of the products are easy to stick to the pillow or bedding, which is not very convenient to use

Chinese patent CN201410537752.1 discloses a peelable mask matrix based on water-based polyurethane dispersion system. It is formulated, this kind of matrix fits the skin completely, and it becomes a transparent film after drying, it does not fall off, it has the effect of firming the skin and removing dead skin dirt, but when peeling off, it needs to be wetted with water before it can be removed, and the polyurethane The synthesis of raw materials is complicated, and volatile organic solvents such as acetone are used in the intermediate extraction steps, and the residues are likely to have adverse effects on the skin

Chinese patent CN201610601512.2 discloses a peel-off mask. The formula is composed of agent A and agent B. Agent A is composed of candilan gum, glycerin, sodium hyaluronate and water, while agent B is prepared from trehalose and water. A spray is obtained. When using it, apply A agent on the face to form a uniform film, then spray B agent on the surface of A agent, and peel it off after 15-20 minutes. The film has good moisturizing effect and water-locking ability. Strong, it will not cause tearing to the skin when peeling off, but it needs two steps, the operation is complicated, and A and B agents are indispensable, the ratio of the two agents is not easy to control during the use of A agent and B agent, and it is not universally applicable , which is cumbersome to use

At the same time, the presence of polysiloxane film can better help the skin moisturize, which can be used in skin care products or cosmetics, and can also be applied to medical skin, but the ingredients in the first and second steps are complicated, and the two The step-by-step operation is also relatively cumbersome, and it needs to be applied evenly when applying the first layer, and then continue to apply the second layer, which is time-consuming. The best solution is to prepare this film-forming material in one step.

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