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Nano-biomass-based anticancer and sustained-release gel and preparation method of nano-biomass-based anticancer and sustained-release gel

A slow-release gel and biomass technology, which can be used in anti-tumor drugs, drug combinations, drug delivery, etc., can solve the problems of cellulose gel application and cleaning difficulties, and achieve improved use value, low preparation cost, and material source. wide range of effects

Active Publication Date: 2017-05-31
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that the preparation of traditional cellulose gel materials is complicated, and the gelation process requires the help of heavy metal particles or chemical initiation, which makes the application and cleaning of cellulose gel difficult, the present invention provides a negatively charged nano A certain proportion of partially deacetylated and positively charged nano-chitin is added to the cellulose as a physical cross-linking agent, and the nano-cellulose / nano-chitin hydrogel will be generated through the physical cross-linking method of positive and negative charge mutual assembly and will fight cancer. The nano-biomass-based anti-cancer slow-release gel is prepared by loading the drug into the hydrogel. This method is simple to operate, low in cost, and has a remarkable gelling effect.

Method used

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  • Nano-biomass-based anticancer and sustained-release gel and preparation method of nano-biomass-based anticancer and sustained-release gel
  • Nano-biomass-based anticancer and sustained-release gel and preparation method of nano-biomass-based anticancer and sustained-release gel
  • Nano-biomass-based anticancer and sustained-release gel and preparation method of nano-biomass-based anticancer and sustained-release gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]Add distilled water to the 10g bleached eucalyptus pulp board, make it overflow the pulp board, then loosen in the cellulose dissociation machine, every gram of slurry adopts 0.016gTEMPO, 20mmol sodium hypochlorite, 0.16g sodium bromide, and the described oxidation temperature is At 30°C, oxidize the decomposed cellulose at pH=10.5 until the pH value remains stable. Measure the solid content of oxidized cellulose, add deionized water to prepare a cellulose dispersion with a mass concentration of 1.6%, put it in a supercell pulverizer and ultrasonically for 30 minutes to obtain a nanocellulose dispersion with a negative charge on the surface, and place it at 4 °C Stored under a sealed seal, the charge on the surface of the nanocellulose is -42.56mv, and the carboxyl content of the nanocellulose is 1.2mmol / g.

[0043] Soak 10g of discarded shrimp shells in 0.1mol / L sodium hydroxide solution for 1h to remove residual protein, then wash with deionized water to neutral, then ...

Embodiment 2

[0045] The nano-chitin dispersion prepared in Example 1 was vacuum-dried at 55° C. for 5 h, weighed 0.1 g of dried nano-chitin, and then placed in 20 ml of 0.5 mg / ml 5-fluorouracil in PBS solution, soaked for 24 h to make it Completely swell, and then vacuum-dry the swollen nano-chitin at 55°C for 5 hours again to obtain drug-loaded nano-chitin with a charge of +43.25mv and a drug loading of 341 micrograms, Figure 1a It is the electron micrograph of nano-chitin after freeze-drying, and the elastic modulus of nano-chitin dispersion is shown in figure 2 , figure 2 Among them, cellulose means nano-cellulose, Chitin means nano-chitin, Chitin-20 means nano-chitin 20% mixed gel, Chitin-40 means nano-chitin 40% mixed gel, Chitin-60 means nano-chitin 60 % mixed gel, Chitin-80 means nano-chitin 80% mixed gel.

Embodiment 3

[0047] The nanocellulose dispersion prepared in Example 1 was vacuum-dried at 55°C for 5 hours, weighed 0.1 g of dried nanocellulose, and then placed in 20 ml of 0.5 mg / ml 5-fluorouracil in PBS solution, soaked for 24 hours to make it completely Swell, and then vacuum-dry the swelled nanocellulose again at 55°C for 5h to obtain drug-loaded nanocellulose, which has a charge of -42.56mv and a drug load of 233.6 micrograms, Figure 1b It is the electron micrograph of nanocellulose after freeze-drying, and the elastic modulus of nanocellulose dispersion is shown in figure 2 .

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Abstract

The invention discloses nano-biomass-based anticancer and sustained-release gel and a preparation method of the nano-biomass-based anticancer and sustained-release gel and belongs to the field of biomass medical materials. The invention aims at providing pure biomass-based anticancer and sustained-release gel which has the advantages of simple and convenient apply, biodegradability and low preparation cost, and a preparation method of the pure biomass-based anticancer and sustained-release gel. The preparation method comprises the following steps: defibering a bleached pulp board; oxidizing to prepare nano cellulose with negative charges; carrying out impurity removal, deacetylation and protonation treatment on a chitosan raw material to prepare nano chitosan with positive charges; slowly adding the nano chitosan into the nano cellulose and stirring to crossly link to form hydrogel; after swelling the hydrogel, which is dried in vacuum, into an anticancer medicine, drying in vacuum again to prepare the nano-biomass-based anticancer and sustained-release gel. The method is simple in preparation process; the prepared anticancer and sustained-release gel is biodegradable pure biomass gel; a chemical cross-linking agent is not added, so that the nano-biomass-based anticancer and sustained-release gel is easily utilized in the field of the medical materials.

Description

technical field [0001] The invention belongs to the field of biomass medical materials, and in particular relates to a nano-biomass-based anti-cancer slow-release gel and a preparation method thereof. Background technique [0002] Gel material is a three-dimensional network structure formed by the interconnection of colloidal particles or polymers in solution under certain conditions. It is a porous material with extremely high porosity, extremely low density and high surface area. At present, it is widely used in separation, adsorption, catalysis, photoelectricity, sensors, biomedicine and other aspects. Biomass gel materials have great applications in the pharmaceutical industry and cosmetics because they incorporate their own excellent properties, such as good biocompatibility and degradability, while possessing traditional gel properties, and have become a research topic. hotspot. [0003] Cellulose is the most abundant biomass material in nature, and its good biocompa...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/513A61K47/38A61K47/36A61P35/00C08B37/08A61K9/10A61K31/337
CPCA61K9/0002A61K9/06A61K9/10A61K31/337A61K31/513A61K47/36A61K47/38C08B37/003
Inventor 田君飞徐军飞陈广学刘珊何明辉胡健
Owner SOUTH CHINA UNIV OF TECH
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