Detection method for functions of platelets

Abstract

The invention discloses a detection method for functions of platelets. The detection method is used for analyzing and evaluating the functions of the platelets and comprises platelet detection as follows: (1) carrying out platelet activated detection; (2) carrying out blood clotting factor activated detection; (3) carrying out platelet inhibited detection. The detection method is applicable to the platelet function determination of a thromboelastography by a clotting method, and a platelet function detection result is obtained through separately adding obtained platelet detection values in a detected blood sample and carrying out further calculation. According to the method, by adopting a platelet inhibitor, a detection value serves as a background control parameter in platelet function analysis, and thus, the detection result is more reliable. Compared with the former detection methods, the method has the advantages that expensive hemocoagulase is not required to be used, so that the detection cost is reduced, and the method is applicable to clinical popularization.

Description

technical field [0001] The invention relates to the technical field of in vitro diagnosis, in particular to a platelet function detection method. Background technique [0002] Thrombotic diseases (such as myocardial infarction, cerebral infarction, etc.) have high morbidity, high disability and high mortality, and have become the leading cause of death in the world. Platelets play a key role in thrombosis and are also the cause of arterial thrombosis. major factor. In medical clinical practice, antiplatelet drugs are also used as the main measures for the treatment and prevention of thrombotic diseases. Medical research has demonstrated an increased risk of thrombotic and bleeding disorders when platelet function is abnormal. Therefore, in order to maintain the body in a healthy state and avoid the occurrence of thrombosis or hemorrhagic diseases, it is necessary to control the platelet function within a reasonable range of functional status. [0003] Clinical significanc...

AI Technical Summary

Problems solved by technology

[0008] However, the detection technology of thromboelastography was produced before the 1970s. Although it is now widely used in clinical practice, due to the relatively backward production technology and detection methods in the past, the coagulation method based on thromboelastography is used to detect platelet function. The error of the result is large, and because of the high cost, it affects its clinical value. Now, due to the update of new biochemical synthesis technology, molecular biotechnology and detection technology, a new detection method of platelet function is now provided. , in order to improve the reliability of detection and reduce the cost of detection, solve the same problems in the existing detection technology, as a platelet function detection method that is more suitable for clinical application