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Application of PPF/PPF-DA (Poly(propylene fumarate)/Poly(propylene fumarate)-Diacrylate) light-curing material to preparation of bone adhesive tape

A light-curing material, PPF-DA technology, applied in applications, medical science, surgery, etc., can solve the problems of delaying the growth and self-healing of new bone tissue, not treating comminuted fractures, and easily damaged tissues and cells. The effect of short curing time, less heat release and easy application

Active Publication Date: 2017-05-31
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, this new type of bone adhesive has poor biodegradability (compared with the growth rate of new bone tissue at the repair site), and filling into the fracture surface will inhibit the self-healing of new bone
So far, there has not been an ideal bone adhesive that can fully meet the clinical application requirements
Moreover, even if it is an ideal bone adhesive, the idea of ​​directly coating the fracture end surface to treat comminuted fractures has two common shortcomings: first, the bone adhesive layer separates the direct contact between the fracture surfaces at the initial stage of service. Contact cuts off the physiological routes such as blood circulation, nutrient transport, and waste excretion in the bone at the initial stage of implantation, delaying the growth and self-healing of new bone tissue; second, due to the strong viscosity during the use of bone adhesive, Coated on the bare surface of the fracture and directly bonded to the bone tissue on the fracture surface, it is easy to damage the tissues and cells on the fracture surface under the action of external force during and after the operation
Therefore, the use of bone cement thinking is still not the best way to treat comminuted fractures

Method used

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  • Application of PPF/PPF-DA (Poly(propylene fumarate)/Poly(propylene fumarate)-Diacrylate) light-curing material to preparation of bone adhesive tape

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0025] Example 1: ① Weigh 0.50g component A (PPF) and 1.04g component B (PPF-DA) respectively, the double bond ratio of component A to component B is 1:2, if the viscosity of PPF and PPF-DA Larger, inconvenient to measure, first adjust the temperature to 30°C in a vacuum drying oven and heat for 5 minutes to reduce the viscosity, which is convenient to measure, and use the same Erlenmeyer flask when measuring. The weighed components A and B were dissolved in 20 mL of dry dichloromethane and mixed to obtain a mixed solution. ②Stir the mixed solution with a magnetic stirrer and continue stirring for 0.5h. After stirring, remove the magnet. The mixed solution was rotary evaporated under vacuum conditions (-0.06MPa), the temperature was set at 37°C, and the rotary evaporation continued for 1h. ③Seal the mouth of the Erlenmeyer flask containing the mixture after rotary evaporation with coarse filter paper to prevent volatilization of the mixture, put it in a vacuum drying oven, a...

example 2

[0027]Example 2: ① Weigh 1.00g of component A (PPF) and 1.73g of component B (PPF-DA) respectively, the double bond ratio of component A to component B is 3:5, if the viscosity of PPF and PPF-DA Larger, inconvenient to measure, first adjust the temperature to 30°C in a vacuum drying oven and heat for 5 minutes to reduce the viscosity, which is convenient to measure, and use the same Erlenmeyer flask when measuring. The weighed components A and B were dissolved in 20 mL of dry dichloromethane and mixed to obtain a mixed solution. ②Stir the mixed solution with a magnetic stirrer and continue stirring for 0.5h. After stirring, remove the magnet. The mixed solution was rotary evaporated under vacuum conditions (-0.06MPa), the temperature was set at 37°C, and the rotary evaporation continued for 1h. ③Seal the mouth of the Erlenmeyer flask containing the mixture after rotary evaporation with coarse filter paper to prevent volatilization of the mixture, put it in a vacuum drying ov...

example 3

[0029] Example 3: ① Weigh 1.00g of component A (PPF) and 1.39g of component B (PPF-DA) respectively, the double bond ratio of component A to component B is 3:4, if the viscosity of PPF and PPF-DA Larger, inconvenient to measure, first adjust the temperature to 30°C in a vacuum drying oven and heat for 5 minutes to reduce the viscosity, which is convenient to measure, and use the same Erlenmeyer flask when measuring. The weighed components A and B were dissolved in 20 mL of dry dichloromethane and mixed to obtain a mixed solution. ②Stir the mixed solution with a magnetic stirrer and continue stirring for 0.5h. After stirring, remove the magnet. The mixed solution was rotary evaporated under vacuum conditions (-0.06MPa), the temperature was set at 37°C, and the rotary evaporation continued for 1h. ③Seal the mouth of the Erlenmeyer flask containing the mixture after rotary evaporation with coarse filter paper to prevent volatilization of the mixture, put it in a vacuum drying o...

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Abstract

The invention discloses application of a PPF / PPF-DA (Poly(propylene fumarate) / Poly(propylene fumarate)-Diacrylate) light-curing material to preparation of a bone adhesive tape. The double-bond ratio of PPF to PPF-DA in the PPF / PPF-DA light-curing material ranges from (1 to 4) to (3 to 1); a preparation method comprises the following steps: uniformly mixing the PPF and the PPF-DA in dichloromethane; decompressing and distilling to remove a solvent for later use; adding BAPO into a mixture; carrying out ultrasonic vibration and uniformly mixing. The PPF / PPF-DA light-curing material has the characteristics of short curing time, high strength of the cured material, less heat releasing in a curing process, degradability and the like and can be applied to the field of biological medical materials; the mechanical problems of treatment of comminuted fracture in orthopaedics clinical and the like are solved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a new application of a polytrimethylene fumarate base / polytrimethylene fumarate co-diacrylate light-curing material. Background technique [0002] Fractures and fractures of bones and joints caused by trauma or pathology are common clinical orthopedic diseases. According to the statistics of American scholar Horch RA in 2004, there are more than 1 million fractures and joint ruptures in the United States every year due to various factors such as osteoporosis, strenuous exercise or accidents. my country is a country with a large population, and the problem of aging is becoming more and more serious. The number of fractures and joint ruptures that need to be treated every year far exceeds this data. At present, the main method for the clinical treatment of fractures and joint ruptures is to use biologically inert metals such as screws and bone plates or biocompatibl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00C08F299/00C08F2/48
CPCA61L24/0042A61L24/06C08F2/48C08F299/00C08L55/00
Inventor 郭大刚王亮
Owner XI AN JIAOTONG UNIV
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