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Wheat germ globulin for blood substitute

A plasma substitute and globulin technology, applied in the field of wheat germ globulin, can solve problems such as threats to health and inability to effectively eliminate allergy cases, and achieve the effects of improving safety, reducing allergic phenomena and reducing allergic reactions.

Inactive Publication Date: 2017-05-31
河南康一元生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the research and development and clinical application of plasma substitutes have made great progress in the past half century, more and more safer and more effective plasma substitutes have been put into clinical use one after another, but some allergic cases after the use of plasma substitutes are not effective Weaning, especially for some people who are prone to allergies, seriously threatens their health

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: A wheat germ conglutinin used in plasma substitutes is obtained by extracting wheat germ conglutinins with a molecular weight range of 55±3KDa, 23±3KDa, and 16.5KDa, and then purified after modification with protease.

[0014] Described protease modification is that after using the addition amount of 3000U / g neutral protease for 30min, then using the addition amount of 1000U / g papain and 500U / g trypsin for 30min;

[0015] The wheat germ conglutinin used in the plasma substitute is used by adding 0.01% of the hydroxyethyl starch plasma substitute.

Embodiment 2

[0016] Example 2: A wheat germ conglutinin used in plasma substitutes is obtained by extracting wheat germ conglutinins with a molecular weight range of 55±3KDa, 23±3KDa, and 16.5KDa, and then purified after modification with protease.

[0017] Described protease modification is that after using the added amount of 3000U / g neutral protease for 50min, then using the added amount of 1500U / g papain and 800U / g trypsin for 60min;

[0018] The wheat germ conglutinin used in the plasma substitute is used by adding 0.05% of the hydroxyethyl starch plasma substitute.

Embodiment 3

[0019] Example 3: A wheat germ conglutinin used in plasma substitutes is obtained by extracting wheat germ conglutinins with a molecular weight range of 55±3KDa, 23±3KDa, and 16.5KDa, and then purified after modification with protease.

[0020] Described protease modification, is that after using the addition amount of 3000U / g neutral protease to treat 40min, then use the addition amount to be 1250U / g papain and 700U / g trypsin to treat 45min respectively;

[0021] The wheat germ conglutinin used in the plasma substitute is used by adding 0.025% of the hydroxyethyl starch plasma substitute.

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Abstract

The invention relates to a wheat germ globulin for a blood substitute and belongs to the technical field of medicinal and pharmaceutical substances. The scope of extracting molecular weight of the wheat germ globulin is 55+ / -3 KDa, 23+ / -3 KDa and 16.5KDa. The wheat germ globulin is acquired after the modified protease is purified. According to invention, the immune performance of the wheat germ globulin is utilized; the wheat germ globulin is added into the blood substitute, so that the use safety of the blood substitute is greatly promoted; the irritability phenomenon is greatly reduced.

Description

technical field [0001] The invention relates to a wheat germ conglutinin used in plasma substitutes, and belongs to the technical field of medical supplies. Background technique [0002] Plasma substitutes are colloidal solutions or emulsions of a class of high molecular compounds, which have a colloid osmotic pressure close to or higher than the physiological value at an appropriate concentration, maintain or even increase blood volume within a certain period of time after infusion into blood vessels, and are mainly used in large quantities Blood volume loss, shock and other emergencies caused by blood loss, plasma loss, and extensive burns are used to expand blood volume and improve microcirculation, which plays a very important role in improving the survival rate of patients. [0003] In recent years, the supply of blood sources has been tight, and homogeneous blood transfusion has the risk of spreading blood-borne diseases. Plasma substitutes are increasingly used clinic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/415C12P21/06
CPCC07K14/415C12P21/06
Inventor 董韬黄继红唐战家纪小国张战标王中林
Owner 河南康一元生物科技股份有限公司
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