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Nasal drop and preparation method thereof

A technology of nasal drops and injections, which is applied in the field of nasal drops and its preparation, can solve problems such as poisoning, and achieve the effects of small toxic and side effects, reasonable collocation, and safe formula

Inactive Publication Date: 2017-05-17
栗明峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main ingredient of Nasal Drops currently available on the market is nazoline, which is an adrenaline-mimetic drug. This drug can cause drowsiness, vomiting and other symptoms in infants and young children. This drug is prohibited for infants and young children. At present There have been many reports of poisoning caused by the drug in infants and young children in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The invention provides a nasal drop, which is prepared from the following raw materials by weight ratio: 1-2 mL of chlorpheniramine maleate injection, containing 10-20 mg of chlorpheniramine maleate; morpholine hydrochloride Guanidine injection 1~3mL, containing morpholine guanidine hydrochloride 50~150mg; Racemic anisodamine hydrochloride injection 0.1~0.5mL, containing racemic anisodamine hydrochloride 1~5mg; Bupleurum chinensis extract 3~6mL; The preparation method of Chaihu extract is as follows: (1) Take 1000g of Chaihu, cut into 0.5-2mm pieces, soak in water, steam distillation, collect the first distillate, re-distill, collect the heavy distillate, add polysorbate 80 3g, stir to completely dissolve the oil, then add 9g of sodium chloride, after complete dissolution, filter, add water for injection to make up to 1000mL, adjust the pH value to 7.1~7.3, filter, and that’s it.

[0024] The preparation method of the nasal drops of the present invention is to mix the a...

Embodiment 2

[0026] A nasal drop, which is prepared from the following raw materials by weight: 1 mL of chlorpheniramine maleate injection, containing 10 mg of chlorpheniramine maleate; 2 mL of morpholine guanidine hydrochloride injection, containing hydrochloric acid Morpholineguanidine 100mg; Racemic Anisodamine Hydrochloride Injection 0.25mL, containing Racemic Anisodamine Hydrochloride 2.5mg; Bupleurum Extract 4mL.

[0027] The preparation method of this example is the same as that of Example 1.

Embodiment 3

[0029] A nasal drop, which is prepared from the following raw materials by weight: 1 mL of chlorpheniramine maleate injection, containing 10 mg of chlorpheniramine maleate; 3 mL of morpholine guanidine hydrochloride injection, containing hydrochloric acid Morpholineguanidine 150 mg; Racemic Anisodamine Hydrochloride Injection 0.1 mL, containing 1 mg of Racemic Anisodamine Hydrochloride; Bupleurum Radix Extract 6 mL.

[0030] The preparation method of this example is the same as that of Example 1.

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PUM

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Abstract

The invention relates to a nasal drop and a preparation method thereof. The nasal drop is prepared from the following raw material medicines in parts by weight: 1-2mL of a chlorpheniramine maleate injection which comprises 10-20mg of chlorpheniramine maleate, 1-3mL of a moroxydine hydrochloride injection which comprises 50-150mg of moroxydine hydrochloride, 0.1-0.5mL of a hydrochloric acid racanisodamine injection which comprises 1-5mg of hydrochloric acid racanisodamine, and 3-6mL of a radix bupleuri extract. The preparation method specifically comprises the following steps of: mixing the raw material medicines according to the ratio, and filling into a nasal drop container. The nasal drop is safe in medicinal formula, small in toxic and side effect, reasonable in matching of traditional Chinese medicines and western medicines, applicable to infants, free of hormone and free of drug dependency.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a nasal drop and a preparation method thereof. Background technique [0002] Rhinitis refers to inflammation of the nasal mucosa and submucosa. It is manifested as congestion or edema, and patients often have symptoms such as nasal congestion, runny nose, itchy nose, throat discomfort, and cough. The thin, liquid-like substance secreted from the nose called snot or nasal secretions helps to remove dust and bacteria to keep the lungs healthy. Usually, the snot mixed with bacteria and dust is sucked up the throat and eventually into the stomach, and because it is secreted in small quantities, it is generally unnoticed. When there is inflammation in the nose, a large amount of nasal mucus can be secreted in the nasal cavity, and it can turn yellow due to infection. When it flows through the throat, it can cause coughing. When the amount...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/233A61K31/4402A61K31/5375A61K31/46A61K9/08A61P11/02
CPCA61K36/233A61K9/0043A61K9/08A61K31/4402A61K31/46A61K31/5375A61K2236/331A61K2300/00
Inventor 栗明峰
Owner 栗明峰
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