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Purpose of angelicin to preparation of medicine for treating hyperlipemia

A technology for isopsoralen and hyperlipidemia, which can be used in drug combinations, active ingredients of heterocyclic compounds, metabolic diseases, etc., and can solve problems such as increased risk and liver damage

Active Publication Date: 2017-06-06
新疆维吾尔自治区维吾尔医药研究所
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  • Claims
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Problems solved by technology

In addition, existing statins can induce adverse reactions such as abnormal liver enzymes and rhabdomyolysis, and even cause liver damage. Taking fibrates and statins, two lipid-lowering drugs at the same time, can cause liver and kidney damage and rhabdomyolysis. The risk will increase significantly

Method used

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  • Purpose of angelicin to preparation of medicine for treating hyperlipemia
  • Purpose of angelicin to preparation of medicine for treating hyperlipemia
  • Purpose of angelicin to preparation of medicine for treating hyperlipemia

Examples

Experimental program
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Effect test

Embodiment

[0013] Experimental study on the lipid-lowering effect of isopsoralen on hyperlipidemic rats:

[0014] Objective: To study the effect of isopsoralen on blood lipids in hyperlipidemic rats. Methods: The hyperlipidemia rat model established by feeding high-fat diet was treated with isopsoralen by oral gavage for 4 weeks, and the four items of blood lipids were measured. Results: Compared with the model group, isopsoralen could decrease TC, TG, LDL-C and increase HDL-C in hyperlipidemic rats. Conclusion: Isopsoralen has a certain regulatory effect on lipid metabolism in hyperlipidemic rats;

[0015] Key words: isopsoralen; hyperlipidemia; rats;

[0016] 1 Material:

[0017] 1.1 Experimental animals: healthy SD male rats, weighing 180-220g; provided by Xinjiang Experimental Animal Research Center, experimental animal production license number: SCXK (new) 2011-0001;

[0018] 1.2 Experimental instruments and main reagents: four blood lipid reagents are provided by Shenzhen Mindr...

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Abstract

The invention belongs to the technical field of medicine, and relates to a purpose of angelicin to preparation of medicine for treating hyperlipemia. Pharmacology tests show that the angelicin has a good treatment effect on a hyperlipemia rat model for the first time. The treatment effect of the angelicin on a hyperlipemia dyslipidemia rat model built for high-fat feed feeding is systemically studied; the result shows that the angelicin has an obvious treatment effect on the hyperlipemia rat model; the TC (total cholesterol), the TG (triglyceride) and the LDL-C (low density lipoprotein cholesterin) of a hyperlipemia rat are reduced; the HDL-C (high density lipoprotein cholesterin) is increased; meanwhile, the effect of simultaneously reducing the cholesterol and the triglyceride of the hyperlipemia rat is achieved.

Description

technical field [0001] The invention relates to the use of isopsoralen in the preparation of medicines for treating hyperlipidemia. Background technique [0002] Dyslipidemia is the abbreviation of abnormal blood lipid metabolism, mainly refers to triglyceride (Triglyceride, abbreviated TG), low-density lipoprotein cholesterol (abbreviated LDL-C), total cholesterol (abbreviated TC) exceeds the normal range and (or ) High-density lipoprotein cholesterol (abbreviated HDL-C) is low; hyperlipidemia, which is often called clinically, mainly refers to the increase of TC and (or) LDL-C and (or) TG. In recent years, human living conditions and lifestyles have been greatly improved, with a wide variety of diets and rich nutrition, but the corresponding exercise and rest have not increased, resulting in more and more metabolic diseases, hyperlipidemia is one of them , the incidence rate is increasing day by day. Modern studies have shown that atherosclerosis, diabetes and other dise...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61P3/06
CPCA61K31/37
Inventor 李治建斯拉甫·艾白窦勤尤力都孜·买买提
Owner 新疆维吾尔自治区维吾尔医药研究所
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