A biocompatible built-in stent material

Abstract

The invention relates to a biocompatible endoprosthesis material, which comprises a matrix, a microcavity, a composition and short-peptide layers, wherein the material of the matrix is biodegradable in vivo tissues, the matrix is in a tubular shape and is provided with an inner tubular surface and an outer tubular surface, the inner surface forms a channel for a tissue fluid such as blood to pass through, and a structure for communicating the inner surface and the outer surface is arranged on the surface; the microcavity is obtained when a communicating structure is located in a cross-section direction, perpendicular to an axial direction, of a matrix body; the microcavity is located in a thickness direction of a hole; a plane of an opening of the microcavity is basically perpendicular to an inner surface and an outer surface of a tubular-shaped stent; the composition is loaded in the microcavity and can be degraded to release Fe<3+>; the short-peptide layers are located on the inner surface and the outer surface of the matrix material; short peptides can be self-assembled to form hydrogel; the hydrogel formed after the short peptides are self-assembled can be specifically favorable to climbing and covering of endothelial cells and regeneration of endodermis; a prosthesis can provide required biocompatibility, has balanced climbing and covering of an EC layer while keeping the support force of the stent, inhibits restenosis, and recovers tissues, especially the self performance of a blood vessel at the right moment.

Description

Background technique [0001] The invention belongs to the field of medical materials, and relates to a prosthetic material, in particular, a biocompatible stent material, more suitable for intravascular stent materials. [0002] The body includes various passages, such as arteries, other blood vessels, and other body lumens. Sometimes these channels become blocked or weakened. For example, a channel can be blocked by a tumor, narrowed by a plaque, or weakened by an aneurysm. When these conditions occur, the channel can be reopened or enhanced, or even replaced, using a medical endoprosthesis. An endoprosthesis is typically a tubular member that is placed in a lumen in the body. Examples of endoprostheses include stents, covered prostheses, stent grafts and vessel closure pins. [0003] Stents (stents, stents), venous filters, expandable frames and similar implantable medical devices, hereinafter collectively referred to as stents, are radially expandable internal prostheses...

AI Technical Summary

Problems solved by technology

Synthetic grafts have also been inoculated with endothelial cells, but the clinical outcome of endothelial inoculation is generally poor, most likely due to nonadhesive properties of the cells to the graft and / or loss of EC function due to ex vivo manipulation

CN105327399 provides a method for constructing artificial blood vessels, which introduces prokaryotic system expression vectors with hydrophilic and negatively charged polypeptide genes and cell adhesion-promoting polypeptide genes on the surface (Journal of DonghuaUniversity (English Edition), 2012, 29:26 -29; Bio-Medical Materials and Engineering, 2014, 24:2057–2064), which improves surface hydrophilicity and negative charge, increases endothelialization potential, and is beneficial to tissue healing and anticoagulation, but this technology is suitable for constructing artificial blood vessels, The materials used include polyester. Obviously, for the field of vascular stents that need to be degraded after vascular stenosis treatment, this material has natural non-biocompatibility and cannot provide the mechanical support properties required by vascular stents. At the same time, as mentioned above As mentioned above, if endothelial cell proliferation cannot maintain homeostasis, it will lead to the formation of vascular restenosis

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