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Bone cement and preparation method thereof

A technology of bone cement and tricalcium phosphate, applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problems of hindering bone replacement, slow degradation rate, slow degradation of calcium phosphate bone cement, etc.

Inactive Publication Date: 2017-05-31
SUZHOU AIBOMAIER NEW MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The good biocompatibility of calcium phosphate bone cement makes it an excellent material for tissue engineering bone. However, calcium phosphate bone cement degrades very slowly in the body. Three-dimensional CT shows that in the vertebral body, the degradation rate is about 2% after 12 months Left and right, the slow degradation rate seriously hinders the completion of further bone replacement, which is the biggest bottleneck restricting its large-scale clinical application

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  • Bone cement and preparation method thereof

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Effect test

Embodiment 1

[0016] A bone cement prepared from the following ingredients in parts by weight: 25 parts of hydroxyapatite, 0.8 part of α-tricalcium phosphate, 0.8 part of β-tricalcium phosphate, 7.5 parts of ε-polylysine, and 2 parts of coral powder 10 parts of high-chain cross-linked carboxymethyl starch, 1.5 parts of alanine modified polylactic acid, 1.5 parts of collagen, 5.5 parts of glucose, 3.5 parts of sodium carboxymethyl cellulose, 6 parts of sodium polyphosphate, 55 parts of water .

[0017] The preparation method of the above bone cement is as follows: (1) dissolve the glucose in water, and stir the prepared glucose solution for 40 minutes at a speed of 120r / min; (2) heat the glucose solution to 50°C, and then add sodium carboxymethyl cellulose (3) Modified hydroxyapatite, α-tricalcium phosphate, β-tricalcium phosphate, ε-polylysine, coral powder, high-chain cross-linked carboxymethyl starch, and alanine The polylactic acid, collagen, sodium polyphosphate and the curing solution...

Embodiment 2

[0019] A bone cement prepared from the following components by weight: 10 parts of hydroxyapatite, 8 parts of α-tricalcium phosphate, 8 parts of β-tricalcium phosphate, 1.8 parts of ε-polylysine, and 10 parts of coral powder 5 parts of high-chain cross-linked carboxymethyl starch, 5 parts of alanine modified polylactic acid, 0.5 parts of collagen, 1.5 parts of glucose, 0.8 parts of sodium carboxymethyl cellulose, 1.5 parts of sodium polyphosphate, 35 parts of water .

[0020] The preparation method of the above bone cement is as follows: (1) dissolve the glucose in water, and stir the prepared glucose solution for 20 minutes at a speed of 240r / min; (2) heat the glucose solution to 30°C, and then add sodium carboxymethylcellulose (3) Modified hydroxyapatite, α-tricalcium phosphate, β-tricalcium phosphate, ε-polylysine, coral powder, high-chain cross-linked carboxymethyl starch, and alanine The polylactic acid, collagen, sodium polyphosphate and the curing solution are mixed to...

Embodiment 3

[0022] A bone cement prepared from the following ingredients in parts by weight: 15 parts of hydroxyapatite, 2 parts of α-tricalcium phosphate, 2 parts of β-tricalcium phosphate, 6.5 parts of ε-polylysine, 4 parts of coral powder 9 parts of high-chain cross-linked carboxymethyl starch, 2.5 parts of alanine modified polylactic acid, 0.8 parts of collagen, 2.5 parts of glucose, 1.5 parts of sodium carboxymethyl cellulose, 3 parts of sodium polyphosphate, 40 parts of water .

[0023] The preparation method of the above bone cement is as follows: (1) dissolve the glucose in water, and stir the prepared glucose solution for 25 minutes at a speed of 200r / min; (2) heat the glucose solution to 37°C, and then add sodium carboxymethylcellulose (3) Modified hydroxyapatite, α-tricalcium phosphate, β-tricalcium phosphate, ε-polylysine, coral powder, high-chain cross-linked carboxymethyl starch, and alanine The polylactic acid, collagen, sodium polyphosphate and the curing solution are mix...

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Abstract

The invention provides a bone cement and a preparation method thereof. The preparation method comprises the following steps of (1) dissolving glucose into water, preparing a glucose solution, stirring for 20 to 40min, and setting the rotation speed to 120 to 240r / min; (2) heating the glucose solution to 30 to 50 DEG C, and adding sodium carboxymethyl cellulose, so as to obtain a curing liquid; (3) blending hydroxyapatite, alpha-tricalcium phosphate, beta-tricalcium phosphate, epsilon-polylysine, coral powder, high chain crosslinked carboxymethyl starch, aianine modified polylactic acid, collagen, sodium polyphosphate and the curing liquid, so as to obtain the bone cement. The bone cement has the advantages that the bone cement can be applied to therapy of bone regeneration, plastic and aesthetic surgery and the like; the bone cement is quickly degraded, the porosity is produced, the cells easily attach and grow, and the intercellular substance is produced, so as to improve the therapy effect.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a bone cement and a preparation method thereof. Background technique [0002] With the increasing cases of bone defects caused by various traumas, the demand for repair materials is also increasing. Autologous bone is regarded as the gold standard for repairing bone defects, but the source is limited, and the effect of allogeneic bone is also good, but there are problems of ethics and disease transmission. As a new bone repair material, calcium phosphate cement (CPCs) has the advantages of injectability, good shape, and strong osteoconductivity, but its slow absorption rate hinders its wide application; increasing the pore size ratio can significantly accelerate the absorption of CPCs , is the current research hotspot of CPCs modification. The good biocompatibility of calcium phosphate bone cement makes it an excellent material for tissue engineering bone. However, calcium phos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/24A61L27/20A61L27/18A61L27/12A61L27/56A61L27/58
CPCA61L27/3637A61L27/12A61L27/18A61L27/20A61L27/24A61L27/365A61L27/56A61L27/58A61L2430/02C08L3/08C08L77/04C08L67/04C08L85/02
Inventor 李子寅
Owner SUZHOU AIBOMAIER NEW MATERIAL CO LTD
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