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A novel compound isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the composition comprising the same for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof

A TECHNOLOGY FOR ALLERGIC DISEASES, CORONARY OBSTRUCTIVE APPLICATIONS TO NOVEL COMPOUNDS ISOLATED FROM PSEUDOLYSIMACHION ROTUNDUM VAR.SUBINTEGRUM CONTAINING LARGE ACTIVE INGREDIENTS FOR THE PREVENTION OR TREATMENT OF ALLERGIC DISEASES, INFLAMMARY DISEASES, ASTHMA OR CORONARY OBSTRUCTIVE Pulmonary disease compositions containing the compounds and their fields of use, capable of solving the problems of not exhibiting anti-inflammatory activity, anti-allergic activity, anti-asthma activity, and anti-COPD activity

Active Publication Date: 2017-05-31
YUNGJIN PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] However, in the literature cited above (the disclosure of which is incorporated herein by reference), there is no information about the extract isolated from Pseudolysimachion rotundum var. subintegrum showing anti-inflammatory activity, antiallergic activity, antiasthma activity and Report or disclosure of new compounds with anti-COPD activity

Method used

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  • A novel compound isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the composition comprising the same for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof
  • A novel compound isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the composition comprising the same for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof
  • A novel compound isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the composition comprising the same for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof

Examples

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Embodiment

[0093] The following reference examples, examples and experimental examples are intended to further illustrate the present invention without limiting its scope.

reference example 1

[0094] Reference example 1. Analyzer

[0095]Melting point was measured by melting point measuring device (Koflermicrohostage) (without correction); optical rotation was measured by Jasco P-1020 polarimeter; UV data was measured by UV-VIS 2450 spectrometer; FT-IR spectrum was measured by Jasco FT / IR-4200 ; NMR spectra were determined by Varian UNITY 400MHz FT-NMR spectrometer using TMS as internal standard; HRESIMS was determined by Waters Q-TOF Premier spectrometer; and HPLC was performed by Gilson HPLC using UV / VIS-155 detector and pump 305 in the experiments analyze.

Embodiment 1

[0096] Example 1: Preparation of new compound (KS534) from Pseudolysinachion rotundum var. subintegrum

[0097] 1-1. Preparation of Crude Extract

[0098] 2.0 kg of dried Pseudolysimachion rotundum var.subintegrum (according to GAP, KRIBB0020697, KRIBB's plant extract bank, cultivated in Soi-myeon Eumseong-gun Chungcheongbuk-do, 244, Korea; Taejeon, Korea) was cut into small pieces, and mixed with 10 L 40% ethanol mix. The mixture was stirred at room temperature for 24 hours and reflux extracted at 78° C. for 12 hours three times to collect the filtrate. Filter the extract with filter paper to remove residue. The collected filtrate was concentrated under reduced pressure at 55°C-65°C by a rotary evaporator (EYELA, N-2100, Japan), and dried with a freeze dryer to obtain 198.7 g of dried crude extract.

[0099] 1-2. Preparation of purified extract

[0100] 20 g of the dried crude extract was dissolved in a mixed solvent (25% MeOH-water) and further purified by using preparat...

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Abstract

The present invention relates to a novel methanocyclopenta[e][1,3]dioxepin-7-yl 3,4-dihydroxybenzoate derivative (KS534) represented below as the Chemical Formula 1, the pharmaceutically acceptable salt or solvates thereof, a composition comprising the same as an active ingredient for preventing or treating allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease (COPD) and the use thereof.

Description

technical field [0001] The present invention relates to novel compounds isolated from Pseudolysimachion rotundum var. subintegrum, compositions containing the compounds for preventing or treating allergic diseases, inflammatory diseases, asthma or chronic obstructive pulmonary disease, and their uses. Background technique [0002] In general, an inflammatory response is a normal response of the human body associated with edema, pain, etc. in case of any infection of a tissue or cell causing some organic change of the tissue or cell. Recently, various types of cytokines have been found to be involved in inflammatory diseases. [0003] Allergic reactions can be divided into four categories according to the type of response, namely, type I, type II, type III, and type IV, or according to the type of time period from the time of resensitization caused by the allergen to the time of onset of the reaction. Sexual reactions are divided into two categories, namely, immediate allerg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08A61K31/357A61P37/08A61P29/00A61P11/06A61P11/00A23L33/00
CPCA61K36/80C07H17/04C07D493/08A61K31/357A61P11/00A61P11/06A61P11/16A61P29/00A61P37/08A61K31/36C07D321/06A61K31/7048A23L33/105A23L33/16A23L33/15A23L33/155A23L2/52A23V2002/00A61K36/68
Inventor 李容男柳志石申大熙柳炳焕吴世湸安境燮李炯圭李洙义宋赫桓申寅植柳亨杬
Owner YUNGJIN PHARM CO LTD
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