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Method for preparation of pharmaceutical adjuvant silica by bipolar membrane electrodialysis

A bipolar membrane electrodialysis and silica technology, applied in the field of ion exchange membranes, can solve the problems of long production process, long preparation time, expensive raw materials of sol-gel method, etc. Effect

Active Publication Date: 2017-06-20
HUAINAN UNITED UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among these methods, the gas phase method has expensive raw materials, high equipment requirements, long production process, and high energy consumption; the chemical precipitation method has the problem of low product purity; the sol-gel method has expensive raw materials and long preparation time; and the microemulsion method has high costs. , Organic matter is difficult to remove and easily pollutes the environment

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  • Method for preparation of pharmaceutical adjuvant silica by bipolar membrane electrodialysis
  • Method for preparation of pharmaceutical adjuvant silica by bipolar membrane electrodialysis
  • Method for preparation of pharmaceutical adjuvant silica by bipolar membrane electrodialysis

Examples

Experimental program
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Effect test

Embodiment 1

[0057] 1.1 Soak the titanium sheet in concentrated hydrochloric acid until it softens, take it out, wash it several times with distilled water, and then dry it to obtain a dried titanium sheet.

[0058] 1.2 Put the dried titanium sheet into a polytetrafluoroethylene reactor containing 50ml of an aqueous solution containing 4.0mmol cobalt nitrate, 8mmol ammonium fluoride and 20mmol urea, and react at 80°C for 12h to make the titanium sheet Oriented basic cobalt carbonate nanowires grow on the surface.

[0059] 1.3 Put the oriented-type basic cobalt carbonate nanowire titanium sheet grown on the surface obtained in step 1.2 into a polytetrafluoroethylene reactor filled with 20ml of an aqueous solution containing 4.2g 2-methylimidazole and 3.3g triethylamine In the process, at 100° C. for 100 minutes, the alignment-type cobalt basic carbonate nanowires on the surface of the titanium sheet were converted into alignment-type ZIF-67 nanotubes.

[0060] 1.4 Soak the titanium sheet w...

Embodiment 2

[0073] 2.1 Soak the titanium sheet in concentrated hydrochloric acid until it softens, take it out, wash it several times with distilled water, and then dry it to obtain a dried titanium sheet.

[0074] 2.2 Put the dried titanium sheet into a polytetrafluoroethylene reactor containing 50 ml of an aqueous solution containing 5.0 mmol of cobalt nitrate, 9.4 mmol of ammonium fluoride and 29.4 mmol of urea, and react for 13 hours at a temperature of 75 ° C, so that Oriented basic cobalt carbonate nanowires grow on the surface of the titanium sheet.

[0075] 2.3 Put the oriented-type basic cobalt carbonate nanowire titanium sheet grown on the surface obtained in step 2.2 into a polytetrafluoroethylene reactor filled with 20ml of an aqueous solution containing 5.6g of 2-methylimidazole and 4.8g of triethylamine , at a temperature of 90° C., reacted for 150 minutes, and the orientation-type basic cobalt carbonate nanowires on the surface of the titanium sheet were converted into orie...

Embodiment 3

[0084] 3.1 Soak the titanium sheet in concentrated hydrochloric acid until it softens, take it out, wash it several times with distilled water, and then dry it to obtain a dried titanium sheet.

[0085] 3.2 Put the dried titanium sheet into a polytetrafluoroethylene reactor containing 50 ml of an aqueous solution containing 6.0 mmol of cobalt nitrate, 10.0 mmol of ammonium fluoride and 26.5 mmol of urea, and react for 11 hours at a temperature of 90 ° C, so that Oriented basic cobalt carbonate nanowires grow on the surface of the titanium sheet.

[0086] 3.3 Put the oriented-type basic cobalt carbonate nanowire titanium sheet grown on the surface obtained in step 3.2 into a polytetrafluoroethylene reactor filled with 20ml of an aqueous solution containing 4.5g 2-methylimidazole and 3.7g triethylamine , at a temperature of 80°C, reacted for 200 minutes, and the orientation type basic cobalt carbonate nanowires on the surface of the titanium sheet were converted into orientation...

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Abstract

The invention discloses a method for preparation of pharmaceutical adjuvant silica by bipolar membrane electrodialysis. The method includes the steps of: 1. membrane preparation, which specifically comprises the steps of: A), growing oriented ZIF nanotubes on a metal sheet surface to obtain an intermediate, wherein the oriented ZIF nanotubes include cobalt ions; B), soaking the intermediate in a high polymer solution to obtain an oriented ZIF based anion-exchange membrane, wherein the high polymer in the high polymer solution contains benzyl chloride or benzyl bromide groups; 2. placing the oriented ZIF based anion-exchange membrane in a bipolar membrane electrodialysis device to prepare an orthosilicic acid multimer by bipolar membrane electrodialysis; and 3. heating the orthosilicic acid multimer prepared by the step 2 to obtain silica. The method provided by the invention employs bipolar membrane electrodialysis to prepare the pharmaceutical adjuvant silica, and provides a new preparation process for preparation of the pharmaceutical adjuvant silica.

Description

technical field [0001] The invention relates to the technical field of ion exchange membranes, in particular to a method for preparing silicon dioxide as a medical auxiliary material by using bipolar membrane electrodialysis. Background technique [0002] Silicon dioxide is a new type of excipient currently used in pharmaceutical preparations. In the process of tablet production, silicon dioxide can greatly improve the fluidity of granules, increase the bulk density, increase the hardness of the prepared tablet, and shorten the disintegration time limit. , thereby increasing the drug dissolution rate. As an excellent disintegration aid, excipient, and binder, it is favored by more and more pharmaceutical companies. [0003] The traditional preparation methods of silica include gas phase method using silane halide as raw material; chemical precipitation method using sodium silicate and inorganic acid as raw material; and sol-gel method and microemulsion method using silicate...

Claims

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Application Information

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IPC IPC(8): C01B33/12B01D61/42B01D61/44B01D61/46
CPCB01D61/422B01D61/445B01D61/46C01B33/12C01P2004/03C01P2006/80
Inventor 伍斌何晓文崔洪珊
Owner HUAINAN UNITED UNIVERSITY
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