Preparation technology for centella extract

Abstract

The invention discloses a preparation technology for a centella extract. The preparation technology at least comprises the following steps: 1) acquiring an extract solution from a centella raw material; 2) performing flocculation treatment on the extract solution acquired in the step 1) and filtering, thereby acquiring a flocculation extract; 3) performing subsequent treatment on the flocculation extract, thereby acquiring the centella extract. According to the scheme provided by the invention, a flocculation system is introduced into an extract solution system through a flocculation process, so that the effect of removing the electrified foreign particles can be enhanced, the pollution resulted from the secondarily introduced foreign particles is difficult to occur and the quality of the extract is increased.

Description

technical field [0001] The invention relates to a method for purifying plant active ingredients, in particular to a preparation process for Centella asiatica extract. Background technique [0002] Centella asiatica is a perennial creeping herb. Alias: Shibaque, Bengdawan, Callagrass, Gotu Kola, Cocklegrass, Coppermoss, Luodeda, etc. Born in damp wastelands, beside villages, roadsides, and ditches. The stem prostrates to the ground and takes root at the nodes. The leaves are alternate, with long petioles; the leaves are round or reniform, 2-4 cm in diameter. Centella Asiatica (L.) Urban is the dried or rooted whole plant of Centella asiatica (L.) Urban, a dicotyledon Umbelliferae. Contains a variety of α-amyresin-type triterpenes, including Asiaticoside, Thankuniside, Isothankuniside, Madecas-soside ), Brahmoside, Brah-minoside and Brahmicacid, and Madasiatic acid. Centella asiatica has many pharmacological effects: 1) Central effect: the glycosides contained therein ha...

AI Technical Summary

Problems solved by technology

Although this method can obtain high-purity madecassoside single product, it uses the asiaticoside extract with a weight content of 30-97% as a raw material for separation and purification, and a certain amount must be extracted from centella asiaticoside first. content of asiaticoside extract; in addition, the price of equipment used in this method for preparative high-performance liquid chromatography is relatively high, resulting in high production costs of products

[0004] In the prior art, the extraction method of Centella asiatica extract generally uses macroporous resin purification as the main separation step after extraction. However, using macroporous resin purification method, the resin needs to be treated before use, and the purification needs to be absorbed and eluted. process, long production cycle

When using a macroporous resin for purification and elution, due to physical adsorption, it is easy to cause a part of the sample to be deadly adsorbed, resulting in a decrease in the transfer rate

In addition, the volume of eluent purified by macroporous resin is large, and the solvent recovery time is long, which increases the production cost, and the solvent recovery produces more waste liquid, which causes a certain burden on environmental protection.

In addition, due to the use of macroporous resins, the risk of introducing organic residual solvents such as benzene, toluene, xylene, styrene, alkanes, and diethylbenzene has increased, which has a certain impact on product safety.

[0005] In addition, when extracting, the macroporous resin is used for physical adsorption directly through the column, and the remaining small particles of impurities are easy to remain and cause column pollution, and at the same time affect the elution quality, thereby reducing the extraction quality