Poly(phthalazinone ether) provided with composite coating on surface and preparation method of poly(phthalazinone ether)

A technology of naphthalene polyarylether and composite coating, which is applied in the field of polymer science, can solve the problem that the biocompatibility of polyarylene naphthalene cannot meet the needs of bone implant materials, and achieve improved biocompatibility , good biocompatibility, and broad application prospects

Active Publication Date: 2017-05-31
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biocompatibility of polyaryl ethers cannot meet the requirements of bone implant materials. The present invention intends to modify the surface of polyaryl ethers with bone-like apatite biomimetic mineralization to improve its biocompatibility. compatibility

Method used

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  • Poly(phthalazinone ether) provided with composite coating on surface and preparation method of poly(phthalazinone ether)
  • Poly(phthalazinone ether) provided with composite coating on surface and preparation method of poly(phthalazinone ether)
  • Poly(phthalazinone ether) provided with composite coating on surface and preparation method of poly(phthalazinone ether)

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Experimental program
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Effect test

Embodiment 1

[0039] In the first step, a polydopamine layer is deposited on the surface of the PPBES sheet by self-polymerization of dopamine. Sonicate the PPBES sheet by immersing it in acetone for 10 to 20 minutes, immerse it in isopropanol for 10 to 20 minutes, and immerse it in ultrapure water for 10 to 20 minutes. Use Tris aqueous solution as a buffer solution, prepare 10 mL of dopamine aqueous solution with a concentration of 2 mg / mL, adjust the pH value to 8.5, add 0.5 g of washed PPBES tablets into the dopamine aqueous solution, and react at 45 °C for 2 days , take out the modified PPBES sheet, rinse it with ultrapure water 5 times, 30s each time. Dry in a vacuum oven at 60°C to obtain polydopamine-modified PPBES sheets.

[0040] In the second step, bone-like apatite is deposited on the surface of the polydopamine-modified PPBES sheet prepared in the first step. At room temperature, the polydopamine-modified PPBES sheet was soaked in Na + 、K + , Mg 2+ , Cl - 、HCO 3 - , SO ...

Embodiment 2

[0047] In the first step, a polydopamine layer is deposited on the surface of the polyaryl ether sulfone ketone (PPBESK) material through dopamine self-polymerization. As described in the first step of Example 1.

[0048] In the second step, the surface of the polydopamine-modified PPBESK sheet prepared in the first step is modified by phosphorylation. 1cm 2 The xaphthalene polyarylether tablets were immersed in 3.5 mL of different concentrations of POCl 3 In the acetonitrile solution, put it in an ice bath, react for 2 hours, suck out the solution, add 3.5mL of acetonitrile, let it stand for 5 minutes, then add 30mL of water, let it stand for 5 minutes, suck out the mixed solution, add 10mL of water, washed for 5 minutes, repeated washing 4 times, and the samples were dried for later use.

[0049] In the third step, bone-like apatite is deposited on the surface of the modified polydopamine layer prepared in the second step. As described in the second step of Example 1.

...

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Abstract

The invention provides poly(phthalazinone ether) provided with a composite coating on the surface and a preparation method of the poly(phthalazinone ether) and belongs to the technical field of polymer science. The composite coating of the poly(phthalazinone ether) provided with the composite coating on the surface comprises a polydopamine layer and a bone-like apatite layer, wherein the polydopamine layer comprises a polydopamine layer not modified with a phosphoric acid functional group and a polydopamine layer modified with the phosphoric acid functional group, and the thickness of the polydopamine layer is smaller than 1 mu m; the bone-like apatite layer contains Ca and P, and the thickness is smaller than 1 mu m. The preparation method of the poly(phthalazinone ether) comprises steps of surface deposition of polydopamine and biomimetic mineralization of bone-like apatite, adopts a simple process, and is low in cost. The bone-like apatite layer can improve properties including surface hydrophilicity and biocompatibility of polyarylether.

Description

technical field [0001] The invention belongs to the field of polymer science and technology, and relates to a polymer material with similar mechanical properties to bone and a surface modification method thereof, in particular to a bone-like apatite layer and its Biomimetic mineralization preparation method. Background technique [0002] Biomedical materials are a class of materials used to diagnose, treat, repair or replace diseased tissues and organs or enhance their functions. Bone repair materials are one of the biomedical materials with the greatest clinical demand. As a kind of bone repair materials, bone implant materials have always been paid attention to by people. Compared with the potential metal ion release of metal bone implant materials, radiopacity and mechanical properties that do not match with human bone, polymer bone implant materials have unique properties and advantages in bone implant materials. The proportion is increasing year by year. The synthesi...

Claims

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Application Information

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IPC IPC(8): C08J7/04C08L81/06
CPCC08J7/0423C08J2381/06C08J2479/02
Inventor 蹇锡高柳承德王锦艳刘程张守海宗立率
Owner DALIAN UNIV OF TECH
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